
SEQUENCE LISTING

<110> AGENSYS, INC.
      RAITANO, Arthur B.
      CHALLITA-EID, Pia M.
      KANNER, Steven B.
      JAKOBOVITS, Aya
      GE, Wangmao
      MORRISON, Robert Kendall
      PEREZ-VILLAR, Juan

<120> NUCLEIC ACIDS AND CORRESPONDING PROTEINS
      ENTITLED 158P3D2 USEFUL IN TREATMENT AND DETECTION OF CANCER
  

<130> 511582006445

<140> To Be Assigned          
<141> Concurrently Herewith  

<150> 10/107,532          
<151> 2002-03-25  

<150> 60/283,112          
<151> 2001-04-10  

<150> 60/286,630          
<151> 2001-04-25  

<150> US02/09403          
<151> 2002-03-25  

<160> 365

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 312
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 15, 103, 167
<223> n = a, t, c, or g

<221> misc_feature   
<222> 195, 196, 197, 198
<223> n = a, t, c, or g

<221> misc_feature   
<222> 266, 267, 274
<223> n = a, t, c, or g

<400> 1
gatctcttca catgnagatt gacatctttc ctcaagatgt gcctgctcca cccccagttg 60
acatcaagcc tcggcagcca atcagctatg agctcagagt tgncatctgg aacacggagg 120
atgtggttct ggatgacgag aatccactca ccggagagat gtcgagngac atctatgtga 180
agagctgggt gaagnnnntg gagcatgaca agcaggagac agacgttcac ttcaactccc 240
tgactgtgga ggggaacttc aattgnngct ttgngctccg ctttgactac ctgcccacgg 300
agcgggagga tc                                                     312

<210> 2
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 2
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 3
<211> 328
<212> PRT
<213> Homo sapiens

<400> 3
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 4
<211> 2918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (117)...(827)

<400> 4
atcaaggccc tgggctggag gaagacatcc cagatccaga ggagctcgac tgggggtcca 60
agtactatgc gtcgctgcag gagctccagg ggcagcacaa ctttgatgaa gatgaa atg 119
                                                              Met
                                                               1
 
gat gat cct gga gat tca gat ggg gtc aac ctc att tct atg gtt ggg   167
Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly
             5                   10                  15
 
gag atc caa gac cag ggt gag gct gaa gtc aaa ggc act gtg tcc cca   215
Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro
         20                  25                  30
 
aaa aaa gca gtt gcc acc ctg aag atc tac aac agg tcc ctg gag gaa   263
Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu Glu
     35                  40                  45
 
gaa ttt aac cac ttt gaa gac tgg ctg aat gtg ttt cct ctg tac cga   311
Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg
 50                  55                  60                  65
 
ggg caa ggg ggc cag gat gga ggt gga gaa gag gaa gga tct gga cac   359
Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His
                 70                  75                  80
 
ctt gtg ggc aag ttc aag ggc tcc ttc ctc att tac cct gaa tca gag   407
Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu
             85                  90                  95
 
gca gtg ttg ttc tct gag ccc cag atc tct cgg ggg atc cca cag aac   455
Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn
        100                 105                 110
 
cgg ccc atc aag ctc ctg gtc aga gtg tat gtt gta aag gct acc aac   503
Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn
    115                 120                 125
 
ctg gct cct gca gac ccc aat ggc aaa gca gac cct tac gtg gtg gtg   551
Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val
130                 135                 140                 145
 
agc gct ggc cgg gag cgg cag gac acc aag gaa cgc tac atc ccc aag   599
Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys
                150                 155                 160
 
cag ctc aac ccc atc ttt gga gag atc ctg gag cta agc atc tct ctc   647
Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu
            165                 170                 175
 
cca gct gag acg gag ctg acg gtc gcc gta ttt gaa cat gac ctc gtg   695
Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu Val
        180                 185                 190
 
ggt tct gac gac ctc atc ggg gag acc cac att gat ctg gaa aac cga   743
Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg
    195                 200                 205
 
ttc tat agc cac cac aga gca aac tgt ggg ctg gcc tcc cag tat gaa   791
Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu
210                 215                 220                 225
 
gtg tgg gtc cag cag ggc cca cag gag cca ttc tga gtttctggcc        837
Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe  *
                230                 235
 
aaacacattc aagctcacat tcccttttgt gtctccagat cctatgattt catggaaggg 897
gaccctccca cccaccgcca ctgccaacca agacatagct cagtggtcaa gacttgggct 957
tgggagtcgg gatcctgtaa cgaatgtcac ttgaccgctt tcttttttta tgaaacagtc 1017
tcgctctgtc tcccaggttg gagtgcagtg gcacgatctc ggctgactgc aacctccacc 1077
tcctgggttc aagcgattct cctgcctcag cctccccagt agctgggatt acaggcgtgg 1137
gcccccatgt ccagctaatt tttatatttt cgctctgtct cccaggttgg agtgcagtgg 1197
cacgatctcg gctgactgca acctccacct cctgggttca agcgattctc ctgcctcagc 1257
ctccccagta gctgggatta caggcgtggg cccccatgtc cagctaattt ttatattttt 1317
agtagagaca gggtttcacc atgttgtcca ggctggtctt gaacccctga cctcaagtga 1377
tccacccacc tctgcctccc aaagtgctgg gattacaggt gtgagccacc atgccaggcc 1437
ctcttaacct cttcaagtct gttttctcat ctgcaaaaca gaggtaataa gatcagtatc 1497
ttcttaatgg aagcacctgg gctacatttt tttcattcat tgttatcata aatgaggact 1557
aacctgtctc ccgttgggag ttttgaacct agacctcatg tcttcatgac gtcatcactg 1617
ccccaggccc agctgtgtcc ctacaccagc cccagctgac gcatcttctt tttctgcctg 1677
tagagatggt tacaatgcct ggcgtgatgc attctggcct tcgcagatcc tggcggggct 1737
gtgccaacgc tgtggcctcc ctgcccctga ataccgagcc ggtgctgtca aggtgggcag 1797
caaagtcttc ctgacaccac cggagaccct gcccccaggg atctcttcac atgtggattg 1857
acatctttcc tcaagatgtg cctgctccac ccccagttga catcaagcct cggcagccaa 1917
tcagctatga gctcagagtt gtcatctgga acacggagga tgtggttctg gatgacgaga 1977
atccactcac cggagagatg tcgagtgaca tctatgtgaa gagctgggtg aaggggttgg 2037
agcatgacaa gcaggagaca gacgttcact tcaactccct gactggggag gggaacttca 2097
attggcgctt tgtgttccgc tttgactacc tgcccacgga gcgggaggtg agcgtctggc 2157
gcaggtctgg accctttgcc ctggaggagg cggagttccg gcagcctgca gtgctggtcc 2217
tgcaggatcc ctggagttgc agctaccaga catggtgcgt ggggcccggg gccccgagct 2277
ctgctctgtg cagctggccc gcaatggggc cgggccgagg tgcaatctgt ttcgctgccg 2337
ccgcctgagg ggctggtggc cggtagtgaa gctgaaggag gcagaggacg tggagcggga 2397
ggcgcaggag gctcaggctg gcaagaagaa gcgaaagcag aggaggagga agggccggcc 2457
agaagacctg gagttcacag acatgggtgg caatgtgtac atcctcacgg gcaaggtgga 2517
ggcagagttt gagctgctga ctgtggagga ggccgagaaa cggccagtgg ggaaggggcg 2577
gaagcagcca gagcctctgg agaaacccag ccgccccaaa acttccttca actggtttgt 2637
gaacccgctg aagacctttg tcttcttcat ctggcgccgg tactggcgca ccctggtgct 2697
gctgctactg gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca 2757
gatcagccag gtcatcttcc gtcccctcca caagtgactc tcgctgacct tggacactca 2817
cccagggtgc caacccttca atgcctgctc ctggaagtct ttcttaccca tgtgagctac 2877
cccagagtct agtgcttcct ctgaataaac ctatcacagc c                     2918

<210> 5
<211> 236
<212> PRT
<213> Homo sapiens

<400> 5
Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val
 1               5                  10                  15      
Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser
            20                  25                  30          
Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu
        35                  40                  45              
Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr
    50                  55                  60                  
Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly
65                  70                  75                  80  
His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser
                85                  90                  95      
Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln
            100                 105                 110         
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr
        115                 120                 125             
Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val
    130                 135                 140                 
Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro
145                 150                 155                 160 
Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser
                165                 170                 175     
Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu
            180                 185                 190         
Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn
        195                 200                 205             
Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr
    210                 215                 220                 
Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
225                 230                 235     


<210> 6
<211> 2918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (2249)...(2794)

<400> 6
atcaaggccc tgggctggag gaagacatcc cagatccaga ggagctcgac tgggggtcca 60
agtactatgc gtcgctgcag gagctccagg ggcagcacaa ctttgatgaa gatgaaatgg 120
atgatcctgg agattcagat ggggtcaacc tcatttctat ggttggggag atccaagacc 180
agggtgaggc tgaagtcaaa ggcactgtgt ccccaaaaaa agcagttgcc accctgaaga 240
tctacaacag gtccctggag gaagaattta accactttga agactggctg aatgtgtttc 300
ctctgtaccg agggcaaggg ggccaggatg gaggtggaga agaggaagga tctggacacc 360
ttgtgggcaa gttcaagggc tccttcctca tttaccctga atcagaggca gtgttgttct 420
ctgagcccca gatctctcgg gggatcccac agaaccggcc catcaagctc ctggtcagag 480
tgtatgttgt aaaggctacc aacctggctc ctgcagaccc caatggcaaa gcagaccctt 540
acgtggtggt gagcgctggc cgggagcggc aggacaccaa ggaacgctac atccccaagc 600
agctcaaccc catctttgga gagatcctgg agctaagcat ctctctccca gctgagacgg 660
agctgacggt cgccgtattt gaacatgacc tcgtgggttc tgacgacctc atcggggaga 720
cccacattga tctggaaaac cgattctata gccaccacag agcaaactgt gggctggcct 780
cccagtatga agtgtgggtc cagcagggcc cacaggagcc attctgagtt tctggccaaa 840
cacattcaag ctcacattcc cttttgtgtc tccagatcct atgatttcat ggaaggggac 900
cctcccaccc accgccactg ccaaccaaga catagctcag tggtcaagac ttgggcttgg 960
gagtcgggat cctgtaacga atgtcacttg accgctttct ttttttatga aacagtctcg 1020
ctctgtctcc caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc 1080
tgggttcaag cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc 1140
cccatgtcca gctaattttt atattttcgc tctgtctccc aggttggagt gcagtggcac 1200
gatctcggct gactgcaacc tccacctcct gggttcaagc gattctcctg cctcagcctc 1260
cccagtagct gggattacag gcgtgggccc ccatgtccag ctaattttta tatttttagt 1320
agagacaggg tttcaccatg ttgtccaggc tggtcttgaa cccctgacct caagtgatcc 1380
acccacctct gcctcccaaa gtgctgggat tacaggtgtg agccaccatg ccaggccctc 1440
ttaacctctt caagtctgtt ttctcatctg caaaacagag gtaataagat cagtatcttc 1500
ttaatggaag cacctgggct acattttttt cattcattgt tatcataaat gaggactaac 1560
ctgtctcccg ttgggagttt tgaacctaga cctcatgtct tcatgacgtc atcactgccc 1620
caggcccagc tgtgtcccta caccagcccc agctgacgca tcttcttttt ctgcctgtag 1680
agatggttac aatgcctggc gtgatgcatt ctggccttcg cagatcctgg cggggctgtg 1740
ccaacgctgt ggcctccctg cccctgaata ccgagccggt gctgtcaagg tgggcagcaa 1800
agtcttcctg acaccaccgg agaccctgcc cccagggatc tcttcacatg tggattgaca 1860
tctttcctca agatgtgcct gctccacccc cagttgacat caagcctcgg cagccaatca 1920
gctatgagct cagagttgtc atctggaaca cggaggatgt ggttctggat gacgagaatc 1980
cactcaccgg agagatgtcg agtgacatct atgtgaagag ctgggtgaag gggttggagc 2040
atgacaagca ggagacagac gttcacttca actccctgac tggggagggg aacttcaatt 2100
ggcgctttgt gttccgcttt gactacctgc ccacggagcg ggaggtgagc gtctggcgca 2160
ggtctggacc ctttgccctg gaggaggcgg agttccggca gcctgcagtg ctggtcctgc 2220
aggatccctg gagttgcagc taccagac atg gtg cgt ggg gcc cgg ggc ccc    2272
                               Met Val Arg Gly Ala Arg Gly Pro
                                1               5
 
gag ctc tgc tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc   2320
Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys
     10                  15                  20
 
aat ctg ttt cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag   2368
Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys
 25                  30                  35                  40
 
ctg aag gag gca gag gac gtg gag cgg gag gcg cag gag gct cag gct   2416
Leu Lys Glu Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala
                 45                  50                  55
 
ggc aag aag aag cga aag cag agg agg agg aag ggc cgg cca gaa gac   2464
Gly Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp
             60                  65                  70
 
ctg gag ttc aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag   2512
Leu Glu Phe Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys
         75                  80                  85
 
gtg gag gca gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg   2560
Val Glu Ala Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg
     90                  95                 100
 
cca gtg ggg aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc   2608
Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser
105                 110                 115                 120
 
cgc ccc aaa act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt   2656
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe
                125                 130                 135
 
gtc ttc ttc atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta   2704
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu
            140                 145                 150
 
ctg gtg ctg ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct   2752
Leu Val Leu Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro
        155                 160                 165
 
ggc cag atc agc cag gtc atc ttc cgt ccc ctc cac aag tga           2794
Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    170                 175                 180
 
ctctcgctga ccttggacac tcacccaggg tgccaaccct tcaatgcctg ctcctggaag 2854
tctttcttac ccatgtgagc taccccagag tctagtgctt cctctgaata aacctatcac 2914
agcc                                                              2918

<210> 7
<211> 181
<212> PRT
<213> Homo sapiens

<400> 7
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 8
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 8
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc cgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Arg Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 9
<211> 328
<212> PRT
<213> Homo sapiens

<400> 9
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Arg Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 10
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 10
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc atc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Ile Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 11
<211> 328
<212> PRT
<213> Homo sapiens

<400> 11
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Ile Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 12
<211> 1993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1385)

<400> 12
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat ttg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Leu Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat acc gca tct ctg cca atg act tcc ttg gat ccc tgg agt   1274
Trp Asp Tyr Thr Ala Ser Leu Pro Met Thr Ser Leu Asp Pro Trp Ser
            130                 135                 140
 
tgc agc tac cag aca tgg tgc gtg ggg ccc ggg gcc ccg agc tct gct   1322
Cys Ser Tyr Gln Thr Trp Cys Val Gly Pro Gly Ala Pro Ser Ser Ala
        145                 150                 155
 
ctg tgc agc tgg ccc gca atg ggg ccg ggc cga ggt gca atc tgt ttc   1370
Leu Cys Ser Trp Pro Ala Met Gly Pro Gly Arg Gly Ala Ile Cys Phe
    160                 165                 170
 
gct gcc gcc gcc tga ggggctggtg gccggtagtg aagctgaagg aggcagagga   1425
Ala Ala Ala Ala  *
175
 
cgtggagcgg gaggcgcagg aggctcaggc tggcaagaag aagcgaaagc agaggaggag 1485
gaagggccgg ccagaagacc tggagttcac agacatgggt ggcaatgtgt acatcctcac 1545
gggcaaggtg gaggcagagt ttgagctgct gactgtggag gaggccgaga aacggccagt 1605
ggggaagggg cggaagcagc cagagcctct ggagaaaccc agccgcccca aaacttcctt 1665
caactggttt gtgaacccgc tgaagacctt tgtcttcttc atctggcgcc ggtactggcg 1725
caccctggtg ctgctgctac tggtgctgct caccgtcttc ctcctcctgg tcttctacac 1785
catccctggc cagatcagcc aggtcatctt ccgtcccctc cacaagtgac tctcgctgac 1845
cttggacact cacccagggt gccaaccctt caatgcctgc tcctggaagt ctttcttacc 1905
catgtgagct accccagagt ctagtgcttc ctctgaataa acctatcaca gccacaaaaa 1965
aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                    1993

<210> 13
<211> 178
<212> PRT
<213> Homo sapiens

<400> 13
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Leu Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Thr Ala Ser Leu Pro Met Thr Ser Leu Asp Pro Trp Ser Cys Ser
    130                 135                 140                 
Tyr Gln Thr Trp Cys Val Gly Pro Gly Ala Pro Ser Ser Ala Leu Cys
145                 150                 155                 160 
Ser Trp Pro Ala Met Gly Pro Gly Arg Gly Ala Ile Cys Phe Ala Ala
                165                 170                 175     
Ala Ala
        


<210> 14
<211> 1993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1289)...(1834)

<400> 14
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcacat gtggattgac atctttcctc aagatgtgcc tgctccaccc ccagttgaca 900
tcaagcctcg gcagccaatc agctatgagc tcagagttgt catctggaac acggaggatt 960
tggttctgga tgacgagaat ccactcaccg gagagatgtc gagtgacatc tatgtgaaga 1020
gctgggtgaa ggggttggag catgacaagc aggagacaga cgttcacttc aactccctga 1080
ctggggaggg gaacttcaat tggcgctttg tgttccgctt tgactacctg cccacggagc 1140
gggaggtgag cgtctggcgc aggtctggac cctttgccct ggaggaggcg gagttccggc 1200
agcctgcagt gctggtcctg caggtctggg actataccgc atctctgcca atgacttcct 1260
tggatccctg gagttgcagc taccagac atg gtg cgt ggg gcc cgg ggc ccc    1312
                               Met Val Arg Gly Ala Arg Gly Pro
                                1               5
 
gag ctc tgc tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc   1360
Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys
     10                  15                  20
 
aat ctg ttt cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag   1408
Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys
 25                  30                  35                  40
 
ctg aag gag gca gag gac gtg gag cgg gag gcg cag gag gct cag gct   1456
Leu Lys Glu Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala
                 45                  50                  55
 
ggc aag aag aag cga aag cag agg agg agg aag ggc cgg cca gaa gac   1504
Gly Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp
             60                  65                  70
 
ctg gag ttc aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag   1552
Leu Glu Phe Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys
         75                  80                  85
 
gtg gag gca gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg   1600
Val Glu Ala Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg
     90                  95                 100
 
cca gtg ggg aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc   1648
Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser
105                 110                 115                 120
 
cgc ccc aaa act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt   1696
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe
                125                 130                 135
 
gtc ttc ttc atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta   1744
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu
            140                 145                 150
 
ctg gtg ctg ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct   1792
Leu Val Leu Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro
        155                 160                 165
 
ggc cag atc agc cag gtc atc ttc cgt ccc ctc cac aag tga           1834
Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    170                 175                 180
 
ctctcgctga ccttggacac tcacccaggg tgccaaccct tcaatgcctg ctcctggaag 1894
tctttcttac ccatgtgagc taccccagag tctagtgctt cctctgaata aacctatcac 1954
agccacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                        1993

<210> 15
<211> 181
<212> PRT
<213> Homo sapiens

<400> 15
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 16
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 16
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctgggc tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 17
<211> 328
<212> PRT
<213> Homo sapiens

<400> 17
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 18
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 18
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccca cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 19
<211> 328
<212> PRT
<213> Homo sapiens

<400> 19
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 20
<211> 1994
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (849)...(1835)

<400> 20
tttttttatg aaacagtctc gctctgtctc ccaggttgga gtgcagtggc acgatctcgg 60
ctgactgcaa cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tccccagtag 120
ctgggattac aggcgtgggc ccccatgtcc agctaatttt tatattttcg ctctgtctcc 180
caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc tgggttcaag 240
cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc cccatgtcca 300
gctaattttt atatttttag tagagacagg gtttcaccat gttgtccagg ctggtcttga 360
acccctgacc tcaagtgatc cacccacctc tgcctcccaa agtgctggga ttacaggtgt 420
gagccaccat gccaggccct cttaacctct tcaagtctgt tttctcatct gcaaaacaga 480
ggtaataaga tcagtatctt cttaatggaa gcacctggac tacatttttt tcattcattg 540
ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag acctcatgtc 600
ttcatgacgt catcactgcc ccaggcccag ctgtgtccct acaccagccc cagctgacgc 660
atcttctttt tctgcctgta gagatggtta caatgcctgg cgtgatgcat tctggccttc 720
gcagatcctg gcggggctgt gccaacgctg tggcctccct gcccctgaat accgagccgg 780
tgctgtcaag gtgggcagca aagtcttcct gacaccaccg gagaccctgc ccccagggat 840
ctcttcac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc  890
         Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
          1               5                   10
 
cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt   938
Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
 15                  20                  25                  30
 
gtc atc tgg aac acg gag gat gtg gtt ctg gac gac gag aat cca ctc   986
Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
                 35                  40                  45
 
acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg   1034
Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
             50                  55                  60
 
ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act   1082
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
         65                  70                  75
 
ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg   1130
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
     80                  85                  90
 
ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc   1178
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
 95                 100                 105                 110
 
ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc   1226
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
                115                 120                 125
 
tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag   1274
Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
            130                 135                 140
 
ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc   1322
Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
        145                 150                 155
 
tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt   1370
Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
    160                 165                 170
 
cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag   1418
Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
175                 180                 185                 190
 
gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag   1466
Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
                195                 200                 205
 
aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc   1514
Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
            210                 215                 220
 
aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca   1562
Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
        225                 230                 235
 
gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg   1610
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    240                 245                 250
 
aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa   1658
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
255                 260                 265                 270
 
act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc   1706
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                275                 280                 285
 
atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg   1754
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            290                 295                 300
 
ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc   1802
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        305                 310                 315
 
agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac 1855
Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
    320                 325
 
tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc 1915
taccccagag tctagtgctt cctctgaata aacctatcac agccacaaaa aaaaaaaaaa 1975
aaaaaaaaaa aaaaaaaaa                                              1994

<210> 21
<211> 328
<212> PRT
<213> Homo sapiens

<400> 21
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 22
<211> 7108
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(4246)

<400> 22
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag ccc cag cca ccc ctc ccc gat gtg ctg gtc tgg   2749
Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp
880                 885                 890                 895
 
atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc cgg atc cct gcc cag   2797
Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln
                900                 905                 910
 
gat gtg ctg ttc tct gtg gtt gag gag gaa cgg ggc cga gac tgt ggg   2845
Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly
            915                 920                 925
 
aag atc cag agt cta atg ctc acg gca ccc ggg gca gcc cct ggt gag   2893
Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu
        930                 935                 940
 
gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg ggc ctg ggc aag caa   2941
Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln
    945                 950                 955
 
gcc aag gcc tgc acc tct gag ctg ccc ccg gat ttg ctg ccc gag ccc   2989
Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro
960                 965                 970                 975
 
tca gcc ggg ctg ccc tcc agc cta cac cgg gac gac ttt agc tac ttc   3037
Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe
                980                 985                 990
 
caa ctc cgg gct cac ttg tac cag gcc cgg ggt gtg ttg gct gca gat   3085
Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp
             995                1000                1005
 
gac agt ggc ctc tcg gac ccc ttt gct cga gtc ctc atc tct acc cag   3133
Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln
        1010                1015                1020
 
tgt cag acc aca cgg gtc ctg gag cag acg ctg agc cct ctg tgg gat   3181
Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp
    1025                1030                1035
 
gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg gag cac   3229
Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His
1040                1045                1050                1055
 
ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac cac aat   3277
Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn
                1060                1065                1070
 
aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc cca agg   3325
Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg
            1075                1080                1085
 
gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag ttc ttc   3373
Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe
        1090                1095                1100
 
ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc gcc ttt   3421
Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe
    1105                1110                1115
 
caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca gtg ccc   3469
Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro
1120                1125                1130                1135
 
agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc cac tct   3517
Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser
                1140                1145                1150
 
gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg gag ttc   3565
Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe
            1155                1160                1165
 
cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt gtg cat   3613
Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His
        1170                1175                1180
 
ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct ggg caa   3661
Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln
    1185                1190                1195
 
ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc aat ttc   3709
Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe
1200                1205                1210                1215
 
act gag ctt gtc agg cat ctg aca gtg gac ttg ccg gag cag cct tac   3757
Thr Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr
                1220                1225                1230
 
ttg cag cct cca ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc   3805
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
            1235                1240                1245
 
cac aca gtc ctt gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc   3853
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
        1250                1255                1260
 
aca ttt cgg ggt cat gag gat cct cct gag gag gaa gga gag atg gag   3901
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
    1265                1270                1275
 
gag aca ggg gat atg atg ccc aag gga cct caa gga cag aag tcc ctg   3949
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
1280                1285                1290                1295
 
gat ccc ttc ttg gct gaa gcg ggt ata tcc aga cag ctc ctg aag cct   3997
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro
                1300                1305                1310
 
cct ctg aag aag ctc cca cta gga ggc ctc cta aat caa ggc cct ggg   4045
Pro Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly
            1315                1320                1325
 
ctg gag gaa gac atc cca gat cca gag gag ctc gac tgg ggg tcc aag   4093
Leu Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys
        1330                1335                1340
 
tac tat gcg tcg ctg cag gag ctc cag ggg cag cac aac ttt gat gaa   4141
Tyr Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu
    1345                1350                1355
 
gat gaa atg gat gat cct gga gat tca gat ggg gtc aac ctc att tct   4189
Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser
1360                1365                1370                1375
 
atg gtt ggg gag atc caa gac cag gat cta caa cag gtc cct gaa gga   4237
Met Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly
                1380                1385                1390
 
aga att taa ccactttgaa gactggctga atgtgtttcc tctgtaccga           4286
Arg Ile  *

 
gggcaagggg gccaggatgg aggtggagaa gaggaaggat ctggacacct tgtgggcaag 4346
ttcaagggct ccttcctcat ttaccctgaa tcagaggcag tgttgttctc tgagccccag 4406
atctcccggg ggatcccaca gaaccggccc atcaagctcc tggtcagagt gtatgttgta 4466
aaggctacca acctggctcc tgcagacccc aatggcaaag cagaccctta cgtggtggtg 4526
agcgctggcc gggagcggca ggacaccaag gaacgctaca tccccaagca gctcaacccc 4586
atctttggag agatcctgga gctaagcatc tctctcccag ctgagacgga gctgacggtc 4646
gccgtatttg atcatgacct cgtgggttct gacgacctca tcggggagac ccacattgat 4706
ctggaaaacc gattctatag ccaccacaga gcaaactgtg ggctggcctc ccagtatgaa 4766
gtgtgggtcc agcagggccc acaggagcca ttctgagttt ctggccaaac acattcaagc 4826
tcacattccc ttttgtgtct ccagatccta tgatttcatg gaaggggacc ctcccaccca 4886
ccgccactgc caaccaagac atagctcagt ggtcaagact tgggcttggg agtcgggatc 4946
ctgtaacgaa tgtcacttga ccgctttctt tttttatgaa acagtctcgc tctgtctccc 5006
aggttggagt gcagtggcac gatctcggct gactgcaacc tccacctcct gggttcaagc 5066
gattctcctg cctcagcctc cccagtagct gggattacag gcgtgggccc ccatgtccag 5126
ctaattttta tattttcgct ctgtctccca ggttggagtg cagtggcacg atctcggctg 5186
actgcaacct ccacctcctg ggttcaagcg attctcctgc ctcagcctcc ccagtagctg 5246
ggattacagg cgtgggcccc catgtccagc taatttttat atttttagta gagacagggt 5306
ttcaccatgt tgtccaggct ggtcttgaac ccctgacctc aagtgatcca cccacctctg 5366
cctcccaaag tgctgggatt acaggtgtga gccaccatgc caggccctct taacctcttc 5426
aagtctgttt tctcatctgc aaaacagagg taataagatc agtatcttct taatggaagc 5486
acctggacta catttttttc attcattgtt atcataaatg aggactaacc tgtctcccgt 5546
tgggagtttt gaacctagac ctcatgtctt catgacgtca tcactgcccc aggcccagct 5606
gtgtccctac accagcccca gctgacgcat cttctttttc tgcctgtaga gatggttaca 5666
atgcctggcg tgatgcattc tggccttcgc agatcctggc ggggctgtgc caacgctgtg 5726
gcctccctgc ccctgaatac cgagccggtg ctgtcaaggt gggcagcaaa gtcttcctga 5786
caccaccgga gaccctgccc ccagggatct cttcacatgt ggattgacat ctttcctcaa 5846
gatgtgcctg ctccaccccc agttgacatc aagcctcggc agccaatcag ctatgagctc 5906
agagttgtca tctggaacac ggaggatgtg gttctggatg acgagaatcc actcaccgga 5966
gagatgtcga gtgacatcta tgtgaagagg taggctgctg gccgggcggg gcaacggcgg 6026
tgcactaggg ggattgcaaa tgggtgtggg ccctcgggct gagtccagag ccccgacccc 6086
aggccctccg tggtgctgag agcggggtga ggagtgggtt ctccatgtag ctccagccct 6146
gacgctcacc caccccggcc ccagctgggt gaaggggttg gagcatgaca agcaggagac 6206
agacgttcac ttcaactccc tgactgggga ggggaacttc aattggcgct ttgtgttccg 6266
ctttgactac ctgcccacgg agcgggaggt gagcgtctgg cgcaggtctg gaccctttgc 6326
cctggaggag gcggagttcc ggcagcctgc agtgctggtc ctgcaggtct gggactatga 6386
ccgcatctct gccaatgact tccttggatc cctggagttg cagctaccag acatggtgcg 6446
tggggcccgg ggccccgagc tctgctctgt gcagctggcc cgcaatgggg ccgggccgag 6506
gtgcaatctg tttcgctgcc gccgcctgag gggctggtgg ccggtagtga agctgaagga 6566
ggcagaggac gtggagcggg aggcgcagga ggctcaggct ggcaagaaga agcgaaagca 6626
gaggaggagg aagggccggc cagaagacct ggagttcaca gacatgggtg gcaatgtgta 6686
catcctcacg ggcaaggtgg aggcagagtt tgagctgctg actgtggagg aggccgagaa 6746
acggccagtg gggaaggggc ggaagcagcc agagcctctg gagaaaccca gccgccccaa 6806
aacttccttc aactggtttg tgaacccgct gaagaccttt gtcttcttca tctggcgccg 6866
gtactggcgc accctggtgc tgctgctact ggtgctgctc accgtcttcc tcctcctggt 6926
cttctacacc atccctggcc agatcagcca ggtcatcttc cgtcccctcc acaagtgact 6986
ctcgctgacc ttggacactc acccagggtg ccaacccttc aatgcctgct cctggaagtc 7046
tttcttaccc atgtgagcta ccccagagtc tagtgcttcc tctgaataaa cctatcacag 7106
cc                                                                7108

<210> 23
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly Arg
            1380                1385                1390        
Ile
    


<210> 24
<211> 6303
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(3502)

<400> 24
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag cac aac ttt gat gaa gat gaa atg gat gat cct   2749
Phe Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met Asp Asp Pro
880                 885                 890                 895
 
gga gat tca gat ggg gtc aac ctc att tct atg gtt ggg gag atc caa   2797
Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln
                900                 905                 910
 
gac cag ggt gag gct gaa gtc aaa ggc act gtg tcc cca aaa aaa gca   2845
Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys Ala
            915                 920                 925
 
gtt gcc acc ctg aag atc tac aac agg tcc ctg aag gaa gaa ttt aac   2893
Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn
        930                 935                 940
 
cac ttt gaa gac tgg ctg aat gtg ttt cct ctg tac cga ggg caa ggg   2941
His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly
    945                 950                 955
 
ggc cag gat gga ggt gga gaa gag gaa gga tct gga cac ctt gtg ggc   2989
Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val Gly
960                 965                 970                 975
 
aag ttc aag ggc tcc ttc ctc att tac cct gaa tca gag gca gtg ttg   3037
Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu
                980                 985                 990
 
ttc tct gag ccc cag atc tcc cgg ggg atc cca cag aac cgg ccc atc   3085
Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile
             995                1000                1005
 
aag ctc ctg gtc aga gtg tat gtt gta aag cta aga aac ctt tgc aaa   3133
Lys Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys
        1010                1015                1020
 
atc caa ggt cat gaa gac ttt tgc ctg ttt tct gct gct acc aac ctg   3181
Ile Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu
    1025                1030                1035
 
gct cct gca gac ccc aat ggc aaa gca gac cct tac gtg gtg gtg agc   3229
Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser
1040                1045                1050                1055
 
gct ggc cgg gag cgg cag gac acc aag gaa cgc tac atc ccc aag cag   3277
Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln
                1060                1065                1070
 
ctc aac ccc atc ttt gga gag atc ctg gag cta agc atc tct ctc cca   3325
Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro
            1075                1080                1085
 
gct gag acg gag ctg acg gtc gcc gta ttt gat cat gac ctc gtg ggt   3373
Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly
        1090                1095                1100
 
tct gac gac ctc atc ggg gag acc cac att gat ctg gaa aac cga ttc   3421
Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe
    1105                1110                1115
 
tat agc cac cac aga gca aac tgt ggg ctg gcc tcc cag tat gaa gtg   3469
Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val
1120                1125                1130                1135
 
tgg gtc cag cag ggc cca cag gag cca ttc tga gtttctggcc aaacacattc 3522
Trp Val Gln Gln Gly Pro Gln Glu Pro Phe  *
                1140                1145
 
aagctcacat tcccttttgt gtctccagat cctatgattt catggaaggg gaccctccca 3582
cccaccgcca ctgccaacca agacatagct cagtggtcaa gacttgggct tgggagtcgg 3642
gatcctgtaa cgaatgtcac ttgaccgctt tcttttttta tgaaacagtc tcgctctgtc 3702
tcccaggttg gagtgcagtg gcacgatctc ggctgactgc aacctccacc tcctgggttc 3762
aagcgattct cctgcctcag cctccccagt agctgggatt acaggcgtgg gcccccatgt 3822
ccagctaatt tttatatttt cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 3882
gctgactgca acctccacct cctgggttca agcgattctc ctgcctcagc ctccccagta 3942
gctgggatta caggcgtggg cccccatgtc cagctaattt ttatattttt agtagagaca 4002
gggtttcacc atgttgtcca ggctggtctt gaacccctga cctcaagtga tccacccacc 4062
tctgcctccc aaagtgctgg gattacaggt gtgagccacc atgccaggcc ctcttaacct 4122
cttcaagtct gttttctcat ctgcaaaaca gaggtaataa gatcagtatc ttcttaatgg 4182
aagcacctgg actacatttt tttcattcat tgttatcata aatgaggact aacctgtctc 4242
ccgttgggag ttttgaacct agacctcatg tcttcatgac gtcatcactg ccccaggccc 4302
agctgtgtcc ctacaccagc cccagctgac gcatcttctt tttctgcctg tagagatggt 4362
tacaatgcct ggcgtgatgc attctggcct tcgcagatcc tggcggggct gtgccaacgc 4422
tgtggcctcc ctgcccctga ataccgagcc ggtgctgtca aggtgggcag caaagtcttc 4482
ctgacaccac cggagaccct gcccccaggg atctcttcac atgtggattg acatctttcc 4542
tcaagatgtg cctgctccac ccccagttga catcaagcct cggcagccaa tcagctatga 4602
gctcagagtt gtcatctgga acacggagga tgtggttctg gatgacgaga atccactcac 4662
cggagagatg tcgagtgaca tctatgtgaa gaggtaggct gctggccggg cggggcaacg 4722
gcggtgcact agggggattg caaatgggtg tgggccctcg ggctgagtcc agagccccga 4782
ccccaggccc tccgtggtgc tgagagcggg gtgaggagtg ggttctccat gtagctccag 4842
ccctgacgct cacccacccc ggccccagct gggtgaaggg gttggagcat gacaagcagg 4902
agacagacgt tcacttcaac tccctgactg gggaggggaa cttcaattgg cgctttgtgt 4962
tccgctttga ctacctgccc acggagcggg aggtgagcgt ctggcgcagg tctggaccct 5022
ttgccctgga ggaggcggag ttccggcagc ctgcagtgct ggtcctgcag gtctgggact 5082
atgaccgcat ctctgccaat gacttccttg gtattacaat gcttagcctt ccccaccctc 5142
agcccctgcc tccagccctc acctccgccc ctgcctccag ccctcacttc cgtcccccag 5202
ttccctactc tgacccaacc ttgaatcttg ggattttgga cccgaggtgt gaaacctttg 5262
ctttctggcc taattactga gttaattagg cctagaccac agtaacctcc attcccaccc 5322
agagtctctg attcaactct gatttgaccc tagcttgtca ccctgacacc gactccacag 5382
cctttggtcc ttggcactct gatcccgacc cttggccctc ttccactggg aagtagcaat 5442
gggtggaccg ctgggctgtg gtctgggtgg tctatagctg tggcctgacc gcacactgca 5502
acaactttca atgccccaat ttacaacctt ggtgtgttgc ctcctcaccc ctggcacaat 5562
gagactttga tcccatgcct aatctggtgt gctctggact tgcaggatcc ctggagttgc 5622
agctaccaga catggtgcgt ggggcccggg gccccgagct ctgctctgtg cagctggccc 5682
gcaatggggc cgggccgagg tgcaatctgt ttcgctgccg ccgcctgagg ggctggtggc 5742
cggtagtgaa gctgaaggag gcagaggacg tggagcggga ggcgcaggag gctcaggctg 5802
gcaagaagaa gcgaaagcag aggaggagga agggccggcc agaagacctg gagttcacag 5862
acatgggtgg caatgtgtac atcctcacgg gcaaggtgga ggcagagttt gagctgctga 5922
ctgtggagga ggccgagaaa cggccagtgg ggaaggggcg gaagcagcca gagcctctgg 5982
agaaacccag ccgccccaaa acttccttca actggtttgt gaacccgctg aagacctttg 6042
tcttcttcat ctggcgccgg tactggcgca ccctggtgct gctgctactg gtgctgctca 6102
ccgtcttcct cctcctggtc ttctacacca tccctggcca gatcagccag gtcatcttcc 6162
gtcccctcca caagtgactc tcgctgacct tggacactca cccagggtgc caacccttca 6222
atgcctgctc ctggaagtct ttcttaccca tgtgagctac cccagagtct agtgcttcct 6282
ctgaataaac ctatcacagc c                                           6303

<210> 25
<211> 1145
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly
                885                 890                 895     
Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp
            900                 905                 910         
Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val
        915                 920                 925             
Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His
    930                 935                 940                 
Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly
945                 950                 955                 960 
Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys
                965                 970                 975     
Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe
            980                 985                 990         
Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys
        995                 1000                1005            
Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile
    1010                1015                1020                
Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala
1025                1030                1035                1040
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
                1045                1050                1055    
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
            1060                1065                1070        
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
        1075                1080                1085            
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
    1090                1095                1100                
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
1105                1110                1115                1120
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp
                1125                1130                1135    
Val Gln Gln Gly Pro Gln Glu Pro Phe
            1140                1145


<210> 26
<211> 6161
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(6037)

<400> 26
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag ccc cag cca ccc ctc ccc gat gtg ctg gtc tgg   2749
Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp
880                 885                 890                 895
 
atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc cgg atc cct gcc cag   2797
Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln
                900                 905                 910
 
gat gtg ctg ttc tct gtg gtt gag gag gaa cgg ggc cga gac tgt ggg   2845
Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly
            915                 920                 925
 
aag atc cag agt cta atg ctc acg gca ccc ggg gca gcc cct ggt gag   2893
Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu
        930                 935                 940
 
gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg ggc ctg ggc aag caa   2941
Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln
    945                 950                 955
 
gcc aag gcc tgc acc tct gag ctg ccc ccg gat ttg ctg ccc gag ccc   2989
Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro
960                 965                 970                 975
 
tca gcc ggg ctg ccc tcc agc cta cac cgg gac gac ttt agc tac ttc   3037
Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe
                980                 985                 990
 
caa ctc cgg gct cac ttg tac cag gcc cgg ggt gtg ttg gct gca gat   3085
Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp
             995                1000                1005
 
gac agt ggc ctc tcg gac ccc ttt gct cga gtc ctc atc tct acc cag   3133
Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln
        1010                1015                1020
 
tgt cag acc aca cgg gtc ctg gag cag acg ctg agc cct ctg tgg gat   3181
Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp
    1025                1030                1035
 
gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg gag cac   3229
Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His
1040                1045                1050                1055
 
ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac cac aat   3277
Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn
                1060                1065                1070
 
aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc cca agg   3325
Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg
            1075                1080                1085
 
gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag ttc ttc   3373
Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe
        1090                1095                1100
 
ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc gcc ttt   3421
Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe
    1105                1110                1115
 
caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca gtg ccc   3469
Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro
1120                1125                1130                1135
 
agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc cac tct   3517
Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser
                1140                1145                1150
 
gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg gag ttc   3565
Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe
            1155                1160                1165
 
cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt gtg cat   3613
Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His
        1170                1175                1180
 
ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct ggg caa   3661
Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln
    1185                1190                1195
 
ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc aat ttc   3709
Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe
1200                1205                1210                1215
 
act gag ctt gtc agg cat ctg aca gtg gtc ttc aaa gac aca gct cct   3757
Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro
                1220                1225                1230
 
ctc ttc cac ccc cag gac ttg ccg gag cag cct tac ttg cag cct cca   3805
Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro
            1235                1240                1245
 
ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc cac aca gtc ctt   3853
Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu
        1250                1255                1260
 
gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc aca ttt cgg ggt   3901
Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly
    1265                1270                1275
 
cat gag gat cct cct gag gag gaa gga gag atg gag gag aca ggg gat   3949
His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp
1280                1285                1290                1295
 
atg atg ccc aag gga cct caa gga cag aag tcc ctg gat ccc ttc ttg   3997
Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu
                1300                1305                1310
 
gct gaa gcg ggt ata tcc aga cag ctc ctg aag cct cct ctg aag aag   4045
Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys
            1315                1320                1325
 
ctc cca cta gga ggc ctc cta aat caa ggc cct ggg ctg gag gaa gac   4093
Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp
        1330                1335                1340
 
atc cca gat cca gag gag ctc gac tgg ggg tcc aag tac tat gcg tcg   4141
Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser
    1345                1350                1355
 
ctg cag gag ctc cag ggg cag cac aac ttt gat gaa gat gaa atg gat   4189
Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp
1360                1365                1370                1375
 
gat cct gga gat tca gat ggg gtc aac ctc att tct atg gtt ggg gag   4237
Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu
                1380                1385                1390
 
atc caa gac cag ggt gag gct gaa gtc aaa ggc act gtg tcc cca aaa   4285
Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys
            1395                1400                1405
 
aaa gca gtt gcc acc ctg aag atc tac aac agg tcc ctg aag gaa gaa   4333
Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu
        1410                1415                1420
 
ttt aac cac ttt gaa gac tgg ctg aat gtg ttt cct ctg tac cga ggg   4381
Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly
    1425                1430                1435
 
caa ggg ggc cag gat gga ggt gga gaa gag gaa gga tct gga cac ctt   4429
Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu
1440                1445                1450                1455
 
gtg ggc aag ttc aag ggc tcc ttc ctc att tac cct gaa tca gag gca   4477
Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala
                1460                1465                1470
 
gtg ttg ttc tct gag ccc cag atc tcc cgg ggg atc cca cag aac cgg   4525
Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg
            1475                1480                1485
 
ccc atc aag ctc ctg gtc aga gtg tat gtt gta aag gct acc aac ctg   4573
Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu
        1490                1495                1500
 
gct cct gca gac ccc aat ggc aaa gca gac cct tac gtg gtg gtg agc   4621
Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser
    1505                1510                1515
 
gct ggc cgg gag cgg cag gac acc aag gaa cgc tac atc ccc aag cag   4669
Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln
1520                1525                1530                1535
 
ctc aac ccc atc ttt gga gag atc ctg gag cta agc atc tct ctc cca   4717
Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro
                1540                1545                1550
 
gct gag acg gag ctg acg gtc gcc gta ttt gat cat gac ctc gtg ggt   4765
Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly
            1555                1560                1565
 
tct gac gac ctc atc ggg gag acc cac att gat ctg gaa aac cga ttc   4813
Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe
        1570                1575                1580
 
tat agc cac cac aga gca aac tgt ggg ctg gcc tcc cag tat gaa gta   4861
Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val
    1585                1590                1595
 
gat ggt tac aat gcc tgg cgt gat gca ttc tgg cct tcg cag atc ctg   4909
Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu
1600                1605                1610                1615
 
gcg ggg ctg tgc caa cgc tgt ggc ctc cct gcc cct gaa tac cga gcc   4957
Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala
                1620                1625                1630
 
ggt gct gtc aag gtg ggc agc aaa gtc ttc ctg aca cca ccg gag acc   5005
Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr
            1635                1640                1645
 
ctg ccc cca gtg gcg agc ggg gac cct gaa gag gcc cag gca ttg ctt   5053
Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu
        1650                1655                1660
 
gtg ctg cgg cgc tgg cag gaa atg ccg ggt ttt ggg atc cag ctg gta   5101
Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val
    1665                1670                1675
 
ccc gag cat gta gaa acc agg cct ctc tac cat ccc cac agc cca ggg   5149
Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly
1680                1685                1690                1695
 
ctg cta cag gga tct ctt cac atg tgg att gac atc ttt cct caa gat   5197
Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp
                1700                1705                1710
 
gtg cct gct cca ccc cca gtt gac atc aag cct cgg cag cca atc agc   5245
Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser
            1715                1720                1725
 
tat gag ctc aga gtt gtc atc tgg aac acg gag gat gtg gtt ctg gat   5293
Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp
        1730                1735                1740
 
gac gag aat cca ctc acc gga gag atg tcg agt gac atc tat gtg aag   5341
Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys
    1745                1750                1755
 
agc tgg gtg aag ggg ttg gag cat gac aag cag gag aca gac gtt cac   5389
Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val His
1760                1765                1770                1775
 
ttc aac tcc ctg act ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc   5437
Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe
                1780                1785                1790
 
cgc ttt gac tac ctg ccc acg gag cgg gag gtg agc gtc tgg cgc agg   5485
Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg
            1795                1800                1805
 
tct gga ccc ttt gcc ctg gag gag gcg gag ttc cgg cag cct gca gtg   5533
Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val
        1810                1815                1820
 
ctg gtc ctg cag gtc tgg gac tat gac cgc atc tct gcc aat gac ttc   5581
Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe
    1825                1830                1835
 
ctt gga tcc ctg gag ttg cag cta cca gac atg gtg cgt ggg gcc cgg   5629
Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg
1840                1845                1850                1855
 
ggc ccc gag ctc tgc tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg   5677
Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro
                1860                1865                1870
 
agg tgc aat ctg ttt cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta   5725
Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val
            1875                1880                1885
 
gtg aag ctg aag gag gca gag gac ggc aag gtg gag gca gag ttt gag   5773
Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu
        1890                1895                1900
 
ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg aag ggg cgg   5821
Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg
    1905                1910                1915
 
aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa act tcc ttc   5869
Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe
1920                1925                1930                1935
 
aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc atc tgg cgc   5917
Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg
                1940                1945                1950
 
cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg ctc acc gtc   5965
Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val
            1955                1960                1965
 
ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc agc cag gtc   6013
Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val
        1970                1975                1980
 
atc ttc cgt ccc ctc cac aag tga ctctcgctga ccttggacac tcacccaggg  6067
Ile Phe Arg Pro Leu His Lys  *
    1985                1990
 
tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc taccccagag 6127
tctagtgctt cctctgaata aacctatcac agcc                             6161

<210> 27
<211> 1990
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
    1650                1655                1660                
Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro
1665                1670                1675                1680
Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu
                1685                1690                1695    
Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val
            1700                1705                1710        
Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr
        1715                1720                1725            
Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp
    1730                1735                1740                
Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser
1745                1750                1755                1760
Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe
                1765                1770                1775    
Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg
            1780                1785                1790        
Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser
        1795                1800                1805            
Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu
    1810                1815                1820                
Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu
1825                1830                1835                1840
Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly
                1845                1850                1855    
Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg
            1860                1865                1870        
Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val
        1875                1880                1885            
Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu Leu
    1890                1895                1900                
Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys
1905                1910                1915                1920
Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn
                1925                1930                1935    
Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg
            1940                1945                1950        
Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe
        1955                1960                1965            
Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile
    1970                1975                1980                
Phe Arg Pro Leu His Lys
1985                1990


<210> 28
<211> 6299
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(6175)

<400> 28
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag ccc cag cca ccc ctc ccc gat gtg ctg gtc tgg   2749
Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp
880                 885                 890                 895
 
atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc cgg atc cct gcc cag   2797
Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln
                900                 905                 910
 
gat gtg ctg ttc tct gtg gtt gag gag gaa cgg ggc cga gac tgt ggg   2845
Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly
            915                 920                 925
 
aag atc cag agt cta atg ctc acg gca ccc ggg gca gcc cct ggt gag   2893
Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu
        930                 935                 940
 
gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg ggc ctg ggc aag caa   2941
Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln
    945                 950                 955
 
gcc aag gcc tgc acc tct gag ctg ccc ccg gat ttg ctg ccc gag ccc   2989
Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro
960                 965                 970                 975
 
tca gcc ggg ctg ccc tcc agc cta cac cgg gac gac ttt agc tac ttc   3037
Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe
                980                 985                 990
 
caa ctc cgg gct cac ttg tac cag gcc cgg ggt gtg ttg gct gca gat   3085
Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp
             995                1000                1005
 
gac agt ggc ctc tcg gac ccc ttt gct cga gtc ctc atc tct acc cag   3133
Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln
        1010                1015                1020
 
tgt cag acc aca cgg gtc ctg gag cag acg ctg agc cct ctg tgg gat   3181
Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp
    1025                1030                1035
 
gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg gag cac   3229
Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His
1040                1045                1050                1055
 
ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac cac aat   3277
Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn
                1060                1065                1070
 
aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc cca agg   3325
Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg
            1075                1080                1085
 
gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag ttc ttc   3373
Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe
        1090                1095                1100
 
ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc gcc ttt   3421
Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe
    1105                1110                1115
 
caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca gtg ccc   3469
Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro
1120                1125                1130                1135
 
agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc cac tct   3517
Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser
                1140                1145                1150
 
gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg gag ttc   3565
Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe
            1155                1160                1165
 
cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt gtg cat   3613
Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His
        1170                1175                1180
 
ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct ggg caa   3661
Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln
    1185                1190                1195
 
ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc aat ttc   3709
Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe
1200                1205                1210                1215
 
act gag ctt gtc agg cat ctg aca gtg gtc ttc aaa gac aca gct cct   3757
Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro
                1220                1225                1230
 
ctc ttc cac ccc cag gac ttg ccg gag cag cct tac ttg cag cct cca   3805
Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro
            1235                1240                1245
 
ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc cac aca gtc ctt   3853
Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu
        1250                1255                1260
 
gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc aca ttt cgg ggt   3901
Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly
    1265                1270                1275
 
cat gag gat cct cct gag gag gaa gga gag atg gag gag aca ggg gat   3949
His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp
1280                1285                1290                1295
 
atg atg ccc aag gga cct caa gga cag aag tcc ctg gat ccc ttc ttg   3997
Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu
                1300                1305                1310
 
gct gaa gcg ggt ata tcc aga cag ctc ctg aag cct cct ctg aag aag   4045
Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys
            1315                1320                1325
 
ctc cca cta gga ggc ctc cta aat caa ggc cct ggg ctg gag gaa gac   4093
Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp
        1330                1335                1340
 
atc cca gat cca gag gag ctc gac tgg ggg tcc aag tac tat gcg tcg   4141
Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser
    1345                1350                1355
 
ctg cag gag ctc cag ggg cag cac aac ttt gat gaa gat gaa atg gat   4189
Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp
1360                1365                1370                1375
 
gat cct gga gat tca gat ggg gtc aac ctc att tct atg gtt ggg gag   4237
Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu
                1380                1385                1390
 
atc caa gac cag ggt gag gct gaa gtc aaa ggc act gtg tcc cca aaa   4285
Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys
            1395                1400                1405
 
aaa gca gtt gcc acc ctg aag atc tac aac agg tcc ctg aag gaa gaa   4333
Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu
        1410                1415                1420
 
ttt aac cac ttt gaa gac tgg ctg aat gtg ttt cct ctg tac cga ggg   4381
Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly
    1425                1430                1435
 
caa ggg ggc cag gat gga ggt gga gaa gag gaa gga tct gga cac ctt   4429
Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu
1440                1445                1450                1455
 
gtg ggc aag ttc aag ggc tcc ttc ctc att tac cct gaa tca gag gca   4477
Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala
                1460                1465                1470
 
gtg ttg ttc tct gag ccc cag atc tcc cgg ggg atc cca cag aac cgg   4525
Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg
            1475                1480                1485
 
ccc atc aag ctc ctg gtc aga gtg tat gtt gta aag gct acc aac ctg   4573
Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu
        1490                1495                1500
 
gct cct gca gac ccc aat ggc aaa gca gac cct tac gtg gtg gtg agc   4621
Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser
    1505                1510                1515
 
gct ggc cgg gag cgg cag gac acc aag gaa cgc tac atc ccc aag cag   4669
Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln
1520                1525                1530                1535
 
ctc aac ccc atc ttt gga gag atc ctg gag cta agc atc tct ctc cca   4717
Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro
                1540                1545                1550
 
gct gag acg gag ctg acg gtc gcc gta ttt gat cat gac ctc gtg ggt   4765
Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly
            1555                1560                1565
 
tct gac gac ctc atc ggg gag acc cac att gat ctg gaa aac cga ttc   4813
Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe
        1570                1575                1580
 
tat agc cac cac aga gca aac tgt ggg ctg gcc tcc cag tat gaa gta   4861
Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val
    1585                1590                1595
 
gat ggt tac aat gcc tgg cgt gat gca ttc tgg cct tcg cag atc ctg   4909
Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu
1600                1605                1610                1615
 
gcg ggg ctg tgc caa cgc tgt ggc ctc cct gcc cct gaa tac cga gcc   4957
Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala
                1620                1625                1630
 
ggt gct gtc aag gtg ggc agc aaa gtc ttc ctg aca cca ccg gag acc   5005
Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr
            1635                1640                1645
 
ctg ccc cca ggc agc agc agc ccc aca gtg gcg agc ggg gac cct gaa   5053
Leu Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu
        1650                1655                1660
 
gag gcc cag gca ttg ctt gtg ctg cgg cgc tgg cag gaa atg ccg ggt   5101
Glu Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly
    1665                1670                1675
 
ttt ggg atc cag ctg gta ccc gag cat gta gaa acc agg cct ctc tac   5149
Phe Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr
1680                1685                1690                1695
 
cat ccc cac agc cca ggg ctg cta cag gga tct ctt cac atg tgg att   5197
His Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile
                1700                1705                1710
 
gac atc ttt cct caa gat gtg cct gct cca ccc cca gtt gac atc aag   5245
Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys
            1715                1720                1725
 
cct cgg cag cca atc agc tat gag ctc aga gtt gtc atc tgg aac acg   5293
Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr
        1730                1735                1740
 
gag gat gtg gtt ctg gat gac gag aat cca ctc acc gga gag atg tcg   5341
Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser
    1745                1750                1755
 
agt gac atc tat gtg aag agc tgg gtg aag ggg ttg gag cat gac aag   5389
Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys
1760                1765                1770                1775
 
cag gag aca gac gtt cac ttc aac tcc ctg act ggg gag ggg aac ttc   5437
Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe
                1780                1785                1790
 
aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg ccc acg gag cgg gag   5485
Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu
            1795                1800                1805
 
gtg agc gtc tgg cgc agg tct gga ccc ttt gcc ctg gag gag gcg gag   5533
Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu
        1810                1815                1820
 
ttc cgg cag cct gca gtg ctg gtc ctg cag gtc tgg gac tat gac cgc   5581
Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg
    1825                1830                1835
 
atc tct gcc aat gac ttc ctt gga tcc ctg gag ttg cag cta cca gac   5629
Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp
1840                1845                1850                1855
 
atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc tct gtg cag ctg gcc   5677
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
                1860                1865                1870
 
cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt cgc tgc cgc cgc ctg   5725
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            1875                1880                1885
 
agg ggc tgg tgg ccg gta gtg aag ctg aag gag gca gag gac gtg gag   5773
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        1890                1895                1900
 
cgg gag gcg cag gag gct cag gct ggc aag aag aag cga aag cag agg   5821
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    1905                1910                1915
 
agg agg aag ggc cgg cca gaa gac ctg gag ttc aca gac atg ggt ggc   5869
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
1920                1925                1930                1935
 
aat gtg tac atc ctc acg ggc aag gtg gag gca gag ttt gag ctg ctg   5917
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                1940                1945                1950
 
act gtg gag gag gcc gag aaa cgg cca gtg ggg aag ggg cgg aag cag   5965
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            1955                1960                1965
 
cca gag cct ctg gag aaa ccc agc cgc ccc aaa act tcc ttc aac tgg   6013
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        1970                1975                1980
 
ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc atc tgg cgc cgg tac   6061
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    1985                1990                1995
 
tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg ctc acc gtc ttc ctc   6109
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
2000                2005                2010                2015
 
ctc ctg gtc ttc tac acc atc cct ggc cag atc agc cag gtc atc ttc   6157
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                2020                2025                2030
 
cgt ccc ctc cac aag tga ctctcgctga ccttggacac tcacccaggg          6205
Arg Pro Leu His Lys  *
            2035
 
tgccaaccct tcaatgcctg ctcctggaag tctttcttac ccatgtgagc taccccagag 6265
tctagtgctt cctctgaata aacctatcac agcc                             6299

<210> 29
<211> 2036
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu Glu
    1650                1655                1660                
Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe
1665                1670                1675                1680
Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His
                1685                1690                1695    
Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp
            1700                1705                1710        
Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro
        1715                1720                1725            
Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu
    1730                1735                1740                
Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser
1745                1750                1755                1760
Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln
                1765                1770                1775    
Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn
            1780                1785                1790        
Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val
        1795                1800                1805            
Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
    1810                1815                1820                
Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile
1825                1830                1835                1840
Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met
                1845                1850                1855    
Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg
            1860                1865                1870        
Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg
        1875                1880                1885            
Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg
    1890                1895                1900                
Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg
1905                1910                1915                1920
Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn
                1925                1930                1935    
Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr
            1940                1945                1950        
Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro
        1955                1960                1965            
Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe
    1970                1975                1980                
Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp
1985                1990                1995                2000
Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu
                2005                2010                2015    
Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg
            2020                2025                2030        
Pro Leu His Lys
        2035    


<210> 30
<211> 6855
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (2932)...(4764)

<400> 30
agaagaaagc tggtaggggc tgggagaggg taccacaggg gagtatgatc tacttggggg 60
ccagagaagg ttccctgagg aaatagtacc tgaacttaga cttgaaggat aacagatgtt 120
aactgggagg agagaatgtt ccaggcagag gaaaaggcat atgcaaaagt ccagcgcctt 180
gaaggagcac agctggggtg cctggagtga gatggagctg gaaagatcca ggtggagctt 240
gacctgaagt accagccccc agagggcgct actggagcct ggtcagagga ggactttggg 300
gcacccatcc aggacagctt cgagttaatc atccccaatg tgggcttcca ggaactggag 360
cctggggagg cccagctgga gcggcgggca gtggctctag gccgcaggct agctcgaagt 420
ctaggccagc aggacgatga agagaatgag ctggagcttg agctggagca ggacctggat 480
gatgagcctg acgtggaact ttctggtgtt atgttcagcc ccctcaagag ccgcgccagg 540
gccctggccc atggggatcc cttccaggtg tccagagctc aagacttcca ggtgggagtc 600
actgtgctgg aagcccagaa actggtggga gtcaacatta acccctatgt ggccgtgcaa 660
gtgggggggc agcgccgtgt gaccgccaca cagcgtggga ccagttgccc cttctacaat 720
gagtacttct tgttcgaatt tcatgacacg cggcttcgtc tccaagactt gctgctggag 780
atcacggtga gtggggtagg ggtgaccagt gtccttcaga gaagggggga tgagaaagct 840
gcaggactaa caccaccttc ccccaaggct ttccattcgc agaccctccc ctttatggcc 900
acccggatag gcaccttcag gatggacctg ggcatcatct tggaccagcc aggtatggaa 960
tcgtcccctt attgagactc tgcacggaca agggccctag agattgaccc tgcagtgact 1020
ccgcatggac ccctatacac tcacttcgga gagggccatc tctggcggag gctgaactct 1080
tggcacttcc gcccctccct gctgagccag agaagccctg gccattgtcc gtcactccga 1140
tagcctcacg gccaccctgt gcgtcccgcc ggtcgcccct tacccctggc tcgccccttc 1200
gcccttagat ggccagttct accaaagatg ggttccgctg catgatcccc gagacacccg 1260
cgccgggacc aagggtttca ttaaggtcac cttgtccgtg agggcgcgcg gggacctgcc 1320
ccctccaatg ctacccccgg ccccagggca ctgttcggac atcgagaagt gagccggggt 1380
gaggtgggga ggaggacatg gatccggggg tggccgtggg gcgcggataa ggggaggggc 1440
cgagatccca gtttctcccc ccccgctcgg tgccccctcc cctaggaacc tgctcctgcc 1500
gcgcggggtg cccgccgaga ggccatgggc gcggctccgc gtgcgcctgt accgcgccga 1560
ggggcttccc gcgctgcgcc tggggctgct gggcagcctg gtccgcgccc tgcacgacca 1620
gcgcgtcctg gtggagccct atgtgcgggt gtctttcctg gggcaggagg gcgagacgtc 1680
ggtgagcgcc gaggcggcgg cgcccgaatg gaacgagcag ctgagcttcg tggagctctt 1740
cccgccgctg acgcgcagcc tccgcctgca gctgcgggac gacgcgcccc tggtcgacgc 1800
ggcactcgct acgcacgtgc cggacctgag gcggatctcc catccgggcc gcgcggcggg 1860
gtttaaccct accttcggcc cggcctgggt gcccctctat ggctcgcccc ccggcgcggg 1920
gctccgggat agtcttcaag gtctcaacga aggcgttggc caaggcattt ggttccgcgg 1980
ccgccttctg ctggctgtgt ccatgcaggt gttggaaggg agagctgaac ctgagcctcc 2040
ccaggcccag caggggtcca cgttgtcccg gctcacccga aagaagaaaa agaaagccag 2100
aagggatcag accccaaagg cggttccgca gcacttggac gccagccccg gtgccgaggg 2160
gcctgagatc ccccgtgcca tggaggtgga ggtggaggag ctgctgccgc tgccagagaa 2220
tgtcctggcg ccctgtgaag atttcctgct tttcggtgtg ctcttcgagg ccaccatgat 2280
cgaccccacc gtggcctccc agcccatcag cttcgagatc tccattggtg tgtggcctag 2340
ccgaacccct gagtgccatt tcagacctta gaaccctgga aggggtgttg actttcagtc 2400
gcgcaggccg tctggaggag caattgggcc gagggtccag ggctggggag ggaactgagg 2460
gtgcagccgt ggaggctcag cctctgctgg gagccaggcc agaggaggag aaagaggagg 2520
aagaactggg gacccatgct cagcggcctg agcccatgga cggcagtggg ccatacttct 2580
gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg gagttgctgg gaggaccaca 2640
cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc cgagaggctg gaccaggggc 2700
tgcaggaggt tgagagactg cagcgcaagc cggggcctgg cgcctgtgca cagctcaagc 2760
aggcactgga agtactggtg gctgggagca gacagttttg ccacggtgcc gagcgcagga 2820
cgatgacccg gcccaatgcc ctggatcgat gccgagggaa actcctggtg cacagcctga 2880
accttttggc taagcaagga ctgcgacttc tacgcggcct gagacggcgc a atg tgc  2937
                                                         Met Cys
                                                          1
 
aaa aga agg tgg cac tgg cca aga agc tcc tgg caa aac tgc gct ttc   2985
Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys Ala Phe
         5                   10                  15
 
tgg ctg agg agg cac ccg ggg cag ccc ctg gtg agg tct gtg cca agc   3033
Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val Pro Ser
     20                  25                  30
 
tgg agc tct tcc tgc ggc tgg gcc tgg gca agc aag cca agg cct gca   3081
Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg Pro Ala
 35                  40                  45                  50
 
cct ctg agc tgc ccc cgg att tgc tgc ccg agc cct cag ccg ggc tgc   3129
Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro Gly Cys
                 55                  60                  65
 
cct cca gcc tac acc ggg acg gtc ctg gag cag acg ctg agc cct ctg   3177
Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser Pro Leu
             70                  75                  80
 
tgg gat gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg   3225
Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg
         85                  90                  95
 
gag cac ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac   3273
Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp
    100                 105                 110
 
cac aat aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc   3321
His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala
115                 120                 125                 130
 
cca agg gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag   3369
Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln
                135                 140                 145
 
ttc ttc ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc   3417
Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala
            150                 155                 160
 
gcc ttt caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca   3465
Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser
        165                 170                 175
 
gtg ccc agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc   3513
Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro
    180                 185                 190
 
cac tct gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg   3561
His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg
195                 200                 205                 210
 
gag ttc cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt   3609
Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg
                215                 220                 225
 
gtg cat ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct   3657
Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala
            230                 235                 240
 
ggg caa ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc   3705
Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro
        245                 250                 255
 
aat ttc act gag ctt gtc agg cat ctg aca gtg gtc ttc aaa gac aca   3753
Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr
    260                 265                 270
 
gct cct ctc ttc cac ccc cag gac ttg ccg gag cag cct tac ttg cag   3801
Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln
275                 280                 285                 290
 
cct cca ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc cac aca   3849
Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr
                295                 300                 305
 
gtc ctt gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc aca ttt   3897
Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe
            310                 315                 320
 
cgg ggt cat gag gat cct cct gag gag gaa gga gag atg gag gag aca   3945
Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr
        325                 330                 335
 
ggg gat atg atg ccc aag gga cct caa gga cag aag tcc ctg gat ccc   3993
Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro
    340                 345                 350
 
ttc ttg gct gaa gcg ggt ata tcc aga cag ctc ctg aag cac aac ttt   4041
Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His Asn Phe
355                 360                 365                 370
 
gat gaa gat gaa atg gat gat cct gga gat tca gat ggg gtc aac ctc   4089
Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu
                375                 380                 385
 
att tct atg gtt ggg gag atc caa gac cag ggt gag gct gaa gtc aaa   4137
Ile Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys
            390                 395                 400
 
ggc act gtg tcc cca aaa aaa gca gtt gcc acc ctg aag atc tac aac   4185
Gly Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn
        405                 410                 415
 
agg tcc ctg aag gaa gaa ttt aac cac ttt gaa gac tgg ctg aat gtg   4233
Arg Ser Leu Lys Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val
    420                 425                 430
 
ttt cct ctg tac cga ggg caa ggg ggc cag gat gga ggt gga gaa gag   4281
Phe Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu
435                 440                 445                 450
 
gaa gga tct gga cac ctt gtg ggc aag ttc aag ggc tcc ttc ctc att   4329
Glu Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile
                455                 460                 465
 
tac cct gaa tca gag gca gtg ttg ttc tct gag ccc cag atc tcc cgg   4377
Tyr Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg
            470                 475                 480
 
ggg atc cca cag aac cgg ccc atc aag ctc ctg gtc aga gtg tat gtt   4425
Gly Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val
        485                 490                 495
 
gta aag gct acc aac ctg gct cct gca gac ccc aat ggc aaa gca gac   4473
Val Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp
    500                 505                 510
 
cct tac gtg gtg gtg agc gct ggc cgg gag cgg cag gac acc aag gaa   4521
Pro Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu
515                 520                 525                 530
 
cgc tac atc ccc aag cag ctc aac ccc atc ttt gga gag atc ctg gag   4569
Arg Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu
                535                 540                 545
 
cta agc atc tct ctc cca gct gag acg gag ctg acg gtc gcc gta ttt   4617
Leu Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe
            550                 555                 560
 
gat cat gac ctc gtg ggt tct gac gac ctc atc ggg gag acc cac att   4665
Asp His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile
        565                 570                 575
 
gat ctg gaa aac cga ttc tat agc cac cac aga gca aac tgt ggg ctg   4713
Asp Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu
    580                 585                 590
 
gcc tcc cag tat gaa gtg tgg gtc cag cag ggc cca cag gag cca ttc   4761
Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
595                 600                 605                 610
 
tga gtttctggcc aaacacattc aagctcacat tcccttttgt gtctccagat        4814
 *

 
cctatgattt catggaaggg gaccctccca cccaccgcca ctgccaacca agacatagct 4874
cagtggtcaa gacttgggct tgggagtcgg gatcctgtaa cgaatgtcac ttgaccgctt 4934
tcttttttta tgaaacagtc tcgctctgtc tcccaggttg gagtgcagtg gcacgatctc 4994
ggctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 5054
agctgggatt acaggcgtgg gcccccatgt ccagctaatt tttatatttt cgctctgtct 5114
cccaggttgg agtgcagtgg cacgatctcg gctgactgca acctccacct cctgggttca 5174
agcgattctc ctgcctcagc ctccccagta gctgggatta caggcgtggg cccccatgtc 5234
cagctaattt ttatattttt agtagagaca gggtttcacc atgttgtcca ggctggtctt 5294
gaacccctga cctcaagtga tccacccacc tctgcctccc aaagtgctgg gattacaggt 5354
gtgagccacc atgccaggcc ctcttaacct cttcaagtct gttttctcat ctgcaaaaca 5414
gaggtaataa gatcagtatc ttcttaatgg aagcacctgg actacatttt tttcattcat 5474
tgttatcata aatgaggact aacctgtctc ccgttgggag ttttgaacct agacctcatg 5534
tcttcatgac gtcatcactg ccccaggccc agctgtgtcc ctacaccagc cccagctgac 5594
gcatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc attctggcct 5654
tcgcagatcc tggcggggct gtgccaacgc tgtggcctcc ctgcccctga ataccgagcc 5714
ggtgctgtca aggtgggcag caaagtcttc ctgacaccac cggagaccct gcccccaggg 5774
atctcttcac atgtggattg acatctttcc tcaagatgtg cctgctccac ccccagttga 5834
catcaagcct cggcagccaa tcagctatga gctcagagtt gtcatctgga acacggagga 5894
tgtggttctg gatgacgaga atccactcac cggagagatg tcgagtgaca tctatgtgaa 5954
gagctgggtg aaggggttgg agcatgacaa gcaggagaca gacgttcact tcaactccct 6014
gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc tgcccacgga 6074
gcgggaggtg agcgtctggc gcaggtctgg accctttgcc ctggaggagg cggagttccg 6134
gcagcctgca gtgctggtcc tgcaggatcc ctggagttgc agctaccaga catggtgcgt 6194
ggggcccggg gccccgagct ctgctctgtg cagctggccc gcaatggggc cgggccgagg 6254
tgcaatctgt ttcgctgccg ccgcctgagg ggctggtggc cggtagtgaa gctgaaggag 6314
gcagaggacg tggagcggga ggcgcaggag gctcaggctg gcaagaagaa gcgaaagcag 6374
aggaggagga agggccggcc agaagacctg gagttcacag acatgggtgg caatgtgtac 6434
atcctcacgg gcaaggtgga ggcagagttt gagctgctga ctgtggagga ggccgagaaa 6494
cggccagtgg ggaaggggcg gaagcagcca gagcctctgg agaaacccag ccgccccaaa 6554
acttccttca actggtttgt gaacccgctg aagacctttg tcttcttcat ctggcgccgg 6614
tactggcgca ccctggtgct gctgctactg gtgctgctca ccgtcttcct cctcctggtc 6674
ttctacacca tccctggcca gatcagccag gtcatcttcc gtcccctcca caagtgactc 6734
tcgctgacct tggacactca cccagggtgc caacccttca atgcctgctc ctggaagtct 6794
ttcttaccca tgtgagctac cccagagtct agtgcttcct ctgaataaac ctatcacagc 6854
c                                                                 6855

<210> 31
<211> 610
<212> PRT
<213> Homo sapiens

<400> 31
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly
                85                  90                  95      
Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val
            100                 105                 110         
Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu
        115                 120                 125             
Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu
    130                 135                 140                 
Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu
145                 150                 155                 160 
Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu
                165                 170                 175     
Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val
            180                 185                 190         
Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val
        195                 200                 205             
Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu
    210                 215                 220                 
Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu
225                 230                 235                 240 
Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu
                245                 250                 255     
Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys
            260                 265                 270         
Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr
        275                 280                 285             
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
    290                 295                 300                 
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
305                 310                 315                 320 
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
                325                 330                 335     
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
            340                 345                 350         
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His
        355                 360                 365             
Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val
    370                 375                 380                 
Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu
385                 390                 395                 400 
Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile
                405                 410                 415     
Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His Phe Glu Asp Trp Leu
            420                 425                 430         
Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly
        435                 440                 445             
Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe
    450                 455                 460                 
Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile
465                 470                 475                 480 
Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val
                485                 490                 495     
Tyr Val Val Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys
            500                 505                 510         
Ala Asp Pro Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr
        515                 520                 525             
Lys Glu Arg Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile
    530                 535                 540                 
Leu Glu Leu Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala
545                 550                 555                 560 
Val Phe Asp His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr
                565                 570                 575     
His Ile Asp Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys
            580                 585                 590         
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
        595                 600                 605             
Pro Phe
    610 


<210> 32
<211> 6125
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(6001)

<400> 32
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag ccc cag cca ccc ctc ccc gat gtg ctg gtc tgg   2749
Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp
880                 885                 890                 895
 
atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc cgg atc cct gcc cag   2797
Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln
                900                 905                 910
 
gat gtg ctg ttc tct gtg gtt gag gag gaa cgg ggc cga gac tgt ggg   2845
Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly
            915                 920                 925
 
aag atc cag agt cta atg ctc acg gca ccc ggg gca gcc cct ggt gag   2893
Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu
        930                 935                 940
 
gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg ggc ctg ggc aag caa   2941
Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln
    945                 950                 955
 
gcc aag gcc tgc acc tct gag ctg ccc ccg gat ttg ctg ccc gag ccc   2989
Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro
960                 965                 970                 975
 
tca gcc ggg ctg ccc tcc agc cta cac cgg gac gac ttt agc tac ttc   3037
Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe
                980                 985                 990
 
caa ctc cgg gct cac ttg tac cag gcc cgg ggt gtg ttg gct gca gat   3085
Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp
             995                1000                1005
 
gac agt ggc ctc tcg gac ccc ttt gct cga gtc ctc atc tct acc cag   3133
Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln
        1010                1015                1020
 
tgt cag acc aca cgg gtc ctg gag cag acg ctg agc cct ctg tgg gat   3181
Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp
    1025                1030                1035
 
gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg gag cac   3229
Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His
1040                1045                1050                1055
 
ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac cac aat   3277
Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn
                1060                1065                1070
 
aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc cca agg   3325
Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg
            1075                1080                1085
 
gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag ttc ttc   3373
Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe
        1090                1095                1100
 
ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc gcc ttt   3421
Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe
    1105                1110                1115
 
caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca gtg ccc   3469
Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro
1120                1125                1130                1135
 
agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc cac tct   3517
Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser
                1140                1145                1150
 
gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg gag ttc   3565
Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe
            1155                1160                1165
 
cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt gtg cat   3613
Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His
        1170                1175                1180
 
ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct ggg caa   3661
Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln
    1185                1190                1195
 
ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc aat ttc   3709
Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe
1200                1205                1210                1215
 
act gag ctt gtc agg cat ctg aca gtg gac ttg ccg gag cag cct tac   3757
Thr Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr
                1220                1225                1230
 
ttg cag cct cca ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc   3805
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
            1235                1240                1245
 
cac aca gtc ctt gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc   3853
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
        1250                1255                1260
 
aca ttt cgg ggt cat gag gat cct cct gag gag gaa gga gag atg gag   3901
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
    1265                1270                1275
 
gag aca ggg gat atg atg ccc aag gga cct caa gga cag aag tcc ctg   3949
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
1280                1285                1290                1295
 
gat ccc ttc ttg gct gaa gcg ggt ata tcc aga cag ctc ctg aag cct   3997
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro
                1300                1305                1310
 
cct ctg aag aag ctc cca cta gga ggc ctc cta aat caa ggc cct ggg   4045
Pro Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly
            1315                1320                1325
 
ctg gag gaa gac atc cca gat cca gag gag ctc gac tgg ggg tcc aag   4093
Leu Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys
        1330                1335                1340
 
tac tat gcg tcg ctg cag gag ctc cag ggg cag cac aac ttt gat gaa   4141
Tyr Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu
    1345                1350                1355
 
gat gaa atg gat gat cct gga gat tca gat ggg gtc aac ctc att tct   4189
Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser
1360                1365                1370                1375
 
atg gtt ggg gag atc caa gac cag ggt gag gct gaa gtc aaa ggc act   4237
Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr
                1380                1385                1390
 
gtg tcc cca aaa aaa gca gtt gcc acc ctg aag atc tac aac agg tcc   4285
Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser
            1395                1400                1405
 
ctg gag gaa gaa ttt aac cac ttt gaa gac tgg ctg aat gtg ttt cct   4333
Leu Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro
        1410                1415                1420
 
ctg tac cga ggg caa ggg ggc cag gat gga ggt gga gaa gag gaa gga   4381
Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly
    1425                1430                1435
 
tct gga cac ctt gtg ggc aag ttc aag ggc tcc ttc ctc att tac cct   4429
Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro
1440                1445                1450                1455
 
gaa tca gag gca gtg ttg ttc tct gag ccc cag atc tcc cgg ggg atc   4477
Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile
                1460                1465                1470
 
cca cag aac cgg ccc atc aag ctc ctg gtc aga gtg tat gtt gta aag   4525
Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys
            1475                1480                1485
 
gct acc aac ctg gct cct gca gac ccc aat ggc aaa gca gac cct tac   4573
Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr
        1490                1495                1500
 
gtg gtg gtg agc gct ggc cgg gag cgg cag gac acc aag gaa cgc tac   4621
Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr
    1505                1510                1515
 
atc ccc aag cag ctc aac ccc atc ttt gga gag atc ctg gag cta agc   4669
Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser
1520                1525                1530                1535
 
atc tct ctc cca gct gag acg gag ctg acg gtc gcc gta ttt gat cat   4717
Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His
                1540                1545                1550
 
gac ctc gtg ggt tct gac gac ctc atc ggg gag acc cac att gat ctg   4765
Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu
            1555                1560                1565
 
gaa aac cga ttc tat agc cac cac aga gca aac tgt ggg ctg gcc tcc   4813
Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser
        1570                1575                1580
 
cag tat gaa gta gat ggt tac aat gcc tgg cgt gat gca ttc tgg cct   4861
Gln Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro
    1585                1590                1595
 
tcg cag atc ctg gcg ggg ctg tgc caa cgc tgt ggc ctc cct gcc cct   4909
Ser Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro
1600                1605                1610                1615
 
gaa tac cga gcc ggt gct gtc aag gtg ggc agc aaa gtc ttc ctg aca   4957
Glu Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr
                1620                1625                1630
 
cca ccg gag acc ctg ccc cca gtg gcg agc ggg gac cct gaa gag gcc   5005
Pro Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala
            1635                1640                1645
 
cag gca ttg ctt gtg ctg cgg cgc tgg cag gaa atg ccg ggt ttt ggg   5053
Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly
        1650                1655                1660
 
atc cag ctg gta ccc gag cat gta gaa acc agg cct ctc tac cat ccc   5101
Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro
    1665                1670                1675
 
cac agc cca ggg ctg cta cag gga tct ctt cac atg tgg att gac atc   5149
His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile
1680                1685                1690                1695
 
ttt cct caa gat gtg cct gct cca ccc cca gtt gac atc aag cct cgg   5197
Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg
                1700                1705                1710
 
cag cca atc agc tat gag ctc aga gtt gtc atc tgg aac acg gag gat   5245
Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp
            1715                1720                1725
 
gtg gtt ctg gat gac gag aat cca ctc acc gga gag atg tcg agt gac   5293
Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp
        1730                1735                1740
 
atc tat gtg aag agc tgg gtg aag ggg ttg gag cat gac aag cag gag   5341
Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu
    1745                1750                1755
 
aca gac gtt cac ttc aac tcc ctg act ggg gag ggg aac ttc aat tgg   5389
Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp
1760                1765                1770                1775
 
cgc ttt gtg ttc cgc ttt gac tac ctg ccc acg gag cgg gag gtg agc   5437
Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser
                1780                1785                1790
 
gtc tgg cgc agg tct gga ccc ttt gcc ctg gag gag gcg gag ttc cgg   5485
Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg
            1795                1800                1805
 
cag cct gca gtg ctg gtc ctg cag gtc tgg gac tat gac cgc atc tct   5533
Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser
        1810                1815                1820
 
gcc aat gac ttc ctt gga tcc ctg gag ttg cag cta cca gac atg gtg   5581
Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val
    1825                1830                1835
 
cgt ggg gcc cgg ggc ccc gag ctc tgc tct gtg cag ctg gcc cgc aat   5629
Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn
1840                1845                1850                1855
 
ggg gcc ggg ccg agg tgc aat ctg ttt cgc tgc cgc cgc ctg agg ggc   5677
Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly
                1860                1865                1870
 
tgg tgg ccg gta gtg aag ctg aag gag gca gag gac ggc aag gtg gag   5725
Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu
            1875                1880                1885
 
gca gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg   5773
Ala Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val
        1890                1895                1900
 
ggg aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc   5821
Gly Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro
    1905                1910                1915
 
aaa act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc   5869
Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe
1920                1925                1930                1935
 
ttc atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg   5917
Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val
                1940                1945                1950
 
ctg ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag   5965
Leu Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln
            1955                1960                1965
 
atc agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgctga        6011
Ile Ser Gln Val Ile Phe Arg Pro Leu His Lys  *
        1970                1975
 
ccttggacac tcacccaggg tgccaaccct tcaatgcctg ctcctggaag tctttcttac 6071
ccatgtgagc taccccagag tctagtgctt cctctgaata aacctatcac agcc       6125

<210> 33
<211> 1978
<212> PRT
<213> Homo sapiens

<400> 33
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val
            1380                1385                1390        
Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu
        1395                1400                1405            
Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu
    1410                1415                1420                
Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser
1425                1430                1435                1440
Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu
                1445                1450                1455    
Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro
            1460                1465                1470        
Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala
        1475                1480                1485            
Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val
    1490                1495                1500                
Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile
1505                1510                1515                1520
Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile
                1525                1530                1535    
Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp
            1540                1545                1550        
Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu
        1555                1560                1565            
Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln
    1570                1575                1580                
Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser
1585                1590                1595                1600
Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu
                1605                1610                1615    
Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro
            1620                1625                1630        
Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln
        1635                1640                1645            
Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile
    1650                1655                1660                
Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His
1665                1670                1675                1680
Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe
                1685                1690                1695    
Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln
            1700                1705                1710        
Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val
        1715                1720                1725            
Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile
    1730                1735                1740                
Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr
1745                1750                1755                1760
Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg
                1765                1770                1775    
Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val
            1780                1785                1790        
Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln
        1795                1800                1805            
Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala
    1810                1815                1820                
Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg
1825                1830                1835                1840
Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly
                1845                1850                1855    
Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp
            1860                1865                1870        
Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala
        1875                1880                1885            
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    1890                1895                1900                
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
1905                1910                1915                1920
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                1925                1930                1935    
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            1940                1945                1950        
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        1955                1960                1965            
Ser Gln Val Ile Phe Arg Pro Leu His Lys
    1970                1975            


<210> 34
<211> 6245
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (65)...(6121)

<400> 34
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gacc atg gct ctg acg gta agc gtg caa cga cta aca ggg ctg acc ggc  109
     Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly
      1               5                   10                  15
 
acc cac gac cga caa gtg aag ctc acc ttt cga ggc ttt acc cag aaa   157
Thr His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys
                 20                  25                  30
 
aca aga aaa att cac tgt ggt cca gaa gca gat atc ggt gag ctg ttc   205
Thr Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe
             35                  40                  45
 
cga tgg ccc cac tat ggg gct cca ctg gct ggg gag tgt ctg tct gtg   253
Arg Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val
         50                  55                  60
 
cag gtg gtc aac tgc agc cgt gta ttc agc ctt agg cct cta ggg acc   301
Gln Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr
     65                  70                  75
 
ctg gtg atc tcc ctg cag cag cta cag aat gct ggg cat ttg gtg cta   349
Leu Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu
 80                  85                  90                  95
 
cgg gaa gcc cta gtg gat gag aat ctt caa gtg tcc ccg atc cag gtg   397
Arg Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val
                100                 105                 110
 
gag ctt gac ctg aag tac cag ccc cca gag ggc gct act gga gcc tgg   445
Glu Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp
            115                 120                 125
 
tca gag gag gac ttt ggg gca ccc atc cag gac agc ttc gag tta atc   493
Ser Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile
        130                 135                 140
 
atc ccc aat gtg ggc ttc cag gaa ctg gag cct ggg gag gcc cag ctg   541
Ile Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu
    145                 150                 155
 
gag cgg cgg gca gtg gct cta ggc cgc agg cta gct cga agt cta ggc   589
Glu Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly
160                 165                 170                 175
 
cag cag gac gat gaa gag aat gag ctg gag ctt gag ctg gag cag gac   637
Gln Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp
                180                 185                 190
 
ctg gat gat gag cct gac gtg gaa ctt tct ggt gtt atg ttc agc ccc   685
Leu Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro
            195                 200                 205
 
ctc aag agc cgc gcc agg gcc ctg gcc cat ggg gat ccc ttc cag gtg   733
Leu Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val
        210                 215                 220
 
tcc aga gct caa gac ttc cag gtg gga gtc act gtg ctg gaa gcc cag   781
Ser Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln
    225                 230                 235
 
aaa ctg gtg gga gtc aac att aac ccc tat gtg gcc gtg caa gtg ggg   829
Lys Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly
240                 245                 250                 255
 
ggg cag cgc cgt gtg acc gcc aca cag cgt ggg acc agt tgc ccc ttc   877
Gly Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe
                260                 265                 270
 
tac aat gag tac ttc ttg ttc gaa ttt cat gac acg cgg ctt cgt ctc   925
Tyr Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu
            275                 280                 285
 
caa gac ttg ctg ctg gag atc acg gtg agt ggg gta ggg gtg acc agt   973
Gln Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser
        290                 295                 300
 
gtc ctt cag aga agg ggg gat gag aaa gct gca gga cta aca cca cct   1021
Val Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro
    305                 310                 315
 
tcc ccc aag gct ttc cat tcg cag acc ctc ccc ttt atg gcc acc cgg   1069
Ser Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg
320                 325                 330                 335
 
ata ggc acc ttc agg atg gac ctg ggc atc atc ttg gac cag cca gat   1117
Ile Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp
                340                 345                 350
 
ggc cag ttc tac caa aga tgg gtt ccg ctg cat gat ccc cga gac acc   1165
Gly Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr
            355                 360                 365
 
cgc gcc ggg acc aag ggt ttc att aag gtc acc ttg tcc gtg agg gcg   1213
Arg Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala
        370                 375                 380
 
cgc ggg gac ctg ccc cct cca atg cta ccc ccg gcc cca ggg cac tgt   1261
Arg Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys
    385                 390                 395
 
tcg gac atc gag aag aac ctg ctc ctg ccg cgc ggg gtg ccc gcc gag   1309
Ser Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu
400                 405                 410                 415
 
agg cca tgg gcg cgg ctc cgc gtg cgc ctg tac cgc gcc gag ggg ctt   1357
Arg Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu
                420                 425                 430
 
ccc gcg ctg cgc ctg ggg ctg ctg ggc agc ctg gtc cgc gcc ctg cac   1405
Pro Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His
            435                 440                 445
 
gac cag cgc gtc ctg gtg gag ccc tat gtg cgg gtg tct ttc ctg ggg   1453
Asp Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly
        450                 455                 460
 
cag gag ggc gag acg tcg gtg agc gcc gag gcg gcg gcg ccc gaa tgg   1501
Gln Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp
    465                 470                 475
 
aac gag cag ctg agc ttc gtg gag ctc ttc ccg ccg ctg acg cgc agc   1549
Asn Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser
480                 485                 490                 495
 
ctc cgc ctg cag ctg cgg gac gac gcg ccc ctg gtc gac gcg gca ctc   1597
Leu Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu
                500                 505                 510
 
gct acg cac gtg ccg gac ctg agg cgg atc tcc cat ccg ggc cgc gcg   1645
Ala Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala
            515                 520                 525
 
gcg ggg ttt aac cct acc ttc ggc ccg gcc tgg gtg ccc ctc tat ggc   1693
Ala Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly
        530                 535                 540
 
tcg ccc ccc ggc gcg ggg ctc cgg gat agt ctt caa ggt ctc aac gaa   1741
Ser Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu
    545                 550                 555
 
ggc gtt ggc caa ggc att tgg ttc cgc ggc cgc ctt ctg ctg gct gtg   1789
Gly Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val
560                 565                 570                 575
 
tcc atg cag gtg ttg gaa ggg aga gct gaa cct gag cct ccc cag gcc   1837
Ser Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala
                580                 585                 590
 
cag cag ggg tcc acg ttg tcc cgg ctc acc cga aag aag aaa aag aaa   1885
Gln Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys
            595                 600                 605
 
gcc aga agg gat cag acc cca aag gcg gtt ccg cag cac ttg gac gcc   1933
Ala Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala
        610                 615                 620
 
agc ccc ggt gcc gag ggg cct gag atc ccc cgt gcc atg gag gtg gag   1981
Ser Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu
    625                 630                 635
 
gtg gag gag ctg ctg ccg ctg cca gag aat gtc ctg gcg ccc tgt gaa   2029
Val Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu
640                 645                 650                 655
 
gat ttc ctg ctt ttc ggt gtg ctc ttc gag gcc acc atg atc gac ccc   2077
Asp Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro
                660                 665                 670
 
acc gtg gcc tcc cag ccc atc agc ttc gag atc tcc att ggt cgc gca   2125
Thr Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala
            675                 680                 685
 
ggc cgt ctg gag gag caa ttg ggc cga ggg tcc agg gct ggg gag gga   2173
Gly Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly
        690                 695                 700
 
act gag ggt gca gcc gtg gag gct cag cct ctg ctg gga gcc agg cca   2221
Thr Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro
    705                 710                 715
 
gag gag gag aaa gag gag gaa gaa ctg ggg acc cat gct cag cgg cct   2269
Glu Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro
720                 725                 730                 735
 
gag ccc atg gac ggc agt ggg cca tac ttc tgc ttg ccc ctc tgt cac   2317
Glu Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His
                740                 745                 750
 
tgc aag cca tgc atg cat gtg tgg agt tgc tgg gag gac cac acc tgg   2365
Cys Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp
            755                 760                 765
 
cgc ctg cag agc agc aac tgc gtg cgc aaa gtg gcc gag agg ctg gac   2413
Arg Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp
        770                 775                 780
 
cag ggg ctg cag gag gtt gag aga ctg cag cgc aag ccg ggg cct ggc   2461
Gln Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly
    785                 790                 795
 
gcc tgt gca cag ctc aag cag gca ctg gaa gta ctg gtg gct ggg agc   2509
Ala Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser
800                 805                 810                 815
 
aga cag ttt tgc cac ggt gcc gag cgc agg acg atg acc cgg ccc aat   2557
Arg Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn
                820                 825                 830
 
gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg cac agc ctg aac ctt   2605
Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu
            835                 840                 845
 
ttg gct aag caa gga ctg cga ctt cta cgc ggc ctg aga cgg cgc aat   2653
Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn
        850                 855                 860
 
gtg caa aag aag gtg gca ctg gcc aag aag ctc ctg gca aaa ctg cgc   2701
Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg
    865                 870                 875
 
ttt ctg gct gag gag ccc cag cca ccc ctc ccc gat gtg ctg gtc tgg   2749
Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp
880                 885                 890                 895
 
atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc cgg atc cct gcc cag   2797
Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln
                900                 905                 910
 
gat gtg ctg ttc tct gtg gtt gag gag gaa cgg ggc cga gac tgt ggg   2845
Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly
            915                 920                 925
 
aag atc cag agt cta atg ctc acg gca ccc ggg gca gcc cct ggt gag   2893
Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu
        930                 935                 940
 
gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg ggc ctg ggc aag caa   2941
Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln
    945                 950                 955
 
gcc aag gcc tgc acc tct gag ctg ccc ccg gat ttg ctg ccc gag ccc   2989
Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro
960                 965                 970                 975
 
tca gcc ggg ctg ccc tcc agc cta cac cgg gac gac ttt agc tac ttc   3037
Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe
                980                 985                 990
 
caa ctc cgg gct cac ttg tac cag gcc cgg ggt gtg ttg gct gca gat   3085
Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp
             995                1000                1005
 
gac agt ggc ctc tcg gac ccc ttt gct cga gtc ctc atc tct acc cag   3133
Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln
        1010                1015                1020
 
tgt cag acc aca cgg gtc ctg gag cag acg ctg agc cct ctg tgg gat   3181
Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp
    1025                1030                1035
 
gaa ctc ctg gta ttt gag cag ttg atc gtg gat ggg agg agg gag cac   3229
Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His
1040                1045                1050                1055
 
ctg cag gag gag cct cca tta gtg atc atc aat gta ttt gac cac aat   3277
Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn
                1060                1065                1070
 
aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca ctg gcc gcc cca agg   3325
Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg
            1075                1080                1085
 
gta aag ctg atg gag gac cca tac caa cgc cca gag ttg cag ttc ttc   3373
Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe
        1090                1095                1100
 
ccc ctg agg aag gga ccc tgg gca gcc gga gag ctc att gcc gcc ttt   3421
Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe
    1105                1110                1115
 
caa ctc att gaa cta gac tac agt ggc cga ctt gag ccc tca gtg ccc   3469
Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro
1120                1125                1130                1135
 
agt gag gtg gag ccc cag gat ctg gca ccc ctg gtt gag ccc cac tct   3517
Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser
                1140                1145                1150
 
gga cgc ctg tcc ctt cca ccc aac gtg tgc cca gtg ctc agg gag ttc   3565
Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe
            1155                1160                1165
 
cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga ctt ggt cgt gtg cat   3613
Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His
        1170                1175                1180
 
ctg ctc gag gtg gag cag ccc cag gtt gta ctg gag gtg gct ggg caa   3661
Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln
    1185                1190                1195
 
ggt gtg gag tct gag gtc ctg gcc agc tac cgt gag agc ccc aat ttc   3709
Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe
1200                1205                1210                1215
 
act gag ctt gtc agg cat ctg aca gtg gac ttg ccg gag cag cct tac   3757
Thr Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr
                1220                1225                1230
 
ttg cag cct cca ctc agc atc ttg gtg att gag cgc cgg gcc ttt ggc   3805
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
            1235                1240                1245
 
cac aca gtc ctt gtg ggt tcc cac att gtc ccc cac atg ctg cga ttc   3853
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
        1250                1255                1260
 
aca ttt cgg ggt cat gag gat cct cct gag gag gaa gga gag atg gag   3901
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
    1265                1270                1275
 
gag aca ggg gat atg atg ccc aag gga cct caa gga cag aag tcc ctg   3949
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
1280                1285                1290                1295
 
gat ccc ttc ttg gct gaa gcg ggt ata tcc aga cag ctc ctg aag cct   3997
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro
                1300                1305                1310
 
cct ctg aag aag ctc cca cta gga ggc ctc cta aat caa ggc cct ggg   4045
Pro Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly
            1315                1320                1325
 
ctg gag gaa gac atc cca gat cca gag gag ctc gac tgg ggg tcc aag   4093
Leu Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys
        1330                1335                1340
 
tac tat gcg tcg ctg cag gag ctc cag ggg cag cac aac ttt gat gaa   4141
Tyr Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu
    1345                1350                1355
 
gat gaa atg gat gat cct gga gat tca gat ggg gtc aac ctc att tct   4189
Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser
1360                1365                1370                1375
 
atg gtt ggg gag atc caa gac cag ggt gag gct gaa gtc aaa ggc act   4237
Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr
                1380                1385                1390
 
gtg tcc cca aaa aaa gca gtt gcc acc ctg aag atc tac aac agg tcc   4285
Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser
            1395                1400                1405
 
ctg gag gaa gaa ttt aac cac ttt gaa gac tgg ctg aat gtg ttt cct   4333
Leu Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro
        1410                1415                1420
 
ctg tac cga ggg caa ggg ggc cag gat gga ggt gga gaa gag gaa gga   4381
Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly
    1425                1430                1435
 
tct gga cac ctt gtg ggc aag ttc aag ggc tcc ttc ctc att tac cct   4429
Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro
1440                1445                1450                1455
 
gaa tca gag gca gtg ttg ttc tct gag ccc cag atc tcc cgg ggg atc   4477
Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile
                1460                1465                1470
 
cca cag aac cgg ccc atc aag ctc ctg gtc aga gtg tat gtt gta aag   4525
Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys
            1475                1480                1485
 
gct acc aac ctg gct cct gca gac ccc aat ggc aaa gca gac cct tac   4573
Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr
        1490                1495                1500
 
gtg gtg gtg agc gct ggc cgg gag cgg cag gac acc aag gaa cgc tac   4621
Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr
    1505                1510                1515
 
atc ccc aag cag ctc aac ccc atc ttt gga gag atc ctg gag cta agc   4669
Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser
1520                1525                1530                1535
 
atc tct ctc cca gct gag acg gag ctg acg gtc gcc gta ttt gat cat   4717
Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His
                1540                1545                1550
 
gac ctc gtg ggt tct gac gac ctc atc ggg gag acc cac att gat ctg   4765
Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu
            1555                1560                1565
 
gaa aac cga ttc tat agc cac cac aga gca aac tgt ggg ctg gcc tcc   4813
Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser
        1570                1575                1580
 
cag tat gaa gta gat ggt tac aat gcc tgg cgt gat gca ttc tgg cct   4861
Gln Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro
    1585                1590                1595
 
tcg cag atc ctg gcg ggg ctg tgc caa cgc tgt ggc ctc cct gcc cct   4909
Ser Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro
1600                1605                1610                1615
 
gaa tac cga gcc ggt gct gtc aag gtg ggc agc aaa gtc ttc ctg aca   4957
Glu Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr
                1620                1625                1630
 
cca ccg gag acc ctg ccc cca gtg gcg agc ggg gac cct gaa gag gcc   5005
Pro Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala
            1635                1640                1645
 
cag gca ttg ctt gtg ctg cgg cgc tgg cag gaa atg ccg ggt ttt ggg   5053
Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly
        1650                1655                1660
 
atc cag ctg gta ccc gag cat gta gaa acc agg cct ctc tac cat ccc   5101
Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro
    1665                1670                1675
 
cac agc cca ggg ctg cta cag gga tct ctt cac atg tgg att gac atc   5149
His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile
1680                1685                1690                1695
 
ttt cct caa gat gtg cct gct cca ccc cca gtt gac atc aag cct cgg   5197
Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg
                1700                1705                1710
 
cag cca atc agc tat gag ctc aga gtt gtc atc tgg aac acg gag gat   5245
Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp
            1715                1720                1725
 
gtg gtt ctg gat gac gag aat cca ctc acc gga gag atg tcg agt gac   5293
Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp
        1730                1735                1740
 
atc tat gtg aag agc tgg gtg aag ggg ttg gag cat gac aag cag gag   5341
Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu
    1745                1750                1755
 
aca gac gtt cac ttc aac tcc ctg act ggg gag ggg aac ttc aat tgg   5389
Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp
1760                1765                1770                1775
 
cgc ttt gtg ttc cgc ttt gac tac ctg ccc acg gag cgg gag gtg agc   5437
Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser
                1780                1785                1790
 
gtc tgg cgc agg tct gga ccc ttt gcc ctg gag gag gcg gag ttc cgg   5485
Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg
            1795                1800                1805
 
cag cct gca gtg ctg gtc ctg cag gtc tgg gac tat gac cgc atc tct   5533
Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser
        1810                1815                1820
 
gcc aat gac ttc ctt gga tcc ctg gag ttg cag cta cca gac atg gtg   5581
Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val
    1825                1830                1835
 
cgt ggg gcc cgg ggc ccc gag ctc tgc tct gtg cag ctg gcc cgc aat   5629
Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn
1840                1845                1850                1855
 
ggg gcc ggg ccg agg tgc aat ctg ttt cgc tgc cgc cgc ctg agg ggc   5677
Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly
                1860                1865                1870
 
tgg tgg ccg gta gtg aag ctg aag gag gca gag gac gtg gag cgg gag   5725
Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg Glu
            1875                1880                1885
 
gcg cag gag gct cag gct ggc aag aag aag cga aag cag agg agg agg   5773
Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg Arg
        1890                1895                1900
 
aag ggc cgg cca gaa gac ctg gag ttc aca gac atg ggt ggc aat gtg   5821
Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn Val
    1905                1910                1915
 
tac atc ctc acg ggc aag gtg gag gca gag ttt gag ctg ctg act gtg   5869
Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr Val
1920                1925                1930                1935
 
gag gag gcc gag aaa cgg cca gtg ggg aag ggg cgg aag cag cca gag   5917
Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro Glu
                1940                1945                1950
 
cct ctg gag aaa ccc agc cgc ccc aaa act tcc ttc aac tgg ttt gtg   5965
Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe Val
            1955                1960                1965
 
aac ccg ctg aag acc ttt gtc ttc ttc atc tgg cgc cgg tac tgg cgc   6013
Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg
        1970                1975                1980
 
acc ctg gtg ctg ctg cta ctg gtg ctg ctc acc gtc ttc ctc ctc ctg   6061
Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu Leu
    1985                1990                1995
 
gtc ttc tac acc atc cct ggc cag atc agc cag gtc atc ttc cgt ccc   6109
Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg Pro
2000                2005                2010                2015
 
ctc cac aag tga ctctcgctga ccttggacac tcacccaggg tgccaaccct       6161
Leu His Lys  *

 
tcaatgcctg ctcctggaag tctttcttac ccatgtgagc taccccagag tctagtgctt 6221
cctctgaata aacctatcac agcc                                        6245

<210> 35
<211> 2018
<212> PRT
<213> Homo sapiens

<400> 35
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val
            1380                1385                1390        
Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu
        1395                1400                1405            
Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu
    1410                1415                1420                
Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser
1425                1430                1435                1440
Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu
                1445                1450                1455    
Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro
            1460                1465                1470        
Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala
        1475                1480                1485            
Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val
    1490                1495                1500                
Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile
1505                1510                1515                1520
Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile
                1525                1530                1535    
Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp
            1540                1545                1550        
Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu
        1555                1560                1565            
Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln
    1570                1575                1580                
Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser
1585                1590                1595                1600
Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu
                1605                1610                1615    
Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro
            1620                1625                1630        
Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln
        1635                1640                1645            
Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile
    1650                1655                1660                
Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His
1665                1670                1675                1680
Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe
                1685                1690                1695    
Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln
            1700                1705                1710        
Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val
        1715                1720                1725            
Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile
    1730                1735                1740                
Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr
1745                1750                1755                1760
Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg
                1765                1770                1775    
Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val
            1780                1785                1790        
Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln
        1795                1800                1805            
Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala
    1810                1815                1820                
Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg
1825                1830                1835                1840
Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly
                1845                1850                1855    
Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp
            1860                1865                1870        
Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg Glu Ala
        1875                1880                1885            
Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys
    1890                1895                1900                
Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn Val Tyr
1905                1910                1915                1920
Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr Val Glu
                1925                1930                1935    
Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro
            1940                1945                1950        
Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn
        1955                1960                1965            
Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr
    1970                1975                1980                
Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu Leu Val
1985                1990                1995                2000
Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu
                2005                2010                2015    
His Lys
        


<210> 36
<211> 328
<212> PRT
<213> Homo sapiens

<400> 36
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 37
<211> 236
<212> PRT
<213> Homo sapiens

<400> 37
Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val
 1               5                  10                  15      
Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser
            20                  25                  30          
Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu
        35                  40                  45              
Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr
    50                  55                  60                  
Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly
65                  70                  75                  80  
His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser
                85                  90                  95      
Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln
            100                 105                 110         
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr
        115                 120                 125             
Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val
    130                 135                 140                 
Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro
145                 150                 155                 160 
Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser
                165                 170                 175     
Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu
            180                 185                 190         
Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn
        195                 200                 205             
Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr
    210                 215                 220                 
Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
225                 230                 235     


<210> 38
<211> 181
<212> PRT
<213> Homo sapiens

<400> 38
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 39
<211> 328
<212> PRT
<213> Homo sapiens

<400> 39
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Arg Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 40
<211> 328
<212> PRT
<213> Homo sapiens

<400> 40
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Ile Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 41
<211> 178
<212> PRT
<213> Homo sapiens

<400> 41
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Leu Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Thr Ala Ser Leu Pro Met Thr Ser Leu Asp Pro Trp Ser Cys Ser
    130                 135                 140                 
Tyr Gln Thr Trp Cys Val Gly Pro Gly Ala Pro Ser Ser Ala Leu Cys
145                 150                 155                 160 
Ser Trp Pro Ala Met Gly Pro Gly Arg Gly Ala Ile Cys Phe Ala Ala
                165                 170                 175     
Ala Ala
        


<210> 42
<211> 181
<212> PRT
<213> Homo sapiens

<400> 42
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 43
<211> 328
<212> PRT
<213> Homo sapiens

<400> 43
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Arg Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 44
<211> 328
<212> PRT
<213> Homo sapiens

<400> 44
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 45
<211> 328
<212> PRT
<213> Homo sapiens

<400> 45
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Asn Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 46
<211> 328
<212> PRT
<213> Homo sapiens

<400> 46
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Ala Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 47
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 47
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly Arg
            1380                1385                1390        
Ile
    


<210> 48
<211> 1145
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly
                885                 890                 895     
Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp
            900                 905                 910         
Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val
        915                 920                 925             
Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His
    930                 935                 940                 
Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly
945                 950                 955                 960 
Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys
                965                 970                 975     
Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe
            980                 985                 990         
Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys
        995                 1000                1005            
Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile
    1010                1015                1020                
Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala
1025                1030                1035                1040
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
                1045                1050                1055    
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
            1060                1065                1070        
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
        1075                1080                1085            
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
    1090                1095                1100                
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
1105                1110                1115                1120
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp
                1125                1130                1135    
Val Gln Gln Gly Pro Gln Glu Pro Phe
            1140                1145


<210> 49
<211> 1990
<212> PRT
<213> Homo sapiens

<400> 49
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
    1650                1655                1660                
Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro
1665                1670                1675                1680
Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu
                1685                1690                1695    
Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val
            1700                1705                1710        
Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr
        1715                1720                1725            
Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp
    1730                1735                1740                
Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser
1745                1750                1755                1760
Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe
                1765                1770                1775    
Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg
            1780                1785                1790        
Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser
        1795                1800                1805            
Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu
    1810                1815                1820                
Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu
1825                1830                1835                1840
Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly
                1845                1850                1855    
Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg
            1860                1865                1870        
Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val
        1875                1880                1885            
Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu Leu
    1890                1895                1900                
Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys
1905                1910                1915                1920
Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn
                1925                1930                1935    
Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg
            1940                1945                1950        
Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe
        1955                1960                1965            
Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile
    1970                1975                1980                
Phe Arg Pro Leu His Lys
1985                1990


<210> 50
<211> 2036
<212> PRT
<213> Homo sapiens

<400> 50
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu Glu
    1650                1655                1660                
Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe
1665                1670                1675                1680
Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His
                1685                1690                1695    
Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp
            1700                1705                1710        
Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro
        1715                1720                1725            
Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu
    1730                1735                1740                
Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser
1745                1750                1755                1760
Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln
                1765                1770                1775    
Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn
            1780                1785                1790        
Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val
        1795                1800                1805            
Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
    1810                1815                1820                
Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile
1825                1830                1835                1840
Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met
                1845                1850                1855    
Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg
            1860                1865                1870        
Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg
        1875                1880                1885            
Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg
    1890                1895                1900                
Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg
1905                1910                1915                1920
Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn
                1925                1930                1935    
Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr
            1940                1945                1950        
Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro
        1955                1960                1965            
Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe
    1970                1975                1980                
Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp
1985                1990                1995                2000
Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu
                2005                2010                2015    
Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg
            2020                2025                2030        
Pro Leu His Lys
        2035    


<210> 51
<211> 610
<212> PRT
<213> Homo sapiens

<400> 51
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly
                85                  90                  95      
Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val
            100                 105                 110         
Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu
        115                 120                 125             
Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu
    130                 135                 140                 
Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu
145                 150                 155                 160 
Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu
                165                 170                 175     
Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val
            180                 185                 190         
Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val
        195                 200                 205             
Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu
    210                 215                 220                 
Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu
225                 230                 235                 240 
Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu
                245                 250                 255     
Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys
            260                 265                 270         
Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr
        275                 280                 285             
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
    290                 295                 300                 
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
305                 310                 315                 320 
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
                325                 330                 335     
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
            340                 345                 350         
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His
        355                 360                 365             
Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val
    370                 375                 380                 
Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu
385                 390                 395                 400 
Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile
                405                 410                 415     
Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His Phe Glu Asp Trp Leu
            420                 425                 430         
Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly
        435                 440                 445             
Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe
    450                 455                 460                 
Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile
465                 470                 475                 480 
Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val
                485                 490                 495     
Tyr Val Val Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys
            500                 505                 510         
Ala Asp Pro Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr
        515                 520                 525             
Lys Glu Arg Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile
    530                 535                 540                 
Leu Glu Leu Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala
545                 550                 555                 560 
Val Phe Asp His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr
                565                 570                 575     
His Ile Asp Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys
            580                 585                 590         
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
        595                 600                 605             
Pro Phe
    610 


<210> 52
<211> 1978
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val
            1380                1385                1390        
Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu
        1395                1400                1405            
Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu
    1410                1415                1420                
Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser
1425                1430                1435                1440
Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu
                1445                1450                1455    
Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro
            1460                1465                1470        
Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala
        1475                1480                1485            
Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val
    1490                1495                1500                
Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile
1505                1510                1515                1520
Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile
                1525                1530                1535    
Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp
            1540                1545                1550        
Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu
        1555                1560                1565            
Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln
    1570                1575                1580                
Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser
1585                1590                1595                1600
Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu
                1605                1610                1615    
Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro
            1620                1625                1630        
Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln
        1635                1640                1645            
Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile
    1650                1655                1660                
Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His
1665                1670                1675                1680
Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe
                1685                1690                1695    
Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln
            1700                1705                1710        
Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val
        1715                1720                1725            
Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile
    1730                1735                1740                
Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr
1745                1750                1755                1760
Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg
                1765                1770                1775    
Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val
            1780                1785                1790        
Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln
        1795                1800                1805            
Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala
    1810                1815                1820                
Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg
1825                1830                1835                1840
Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly
                1845                1850                1855    
Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp
            1860                1865                1870        
Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala
        1875                1880                1885            
Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
    1890                1895                1900                
Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
1905                1910                1915                1920
Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
                1925                1930                1935    
Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
            1940                1945                1950        
Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
        1955                1960                1965            
Ser Gln Val Ile Phe Arg Pro Leu His Lys
    1970                1975            


<210> 53
<211> 2018
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val
            1380                1385                1390        
Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu
        1395                1400                1405            
Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu
    1410                1415                1420                
Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser
1425                1430                1435                1440
Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu
                1445                1450                1455    
Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro
            1460                1465                1470        
Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala
        1475                1480                1485            
Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val
    1490                1495                1500                
Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile
1505                1510                1515                1520
Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile
                1525                1530                1535    
Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp
            1540                1545                1550        
Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu
        1555                1560                1565            
Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln
    1570                1575                1580                
Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser
1585                1590                1595                1600
Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu
                1605                1610                1615    
Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro
            1620                1625                1630        
Pro Glu Thr Leu Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln
        1635                1640                1645            
Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile
    1650                1655                1660                
Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His
1665                1670                1675                1680
Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe
                1685                1690                1695    
Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln
            1700                1705                1710        
Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val
        1715                1720                1725            
Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile
    1730                1735                1740                
Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr
1745                1750                1755                1760
Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg
                1765                1770                1775    
Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val
            1780                1785                1790        
Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln
        1795                1800                1805            
Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala
    1810                1815                1820                
Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg
1825                1830                1835                1840
Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly
                1845                1850                1855    
Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp
            1860                1865                1870        
Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg Glu Ala
        1875                1880                1885            
Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys
    1890                1895                1900                
Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn Val Tyr
1905                1910                1915                1920
Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr Val Glu
                1925                1930                1935    
Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro
            1940                1945                1950        
Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn
        1955                1960                1965            
Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr
    1970                1975                1980                
Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu Leu Val
1985                1990                1995                2000
Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu
                2005                2010                2015    
His Lys
        


<210> 54
<211> 328
<212> PRT
<213> Homo sapiens

<400> 54
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 55
<211> 236
<212> PRT
<213> Homo sapiens

<400> 55
Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val
 1               5                  10                  15      
Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser
            20                  25                  30          
Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu
        35                  40                  45              
Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr
    50                  55                  60                  
Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly
65                  70                  75                  80  
His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser
                85                  90                  95      
Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln
            100                 105                 110         
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr
        115                 120                 125             
Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val
    130                 135                 140                 
Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro
145                 150                 155                 160 
Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser
                165                 170                 175     
Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu
            180                 185                 190         
Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn
        195                 200                 205             
Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr
    210                 215                 220                 
Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
225                 230                 235     


<210> 56
<211> 181
<212> PRT
<213> Homo sapiens

<400> 56
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 57
<211> 178
<212> PRT
<213> Homo sapiens

<400> 57
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Leu Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Thr Ala Ser Leu Pro Met Thr Ser Leu Asp Pro Trp Ser Cys Ser
    130                 135                 140                 
Tyr Gln Thr Trp Cys Val Gly Pro Gly Ala Pro Ser Ser Ala Leu Cys
145                 150                 155                 160 
Ser Trp Pro Ala Met Gly Pro Gly Arg Gly Ala Ile Cys Phe Ala Ala
                165                 170                 175     
Ala Ala
        


<210> 58
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly Arg
            1380                1385                1390        
Ile
    


<210> 59
<211> 1145
<212> PRT
<213> Homo sapiens

<400> 59
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly
                885                 890                 895     
Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp
            900                 905                 910         
Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val
        915                 920                 925             
Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His
    930                 935                 940                 
Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly
945                 950                 955                 960 
Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys
                965                 970                 975     
Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe
            980                 985                 990         
Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys
        995                 1000                1005            
Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile
    1010                1015                1020                
Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala
1025                1030                1035                1040
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
                1045                1050                1055    
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
            1060                1065                1070        
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
        1075                1080                1085            
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
    1090                1095                1100                
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
1105                1110                1115                1120
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp
                1125                1130                1135    
Val Gln Gln Gly Pro Gln Glu Pro Phe
            1140                1145


<210> 60
<211> 1990
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
    1650                1655                1660                
Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro
1665                1670                1675                1680
Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu
                1685                1690                1695    
Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val
            1700                1705                1710        
Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr
        1715                1720                1725            
Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp
    1730                1735                1740                
Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser
1745                1750                1755                1760
Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe
                1765                1770                1775    
Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg
            1780                1785                1790        
Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser
        1795                1800                1805            
Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu
    1810                1815                1820                
Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu
1825                1830                1835                1840
Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly
                1845                1850                1855    
Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg
            1860                1865                1870        
Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val
        1875                1880                1885            
Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu Leu
    1890                1895                1900                
Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys
1905                1910                1915                1920
Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn
                1925                1930                1935    
Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg
            1940                1945                1950        
Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe
        1955                1960                1965            
Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile
    1970                1975                1980                
Phe Arg Pro Leu His Lys
1985                1990


<210> 61
<211> 2036
<212> PRT
<213> Homo sapiens

<400> 61
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu Glu
    1650                1655                1660                
Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe
1665                1670                1675                1680
Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His
                1685                1690                1695    
Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp
            1700                1705                1710        
Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro
        1715                1720                1725            
Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu
    1730                1735                1740                
Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser
1745                1750                1755                1760
Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln
                1765                1770                1775    
Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn
            1780                1785                1790        
Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val
        1795                1800                1805            
Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
    1810                1815                1820                
Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile
1825                1830                1835                1840
Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met
                1845                1850                1855    
Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg
            1860                1865                1870        
Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg
        1875                1880                1885            
Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg
    1890                1895                1900                
Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg
1905                1910                1915                1920
Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn
                1925                1930                1935    
Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr
            1940                1945                1950        
Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro
        1955                1960                1965            
Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe
    1970                1975                1980                
Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp
1985                1990                1995                2000
Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu
                2005                2010                2015    
Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg
            2020                2025                2030        
Pro Leu His Lys
        2035    


<210> 62
<211> 610
<212> PRT
<213> Homo sapiens

<400> 62
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly
                85                  90                  95      
Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val
            100                 105                 110         
Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu
        115                 120                 125             
Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu
    130                 135                 140                 
Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu
145                 150                 155                 160 
Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu
                165                 170                 175     
Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val
            180                 185                 190         
Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val
        195                 200                 205             
Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu
    210                 215                 220                 
Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu
225                 230                 235                 240 
Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu
                245                 250                 255     
Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys
            260                 265                 270         
Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr
        275                 280                 285             
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
    290                 295                 300                 
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
305                 310                 315                 320 
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
                325                 330                 335     
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
            340                 345                 350         
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His
        355                 360                 365             
Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val
    370                 375                 380                 
Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu
385                 390                 395                 400 
Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile
                405                 410                 415     
Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His Phe Glu Asp Trp Leu
            420                 425                 430         
Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly
        435                 440                 445             
Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe
    450                 455                 460                 
Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile
465                 470                 475                 480 
Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val
                485                 490                 495     
Tyr Val Val Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys
            500                 505                 510         
Ala Asp Pro Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr
        515                 520                 525             
Lys Glu Arg Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile
    530                 535                 540                 
Leu Glu Leu Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala
545                 550                 555                 560 
Val Phe Asp His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr
                565                 570                 575     
His Ile Asp Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys
            580                 585                 590         
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
        595                 600                 605             
Pro Phe
    610 


<210> 63
<211> 14
<212> PRT
<213> Tetanus toxoid

<400> 63
Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu
 1               5                  10                  


<210> 64
<211> 21
<212> PRT
<213> Plasmodium falciparum

<400> 64
Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe
 1               5                  10                  15      
Asn Val Val Asn Ser
            20      


<210> 65
<211> 16
<212> PRT
<213> Streptococcus

<400> 65
Gly Ala Val Asp Ser Ile Leu Gly Gly Val Ala Thr Tyr Gly Ala Ala
 1               5                  10                  15      


<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pan-DR Binding Epitope

<221> VARIANT        
<222> 3
<223> Xaa = cyclohexyalanine, phenylalanine, or tyrosine

<221> VARIANT        
<222> 1, 13
<223> Xaa = d-alanine or I-alanine

<400> 66
Xaa Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Xaa
 1               5                  10              


<210> 67
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 67
ttttgatcaa gctt                                                   14

<210> 68
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 68
ctaatacgac tcactatagg gctcgagcgg ccgcccgggc ag                    42

<210> 69
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 69
gatcctgccc gg                                                     12

<210> 70
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 70
gtaatacgac tcactatagg gcagcgtggt cgcggccgag                       40

<210> 71
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 71
gatcctcggc                                                        10

<210> 72
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 72
ctaatacgac tcactatagg gc                                          22

<210> 73
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 73
tcgagcggcc gcccgggcag ga                                          22

<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 74
agcgtggtcg cggccgagga                                             20

<210> 75
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 75
atatcgccgc gctcgtcgtc gacaa                                       25

<210> 76
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 76
agccacacgc agctcattgt agaagg                                      26

<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 77
catctatgtg aagagctggg tgaa                                        24

<210> 78
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 78
aggtagtcaa agcggaacac aaag                                        24

<210> 79
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 79
gtcctcccag caactccaca ca                                          22

<210> 80
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 80
tgtcccttcc acccaacgtg tgc                                         23

<210> 81
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 81
tcctccatct ctccttcctc ctcag                                       25

<210> 82
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 82
cagaaactgg tgggagtcaa ca                                          22

<210> 83
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 83
atggctctga cggtaagcgt gc                                          22

<210> 84
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 84
ataggcacct tcaggatgga cc                                          22

<210> 85
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 85
tccatcctga aggtgcctat cc                                          22

<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 86
cagaggagga gaaagaggag g                                           21

<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 87
tcctctttct cctcctctgg                                             20

<210> 88
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 88
agatccagag tctaatgctc acg                                         23

<210> 89
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 89
cgtgagcatt agactctgga tc                                          22

<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 90
aaggtgtgga gtctgaggtc                                             20

<210> 91
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 91
acctcagact ccacaccttg c                                           21

<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 92
actctgacca ggagcttgat g                                           21

<210> 93
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 93
acacggagga tgtggttctg g                                           21

<210> 94
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 94
ttgagctgct gactgtggag gag                                         23

<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 95
tcctccacag tcagcagctc                                             20

<210> 96
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 96
tgagtgtcca aggtcagcga g                                           21

<210> 97
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 97
agagaatgag ctggagcttg agc                                         23

<210> 98
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 98
tcaagctcca gctcattctc ttc                                         23

<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 99
taacaccaga aagttccacg tcag                                        24

<210> 100
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 100
tgacggtcgc cgtatttgat c                                           21

<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 101
gattggctgc cgaggcttga                                             20

<210> 102
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 102
tgacggtcgc cgtatttgat c                                           21

<210> 103
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Flag Tag

<400> 103
gattacaagg atgacgacga taag                                        24

<210> 104
<211> 21
<212> DNA
<213> Homo sapiens

<400> 104
cctcggcagc caatcagcta t                                           21

<210> 105
<211> 24
<212> DNA
<213> Homo sapiens

<400> 105
aagggacgaa gacgaacacu uctt                                        24

<210> 106
<211> 23
<212> DNA
<213> Homo sapiens

<400> 106
aactgaagac ctgaagacaa taa                                         23

<210> 107
<211> 9
<212> PRT
<213> Homo sapiens

<400> 107
Ser Arg Val Phe Ser Leu Arg Pro Leu
 1               5                  


<210> 108
<211> 9
<212> PRT
<213> Homo sapiens

<400> 108
Asn Leu Gln Val Ser Pro Ile Gln Val
 1               5                  


<210> 109
<211> 9
<212> PRT
<213> Homo sapiens

<400> 109
Thr Gly Ala Trp Ser Glu Glu Asp Phe
 1               5                  


<210> 110
<211> 9
<212> PRT
<213> Homo sapiens

<400> 110
Arg Leu Ala Arg Ser Leu Gly Gln Gln
 1               5                  


<210> 111
<211> 9
<212> PRT
<213> Homo sapiens

<400> 111
Gly Val Met Phe Ser Pro Leu Lys Ser
 1               5                  


<210> 112
<211> 9
<212> PRT
<213> Homo sapiens

<400> 112
Ser Pro Leu Lys Ser Arg Ala Arg Ala
 1               5                  


<210> 113
<211> 9
<212> PRT
<213> Homo sapiens

<400> 113
Gln Arg Gly Thr Ser Cys Pro Phe Tyr
 1               5                  


<210> 114
<211> 9
<212> PRT
<213> Homo sapiens

<400> 114
Leu Thr Pro Pro Ser Pro Lys Ala Phe
 1               5                  


<210> 115
<211> 9
<212> PRT
<213> Homo sapiens

<400> 115
Lys Val Thr Leu Ser Val Arg Ala Arg
 1               5                  


<210> 116
<211> 9
<212> PRT
<213> Homo sapiens

<400> 116
Tyr Val Arg Val Ser Phe Leu Gly Gln
 1               5                  


<210> 117
<211> 9
<212> PRT
<213> Homo sapiens

<400> 117
Glu Gly Glu Thr Ser Val Ser Ala Glu
 1               5                  


<210> 118
<211> 9
<212> PRT
<213> Homo sapiens

<400> 118
Glu Thr Ser Val Ser Ala Glu Ala Ala
 1               5                  


<210> 119
<211> 9
<212> PRT
<213> Homo sapiens

<400> 119
Asn Glu Gln Leu Ser Phe Val Glu Leu
 1               5                  


<210> 120
<211> 9
<212> PRT
<213> Homo sapiens

<400> 120
Leu Arg Arg Ile Ser His Pro Gly Arg
 1               5                  


<210> 121
<211> 9
<212> PRT
<213> Homo sapiens

<400> 121
His Leu Asp Ala Ser Pro Gly Ala Glu
 1               5                  


<210> 122
<211> 9
<212> PRT
<213> Homo sapiens

<400> 122
Ser Gln Pro Ile Ser Phe Glu Ile Ser
 1               5                  


<210> 123
<211> 9
<212> PRT
<213> Homo sapiens

<400> 123
Ser Phe Glu Ile Ser Ile Gly Arg Ala
 1               5                  


<210> 124
<211> 9
<212> PRT
<213> Homo sapiens

<400> 124
Asp Val Leu Phe Ser Val Val Glu Glu
 1               5                  


<210> 125
<211> 9
<212> PRT
<213> Homo sapiens

<400> 125
Gly Leu Pro Ser Ser Leu His Arg Asp
 1               5                  


<210> 126
<211> 9
<212> PRT
<213> Homo sapiens

<400> 126
Asp Ser Gly Leu Ser Asp Pro Phe Ala
 1               5                  


<210> 127
<211> 9
<212> PRT
<213> Homo sapiens

<400> 127
Glu Leu Asp Tyr Ser Gly Arg Leu Glu
 1               5                  


<210> 128
<211> 9
<212> PRT
<213> Homo sapiens

<400> 128
Pro Ser Val Pro Ser Glu Val Glu Pro
 1               5                  


<210> 129
<211> 9
<212> PRT
<213> Homo sapiens

<400> 129
Val Glu Pro His Ser Gly Arg Leu Ser
 1               5                  


<210> 130
<211> 9
<212> PRT
<213> Homo sapiens

<400> 130
Ser Gly Arg Leu Ser Leu Pro Pro Asn
 1               5                  


<210> 131
<211> 9
<212> PRT
<213> Homo sapiens

<400> 131
Glu Val Leu Ala Ser Tyr Arg Glu Ser
 1               5                  


<210> 132
<211> 9
<212> PRT
<213> Homo sapiens

<400> 132
Ser Tyr Arg Glu Ser Pro Asn Phe Thr
 1               5                  


<210> 133
<211> 9
<212> PRT
<213> Homo sapiens

<400> 133
Asp Pro Gly Asp Ser Asp Gly Val Asn
 1               5                  


<210> 134
<211> 9
<212> PRT
<213> Homo sapiens

<400> 134
Lys Gly Thr Val Ser Pro Lys Lys Ala
 1               5                  


<210> 135
<211> 9
<212> PRT
<213> Homo sapiens

<400> 135
Ile Tyr Asn Arg Ser Leu Lys Glu Glu
 1               5                  


<210> 136
<211> 9
<212> PRT
<213> Homo sapiens

<400> 136
Tyr Val Val Val Ser Ala Gly Arg Glu
 1               5                  


<210> 137
<211> 9
<212> PRT
<213> Homo sapiens

<400> 137
Asn Arg Phe Tyr Ser His His Arg Ala
 1               5                  


<210> 138
<211> 9
<212> PRT
<213> Homo sapiens

<400> 138
Cys Gly Leu Ala Ser Gln Tyr Glu Val
 1               5                  


<210> 139
<211> 9
<212> PRT
<213> Homo sapiens

<400> 139
Leu Pro Pro Gly Ser Ser Ser Pro Thr
 1               5                  


<210> 140
<211> 9
<212> PRT
<213> Homo sapiens

<400> 140
Pro Gly Ser Ser Ser Pro Thr Val Ala
 1               5                  


<210> 141
<211> 9
<212> PRT
<213> Homo sapiens

<400> 141
Tyr His Pro His Ser Pro Gly Leu Leu
 1               5                  


<210> 142
<211> 9
<212> PRT
<213> Homo sapiens

<400> 142
Arg Gln Pro Ile Ser Tyr Glu Leu Arg
 1               5                  


<210> 143
<211> 9
<212> PRT
<213> Homo sapiens

<400> 143
Glu Arg Glu Val Ser Val Trp Arg Arg
 1               5                  


<210> 144
<211> 9
<212> PRT
<213> Homo sapiens

<400> 144
Val Trp Arg Arg Ser Gly Pro Phe Ala
 1               5                  


<210> 145
<211> 9
<212> PRT
<213> Homo sapiens

<400> 145
Tyr Asp Arg Ile Ser Ala Asn Asp Phe
 1               5                  


<210> 146
<211> 9
<212> PRT
<213> Homo sapiens

<400> 146
Leu Glu Lys Pro Ser Arg Pro Lys Thr
 1               5                  


<210> 147
<211> 9
<212> PRT
<213> Homo sapiens

<400> 147
Phe Arg Gly Phe Thr Gln Lys Thr Arg
 1               5                  


<210> 148
<211> 9
<212> PRT
<213> Homo sapiens

<400> 148
Gln Arg Arg Val Thr Ala Thr Gln Arg
 1               5                  


<210> 149
<211> 9
<212> PRT
<213> Homo sapiens

<400> 149
Arg Val Thr Ala Thr Gln Arg Gly Thr
 1               5                  


<210> 150
<211> 9
<212> PRT
<213> Homo sapiens

<400> 150
Thr Gln Arg Gly Thr Ser Cys Pro Phe
 1               5                  


<210> 151
<211> 9
<212> PRT
<213> Homo sapiens

<400> 151
Thr Arg Ile Gly Thr Phe Arg Met Asp
 1               5                  


<210> 152
<211> 9
<212> PRT
<213> Homo sapiens

<400> 152
Asp Pro Arg Asp Thr Arg Ala Gly Thr
 1               5                  


<210> 153
<211> 9
<212> PRT
<213> Homo sapiens

<400> 153
Leu Ser Arg Leu Thr Arg Lys Lys Lys
 1               5                  


<210> 154
<211> 9
<212> PRT
<213> Homo sapiens

<400> 154
Arg Arg Asp Gln Thr Pro Lys Ala Val
 1               5                  


<210> 155
<211> 9
<212> PRT
<213> Homo sapiens

<400> 155
Ala Gly Glu Gly Thr Glu Gly Ala Ala
 1               5                  


<210> 156
<211> 9
<212> PRT
<213> Homo sapiens

<400> 156
Arg Arg Thr Met Thr Arg Pro Asn Ala
 1               5                  


<210> 157
<211> 9
<212> PRT
<213> Homo sapiens

<400> 157
Val Leu Ile Ser Thr Gln Cys Gln Thr
 1               5                  


<210> 158
<211> 9
<212> PRT
<213> Homo sapiens

<400> 158
Thr Gln Cys Gln Thr Thr Arg Val Leu
 1               5                  


<210> 159
<211> 9
<212> PRT
<213> Homo sapiens

<400> 159
Val Leu Glu Gln Thr Leu Ser Pro Leu
 1               5                  


<210> 160
<211> 9
<212> PRT
<213> Homo sapiens

<400> 160
Val Arg His Leu Thr Val Val Phe Lys
 1               5                  


<210> 161
<211> 9
<212> PRT
<213> Homo sapiens

<400> 161
Lys Ala Val Ala Thr Leu Lys Ile Tyr
 1               5                  


<210> 162
<211> 9
<212> PRT
<213> Homo sapiens

<400> 162
Glu Arg Gln Asp Thr Lys Glu Arg Tyr
 1               5                  


<210> 163
<211> 9
<212> PRT
<213> Homo sapiens

<400> 163
Glu Thr Glu Leu Thr Val Ala Val Phe
 1               5                  


<210> 164
<211> 9
<212> PRT
<213> Homo sapiens

<400> 164
Lys Val Phe Leu Thr Pro Pro Glu Thr
 1               5                  


<210> 165
<211> 9
<212> PRT
<213> Homo sapiens

<400> 165
Val Ile Trp Asn Thr Glu Asp Val Val
 1               5                  


<210> 166
<211> 9
<212> PRT
<213> Homo sapiens

<400> 166
Asp Tyr Leu Pro Thr Glu Arg Glu Val
 1               5                  


<210> 167
<211> 9
<212> PRT
<213> Homo sapiens

<400> 167
Val Tyr Ile Leu Thr Gly Lys Val Glu
 1               5                  


<210> 168
<211> 9
<212> PRT
<213> Homo sapiens

<400> 168
Phe Glu Leu Leu Thr Val Glu Glu Ala
 1               5                  


<210> 169
<211> 9
<212> PRT
<213> Homo sapiens

<400> 169
Ser Arg Pro Lys Thr Ser Phe Asn Trp
 1               5                  


<210> 170
<211> 9
<212> PRT
<213> Homo sapiens

<400> 170
Arg Trp Pro His Tyr Gly Ala Pro Leu
 1               5                  


<210> 171
<211> 9
<212> PRT
<213> Homo sapiens

<400> 171
Leu Val Glu Pro Tyr Val Arg Val Ser
 1               5                  


<210> 172
<211> 9
<212> PRT
<213> Homo sapiens

<400> 172
Trp Val Pro Leu Tyr Gly Ser Pro Pro
 1               5                  


<210> 173
<211> 9
<212> PRT
<213> Homo sapiens

<400> 173
Asp Asp Phe Ser Tyr Phe Gln Leu Arg
 1               5                  


<210> 174
<211> 9
<212> PRT
<213> Homo sapiens

<400> 174
Met Glu Asp Pro Tyr Gln Arg Pro Glu
 1               5                  


<210> 175
<211> 9
<212> PRT
<213> Homo sapiens

<400> 175
Pro Glu Gln Pro Tyr Leu Gln Pro Pro
 1               5                  


<210> 176
<211> 9
<212> PRT
<213> Homo sapiens

<400> 176
Lys Ala Asp Pro Tyr Val Val Val Ser
 1               5                  


<210> 177
<211> 9
<212> PRT
<213> Homo sapiens

<400> 177
Thr Lys Glu Arg Tyr Ile Pro Lys Gln
 1               5                  


<210> 178
<211> 9
<212> PRT
<213> Homo sapiens

<400> 178
Glu Val Asp Gly Tyr Asn Ala Trp Arg
 1               5                  


<210> 179
<211> 9
<212> PRT
<213> Homo sapiens

<400> 179
Pro Ala Pro Glu Tyr Arg Ala Gly Ala
 1               5                  


<210> 180
<211> 9
<212> PRT
<213> Homo sapiens

<400> 180
Ser Ser Asp Ile Tyr Val Lys Ser Trp
 1               5                  


<210> 181
<211> 4
<212> PRT
<213> Homo sapiens

<400> 181
Asn Cys Ser Arg
 1              


<210> 182
<211> 4
<212> PRT
<213> Homo sapiens

<400> 182
Asn Phe Thr Glu
 1              


<210> 183
<211> 4
<212> PRT
<213> Homo sapiens

<400> 183
Asn Arg Ser Leu
 1              


<210> 184
<211> 13
<212> PRT
<213> Homo sapiens

<400> 184
Arg Arg Thr Met Thr Arg Pro Ser Glu Gln Ile Asp Asn
 1               5                  10              


<210> 185
<211> 4
<212> PRT
<213> Homo sapiens

<400> 185
Thr Pro Lys Ala
 1              


<210> 186
<211> 4
<212> PRT
<213> Homo sapiens

<400> 186
Thr Glu Gly Ala
 1              


<210> 187
<211> 4
<212> PRT
<213> Homo sapiens

<400> 187
Thr Trp Arg Leu
 1              


<210> 188
<211> 4
<212> PRT
<213> Homo sapiens

<400> 188
Thr Ser Glu Leu
 1              


<210> 189
<211> 4
<212> PRT
<213> Homo sapiens

<400> 189
Thr Ala Pro Leu
 1              


<210> 190
<211> 4
<212> PRT
<213> Homo sapiens

<400> 190
Thr Leu Lys Ile
 1              


<210> 191
<211> 4
<212> PRT
<213> Homo sapiens

<400> 191
Thr Arg Pro Leu
 1              


<210> 192
<211> 8
<212> PRT
<213> Homo sapiens

<400> 192
Phe Gly Pro Ala Trp Val Pro Leu
 1               5              


<210> 193
<211> 4
<212> PRT
<213> Homo sapiens

<400> 193
Asp Glu Asn Leu
 1              


<210> 194
<211> 4
<212> PRT
<213> Homo sapiens

<400> 194
Phe Glu Leu Ile
 1              


<210> 195
<211> 4
<212> PRT
<213> Homo sapiens

<400> 195
Arg Asp Ser Leu
 1              


<210> 196
<211> 4
<212> PRT
<213> Homo sapiens

<400> 196
Asn Glu Gly Val
 1              


<210> 197
<211> 4
<212> PRT
<213> Homo sapiens

<400> 197
Val Glu Glu Leu
 1              


<210> 198
<211> 4
<212> PRT
<213> Homo sapiens

<400> 198
Glu Glu Leu Leu
 1              


<210> 199
<211> 4
<212> PRT
<213> Homo sapiens

<400> 199
Pro Glu Asn Val
 1              


<210> 200
<211> 4
<212> PRT
<213> Homo sapiens

<400> 200
Glu Asp Phe Leu
 1              


<210> 201
<211> 4
<212> PRT
<213> Homo sapiens

<400> 201
Glu Glu Gln Leu
 1              


<210> 202
<211> 4
<212> PRT
<213> Homo sapiens

<400> 202
Glu Glu Glu Leu
 1              


<210> 203
<211> 4
<212> PRT
<213> Homo sapiens

<400> 203
Ala Glu Arg Leu
 1              


<210> 204
<211> 4
<212> PRT
<213> Homo sapiens

<400> 204
Val Glu Arg Leu
 1              


<210> 205
<211> 4
<212> PRT
<213> Homo sapiens

<400> 205
Leu Glu Val Leu
 1              


<210> 206
<211> 4
<212> PRT
<213> Homo sapiens

<400> 206
Pro Asp Val Leu
 1              


<210> 207
<211> 4
<212> PRT
<213> Homo sapiens

<400> 207
Gln Asp Val Leu
 1              


<210> 208
<211> 4
<212> PRT
<213> Homo sapiens

<400> 208
Pro Asp Leu Leu
 1              


<210> 209
<211> 4
<212> PRT
<213> Homo sapiens

<400> 209
Gly Glu Leu Ile
 1              


<210> 210
<211> 4
<212> PRT
<213> Homo sapiens

<400> 210
Val Glu Val Leu
 1              


<210> 211
<211> 4
<212> PRT
<213> Homo sapiens

<400> 211
Ser Glu Val Leu
 1              


<210> 212
<211> 4
<212> PRT
<213> Homo sapiens

<400> 212
Thr Glu Leu Val
 1              


<210> 213
<211> 4
<212> PRT
<213> Homo sapiens

<400> 213
Glu Glu Asp Ile
 1              


<210> 214
<211> 4
<212> PRT
<213> Homo sapiens

<400> 214
Pro Glu Glu Leu
 1              


<210> 215
<211> 4
<212> PRT
<213> Homo sapiens

<400> 215
Ser Asp Gly Val
 1              


<210> 216
<211> 4
<212> PRT
<213> Homo sapiens

<400> 216
Glu Asp Trp Leu
 1              


<210> 217
<211> 4
<212> PRT
<213> Homo sapiens

<400> 217
Ser Glu Ala Val
 1              


<210> 218
<211> 4
<212> PRT
<213> Homo sapiens

<400> 218
Pro Glu Thr Leu
 1              


<210> 219
<211> 4
<212> PRT
<213> Homo sapiens

<400> 219
Pro Glu His Val
 1              


<210> 220
<211> 4
<212> PRT
<213> Homo sapiens

<400> 220
Pro Glu Asp Leu
 1              


<210> 221
<211> 4
<212> PRT
<213> Homo sapiens

<400> 221
Phe Glu Leu Leu
 1              


<210> 222
<211> 4
<212> PRT
<213> Homo sapiens

<400> 222
Pro Glu Pro Leu
 1              


<210> 223
<211> 4
<212> PRT
<213> Homo sapiens

<400> 223
Tyr Gln Pro Pro
 1              


<210> 224
<211> 7
<212> PRT
<213> Homo sapiens

<400> 224
Arg Ala Glu Pro Glu Pro Pro
 1               5          


<210> 225
<211> 7
<212> PRT
<213> Homo sapiens

<400> 225
Arg Leu Glu Pro Ser Val Pro
 1               5          


<210> 226
<211> 7
<212> PRT
<213> Homo sapiens

<400> 226
Leu Pro Pro Pro Met Leu Pro
 1               5          


<210> 227
<211> 7
<212> PRT
<213> Homo sapiens

<400> 227
Pro Met Leu Pro Pro Ala Pro
 1               5          


<210> 228
<211> 7
<212> PRT
<213> Homo sapiens

<400> 228
Arg Ala Glu Pro Glu Pro Pro
 1               5          


<210> 229
<211> 7
<212> PRT
<213> Homo sapiens

<400> 229
Ala Glu Gly Pro Glu Ile Pro
 1               5          


<210> 230
<211> 7
<212> PRT
<213> Homo sapiens

<400> 230
Pro Glu Asn Val Leu Ala Pro
 1               5          


<210> 231
<211> 7
<212> PRT
<213> Homo sapiens

<400> 231
Ala Glu Glu Pro Gln Pro Pro
 1               5          


<210> 232
<211> 7
<212> PRT
<213> Homo sapiens

<400> 232
Glu Pro Gln Pro Pro Leu Pro
 1               5          


<210> 233
<211> 7
<212> PRT
<213> Homo sapiens

<400> 233
Arg Leu Glu Pro Ser Val Pro
 1               5          


<210> 234
<211> 7
<212> PRT
<213> Homo sapiens

<400> 234
Leu Leu Glu Val Glu Gln Pro
 1               5          


<210> 235
<211> 7
<212> PRT
<213> Homo sapiens

<400> 235
Gln Asp Leu Pro Glu Gln Pro
 1               5          


<210> 236
<211> 7
<212> PRT
<213> Homo sapiens

<400> 236
Asp Met Met Pro Lys Gly Pro
 1               5          


<210> 237
<211> 7
<212> PRT
<213> Homo sapiens

<400> 237
Leu Tyr His Pro His Ser Pro
 1               5          


<210> 238
<211> 7
<212> PRT
<213> Homo sapiens

<400> 238
Pro Gln Asp Val Pro Ala Pro
 1               5          


<210> 239
<211> 7
<212> PRT
<213> Homo sapiens

<400> 239
Gln Asp Val Pro Ala Pro Pro
 1               5          


<210> 240
<211> 7
<212> PRT
<213> Homo sapiens

<400> 240
Asp Ile Lys Pro Arg Gln Pro
 1               5          


<210> 241
<211> 7
<212> PRT
<213> Homo sapiens

<400> 241
Leu Glu Lys Pro Ser Arg Pro
 1               5          


<210> 242
<211> 8
<212> PRT
<213> Homo sapiens

<400> 242
Lys Pro Pro Leu Lys Lys Leu Pro
 1               5              


<210> 243
<211> 4
<212> PRT
<213> Homo sapiens

<400> 243
Pro Glu Glu Glu
 1              


<210> 244
<211> 4
<212> PRT
<213> Homo sapiens

<400> 244
Pro Pro Glu Glu
 1              


<210> 245
<211> 4
<212> PRT
<213> Homo sapiens

<400> 245
Pro Glu Glu Glu
 1              


<210> 246
<211> 4
<212> PRT
<213> Homo sapiens

<400> 246
Ser Leu Gln Glu
 1              


<210> 247
<211> 4
<212> PRT
<213> Homo sapiens

<400> 247
Thr Val Glu Glu
 1              


<210> 248
<211> 9
<212> PRT
<213> Homo sapiens

<400> 248
Gly Val Pro Ala Glu Arg Pro Trp Ala
 1               5                  


<210> 249
<211> 9
<212> PRT
<213> Homo sapiens

<400> 249
Ala Arg Pro Glu Glu Glu Lys Glu Glu
 1               5                  


<210> 250
<211> 9
<212> PRT
<213> Homo sapiens

<400> 250
Asp Pro Pro Glu Glu Glu Gly Glu Met
 1               5                  


<210> 251
<211> 9
<212> PRT
<213> Homo sapiens

<400> 251
Pro Asp Pro Glu Glu Leu Asp Trp Gly
 1               5                  


<210> 252
<211> 4
<212> PRT
<213> Homo sapiens

<400> 252
Pro Pro Leu Pro
 1              


<210> 253
<211> 7
<212> PRT
<213> Homo sapiens

<400> 253
Gly Ala Thr Gly Ala Trp Ser
 1               5          


<210> 254
<211> 7
<212> PRT
<213> Homo sapiens

<400> 254
Met Phe Ser Pro Leu Lys Ser
 1               5          


<210> 255
<211> 7
<212> PRT
<213> Homo sapiens

<400> 255
Arg Asp Thr Arg Ala Gly Thr
 1               5          


<210> 256
<211> 7
<212> PRT
<213> Homo sapiens

<400> 256
Val Ala Ser Gln Pro Ile Ser
 1               5          


<210> 257
<211> 7
<212> PRT
<213> Homo sapiens

<400> 257
Pro Ile Ser Phe Glu Ile Ser
 1               5          


<210> 258
<211> 7
<212> PRT
<213> Homo sapiens

<400> 258
Ile Gln Ser Leu Met Leu Thr
 1               5          


<210> 259
<211> 7
<212> PRT
<213> Homo sapiens

<400> 259
Pro His Ser Gly Arg Leu Ser
 1               5          


<210> 260
<211> 7
<212> PRT
<213> Homo sapiens

<400> 260
Leu Ala Ser Tyr Arg Glu Ser
 1               5          


<210> 261
<211> 7
<212> PRT
<213> Homo sapiens

<400> 261
Arg Glu Ser Pro Asn Phe Thr
 1               5          


<210> 262
<211> 7
<212> PRT
<213> Homo sapiens

<400> 262
Phe Leu Thr Pro Pro Glu Thr
 1               5          


<210> 263
<211> 7
<212> PRT
<213> Homo sapiens

<400> 263
Pro Gly Ser Ser Ser Pro Thr
 1               5          


<210> 264
<211> 7
<212> PRT
<213> Homo sapiens

<400> 264
Lys Pro Ser Arg Pro Lys Thr
 1               5          


<210> 265
<211> 4
<212> PRT
<213> Homo sapiens

<400> 265
Glu Ala Thr Met
 1              


<210> 266
<211> 4
<212> PRT
<213> Homo sapiens

<400> 266
Asp Pro Thr Val
 1              


<210> 267
<211> 4
<212> PRT
<213> Homo sapiens

<400> 267
Glu Ile Ser Ile
 1              


<210> 268
<211> 4
<212> PRT
<213> Homo sapiens

<400> 268
Asp His Thr Trp
 1              


<210> 269
<211> 4
<212> PRT
<213> Homo sapiens

<400> 269
Glu Pro Ser Ala
 1              


<210> 270
<211> 4
<212> PRT
<213> Homo sapiens

<400> 270
Glu Pro Ser Val
 1              


<210> 271
<211> 7
<212> PRT
<213> Homo sapiens

<400> 271
Leu Gln Val Ser Pro Ile Gln
 1               5          


<210> 272
<211> 7
<212> PRT
<213> Homo sapiens

<400> 272
Val Met Phe Ser Pro Leu Lys
 1               5          


<210> 273
<211> 7
<212> PRT
<213> Homo sapiens

<400> 273
Leu Tyr Gly Ser Pro Pro Gly
 1               5          


<210> 274
<211> 7
<212> PRT
<213> Homo sapiens

<400> 274
Arg Asp Gln Thr Pro Lys Ala
 1               5          


<210> 275
<211> 7
<212> PRT
<213> Homo sapiens

<400> 275
Leu Asp Ala Ser Pro Gly Ala
 1               5          


<210> 276
<211> 7
<212> PRT
<213> Homo sapiens

<400> 276
Tyr Arg Glu Ser Pro Asn Phe
 1               5          


<210> 277
<211> 7
<212> PRT
<213> Homo sapiens

<400> 277
Gly Thr Val Ser Pro Lys Lys
 1               5          


<210> 278
<211> 7
<212> PRT
<213> Homo sapiens

<400> 278
Val Phe Leu Thr Pro Pro Glu
 1               5          


<210> 279
<211> 7
<212> PRT
<213> Homo sapiens

<400> 279
Gly Ser Ser Ser Pro Thr Val
 1               5          


<210> 280
<211> 7
<212> PRT
<213> Homo sapiens

<400> 280
His Pro His Ser Pro Gly Leu
 1               5          


<210> 281
<211> 328
<212> PRT
<213> Homo sapiens

<400> 281
Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val
 1               5                  10                  15      
Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile
            20                  25                  30          
Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly
        35                  40                  45              
Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu
    50                  55                  60                  
His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu
65                  70                  75                  80  
Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr
                85                  90                  95      
Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu
            100                 105                 110         
Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp
        115                 120                 125             
Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln
    130                 135                 140                 
Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val
145                 150                 155                 160 
Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys
                165                 170                 175     
Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu
            180                 185                 190         
Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg
        195                 200                 205             
Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp
    210                 215                 220                 
Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe
225                 230                 235                 240 
Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly
                245                 250                 255     
Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser
            260                 265                 270         
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
        275                 280                 285             
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
    290                 295                 300                 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
305                 310                 315                 320 
Val Ile Phe Arg Pro Leu His Lys
                325             


<210> 282
<211> 236
<212> PRT
<213> Homo sapiens

<400> 282
Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val
 1               5                  10                  15      
Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser
            20                  25                  30          
Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu
        35                  40                  45              
Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr
    50                  55                  60                  
Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly
65                  70                  75                  80  
His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser
                85                  90                  95      
Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln
            100                 105                 110         
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr
        115                 120                 125             
Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val
    130                 135                 140                 
Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro
145                 150                 155                 160 
Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser
                165                 170                 175     
Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu
            180                 185                 190         
Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn
        195                 200                 205             
Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr
    210                 215                 220                 
Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
225                 230                 235     


<210> 283
<211> 17
<212> PRT
<213> Homo sapiens

<400> 283
Pro Thr Glu Arg Glu Val Ser Val Arg Arg Arg Ser Gly Pro Phe Ala
 1               5                  10                  15      
Leu
    


<210> 284
<211> 19
<212> PRT
<213> Homo sapiens

<400> 284
Leu Pro Thr Glu Arg Glu Val Ser Val Arg Arg Arg Ser Gly Pro Phe
 1               5                  10                  15      
Ala Leu Glu
            


<210> 285
<211> 29
<212> PRT
<213> Homo sapiens

<400> 285
Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Arg Arg
 1               5                  10                  15      
Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg
            20                  25                  


<210> 286
<211> 17
<212> PRT
<213> Homo sapiens

<400> 286
Leu Pro Thr Glu Arg Glu Val Ser Ile Trp Arg Arg Ser Gly Pro Phe
 1               5                  10                  15      
Ala
    


<210> 287
<211> 19
<212> PRT
<213> Homo sapiens

<400> 287
Tyr Leu Pro Thr Glu Arg Glu Val Ser Ile Trp Arg Arg Ser Gly Pro
 1               5                  10                  15      
Phe Ala Leu
            


<210> 288
<211> 29
<212> PRT
<213> Homo sapiens

<400> 288
Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Ile Trp
 1               5                  10                  15      
Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
            20                  25                  


<210> 289
<211> 57
<212> PRT
<213> Homo sapiens

<400> 289
Leu Val Leu Gln Val Trp Asp Tyr Thr Ala Ser Leu Pro Met Thr Ser
 1               5                  10                  15      
Leu Asp Pro Trp Ser Cys Ser Tyr Gln Thr Trp Cys Val Gly Pro Gly
            20                  25                  30          
Ala Pro Ser Ser Ala Leu Cys Ser Trp Pro Ala Met Gly Pro Gly Arg
        35                  40                  45              
Gly Ala Ile Cys Phe Ala Ala Ala Ala
    50                  55          


<210> 290
<211> 58
<212> PRT
<213> Homo sapiens

<400> 290
Val Leu Val Leu Gln Val Trp Asp Tyr Thr Ala Ser Leu Pro Met Thr
 1               5                  10                  15      
Ser Leu Asp Pro Trp Ser Cys Ser Tyr Gln Thr Trp Cys Val Gly Pro
            20                  25                  30          
Gly Ala Pro Ser Ser Ala Leu Cys Ser Trp Pro Ala Met Gly Pro Gly
        35                  40                  45              
Arg Gly Ala Ile Cys Phe Ala Ala Ala Ala
    50                  55              


<210> 291
<211> 63
<212> PRT
<213> Homo sapiens

<400> 291
Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Thr Ala
 1               5                  10                  15      
Ser Leu Pro Met Thr Ser Leu Asp Pro Trp Ser Cys Ser Tyr Gln Thr
            20                  25                  30          
Trp Cys Val Gly Pro Gly Ala Pro Ser Ser Ala Leu Cys Ser Trp Pro
        35                  40                  45              
Ala Met Gly Pro Gly Arg Gly Ala Ile Cys Phe Ala Ala Ala Ala
    50                  55                  60              


<210> 292
<211> 17
<212> PRT
<213> Homo sapiens

<400> 292
Met Ser Ser Asp Ile Tyr Val Lys Arg Trp Val Lys Gly Leu Glu His
 1               5                  10                  15      
Asp
    


<210> 293
<211> 19
<212> PRT
<213> Homo sapiens

<400> 293
Glu Met Ser Ser Asp Ile Tyr Val Lys Arg Trp Val Lys Gly Leu Glu
 1               5                  10                  15      
His Asp Lys
            


<210> 294
<211> 29
<212> PRT
<213> Homo sapiens

<400> 294
Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Arg Trp
 1               5                  10                  15      
Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val
            20                  25                  


<210> 295
<211> 17
<212> PRT
<213> Homo sapiens

<400> 295
Phe Asn Trp Phe Val Asn Pro Leu Asn Thr Phe Val Phe Phe Ile Trp
 1               5                  10                  15      
Arg
    


<210> 296
<211> 19
<212> PRT
<213> Homo sapiens

<400> 296
Ser Phe Asn Trp Phe Val Asn Pro Leu Asn Thr Phe Val Phe Phe Ile
 1               5                  10                  15      
Trp Arg Arg
            


<210> 297
<211> 29
<212> PRT
<213> Homo sapiens

<400> 297
Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Asn Thr
 1               5                  10                  15      
Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu
            20                  25                  


<210> 298
<211> 17
<212> PRT
<213> Homo sapiens

<400> 298
Asn Trp Phe Val Asn Pro Leu Lys Ala Phe Val Phe Phe Ile Trp Arg
 1               5                  10                  15      
Arg
    


<210> 299
<211> 19
<212> PRT
<213> Homo sapiens

<400> 299
Phe Asn Trp Phe Val Asn Pro Leu Lys Ala Phe Val Phe Phe Ile Trp
 1               5                  10                  15      
Arg Arg Tyr
            


<210> 300
<211> 29
<212> PRT
<213> Homo sapiens

<400> 300
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Ala Phe
 1               5                  10                  15      
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val
            20                  25                  


<210> 301
<211> 16
<212> PRT
<213> Homo sapiens

<400> 301
Asn Trp Phe Val Asn Pro Leu Asn Ala Phe Val Phe Phe Ile Trp Arg
 1               5                  10                  15      


<210> 302
<211> 18
<212> PRT
<213> Homo sapiens

<400> 302
Phe Asn Trp Phe Val Asn Pro Leu Asn Ala Phe Val Phe Phe Ile Trp
 1               5                  10                  15      
Arg Arg
        


<210> 303
<211> 28
<212> PRT
<213> Homo sapiens

<400> 303
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Asn Ala Phe
 1               5                  10                  15      
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu
            20                  25              


<210> 304
<211> 16
<212> PRT
<213> Homo sapiens

<400> 304
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
 1               5                  10                  15      


<210> 305
<211> 17
<212> PRT
<213> Homo sapiens

<400> 305
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
 1               5                  10                  15      
Gln
    


<210> 306
<211> 28
<212> PRT
<213> Homo sapiens

<400> 306
Glu Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Asp Leu
 1               5                  10                  15      
Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu Ser Ile
            20                  25              


<210> 307
<211> 18
<212> PRT
<213> Homo sapiens

<400> 307
Met Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly
 1               5                  10                  15      
Arg Ile
        


<210> 308
<211> 19
<212> PRT
<213> Homo sapiens

<400> 308
Ser Met Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu
 1               5                  10                  15      
Gly Arg Ile
            


<210> 309
<211> 24
<212> PRT
<213> Homo sapiens

<400> 309
Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp Gln Asp Leu
 1               5                  10                  15      
Gln Gln Val Pro Glu Gly Arg Ile
            20                  


<210> 310
<211> 16
<212> PRT
<213> Homo sapiens

<400> 310
Lys Leu Arg Phe Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met
 1               5                  10                  15      


<210> 311
<211> 17
<212> PRT
<213> Homo sapiens

<400> 311
Ala Lys Leu Arg Phe Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu
 1               5                  10                  15      
Met
    


<210> 312
<211> 28
<212> PRT
<213> Homo sapiens

<400> 312
Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe Leu Ala Glu Glu His Asn
 1               5                  10                  15      
Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser
            20                  25              


<210> 313
<211> 34
<212> PRT
<213> Homo sapiens

<400> 313
Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile Gln
 1               5                  10                  15      
Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala Pro
            20                  25                  30          
Ala Asp
        


<210> 314
<211> 36
<212> PRT
<213> Homo sapiens

<400> 314
Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile
 1               5                  10                  15      
Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala
            20                  25                  30          
Pro Ala Asp Pro
        35      


<210> 315
<211> 46
<212> PRT
<213> Homo sapiens

<400> 315
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg
 1               5                  10                  15      
Asn Leu Cys Lys Ile Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala
            20                  25                  30          
Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp
        35                  40                  45      


<210> 316
<211> 18
<212> PRT
<213> Homo sapiens

<400> 316
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
 1               5                  10                  15      
Pro Phe
        


<210> 317
<211> 19
<212> PRT
<213> Homo sapiens

<400> 317
Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln
 1               5                  10                  15      
Glu Pro Phe
            


<210> 318
<211> 24
<212> PRT
<213> Homo sapiens

<400> 318
His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp Val
 1               5                  10                  15      
Gln Gln Gly Pro Gln Glu Pro Phe
            20                  


<210> 319
<211> 28
<212> PRT
<213> Homo sapiens

<400> 319
Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu Pro Pro Val Ala
 1               5                  10                  15      
Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
            20                  25              


<210> 320
<211> 28
<212> PRT
<213> Homo sapiens

<400> 320
Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu Pro Pro Val Ala
 1               5                  10                  15      
Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
            20                  25              


<210> 321
<211> 28
<212> PRT
<213> Homo sapiens

<400> 321
Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu Pro Pro Val Ala
 1               5                  10                  15      
Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
            20                  25              


<210> 322
<211> 16
<212> PRT
<213> Homo sapiens

<400> 322
Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu
 1               5                  10                  15      


<210> 323
<211> 18
<212> PRT
<213> Homo sapiens

<400> 323
Val Val Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe
 1               5                  10                  15      
Glu Leu
        


<210> 324
<211> 28
<212> PRT
<213> Homo sapiens

<400> 324
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Gly Lys
 1               5                  10                  15      
Val Glu Ala Glu Phe Glu Leu Leu Thr Val Glu Glu
            20                  25              


<210> 325
<211> 2036
<212> PRT
<213> Homo sapiens

<400> 325
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu Glu
    1650                1655                1660                
Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe
1665                1670                1675                1680
Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His
                1685                1690                1695    
Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp
            1700                1705                1710        
Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro
        1715                1720                1725            
Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu
    1730                1735                1740                
Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser
1745                1750                1755                1760
Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln
                1765                1770                1775    
Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn
            1780                1785                1790        
Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val
        1795                1800                1805            
Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
    1810                1815                1820                
Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile
1825                1830                1835                1840
Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met
                1845                1850                1855    
Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg
            1860                1865                1870        
Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg
        1875                1880                1885            
Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg
    1890                1895                1900                
Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg
1905                1910                1915                1920
Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn
                1925                1930                1935    
Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr
            1940                1945                1950        
Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro
        1955                1960                1965            
Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe
    1970                1975                1980                
Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp
1985                1990                1995                2000
Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu
                2005                2010                2015    
Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg
            2020                2025                2030        
Pro Leu His Lys
        2035    


<210> 326
<211> 81
<212> PRT
<213> Homo sapiens

<400> 326
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro
    


<210> 327
<211> 82
<212> PRT
<213> Homo sapiens

<400> 327
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu
        


<210> 328
<211> 87
<212> PRT
<213> Homo sapiens

<400> 328
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu Trp Asp Glu Leu Leu
                85          


<210> 329
<211> 16
<212> PRT
<213> Homo sapiens

<400> 329
Gly Ile Ser Arg Gln Leu Leu Lys His Asn Phe Asp Glu Asp Glu Met
 1               5                  10                  15      


<210> 330
<211> 18
<212> PRT
<213> Homo sapiens

<400> 330
Ala Gly Ile Ser Arg Gln Leu Leu Lys His Asn Phe Asp Glu Asp Glu
 1               5                  10                  15      
Met Asp
        


<210> 331
<211> 28
<212> PRT
<213> Homo sapiens

<400> 331
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His Asn
 1               5                  10                  15      
Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser
            20                  25              


<210> 332
<211> 18
<212> PRT
<213> Homo sapiens

<400> 332
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
 1               5                  10                  15      
Pro Phe
        


<210> 333
<211> 19
<212> PRT
<213> Homo sapiens

<400> 333
Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln
 1               5                  10                  15      
Glu Pro Phe
            


<210> 334
<211> 24
<212> PRT
<213> Homo sapiens

<400> 334
His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp Val
 1               5                  10                  15      
Gln Gln Gly Pro Gln Glu Pro Phe
            20                  


<210> 335
<211> 2918
<212> DNA
<213> Homo sapiens

<400> 335
atcaaggccc tgggctggag gaagacatcc cagatccaga ggagctcgac tgggggtcca 60
agtactatgc gtcgctgcag gagctccagg ggcagcacaa ctttgatgaa gatgaaatgg 120
atgatcctgg agattcagat ggggtcaacc tcatttctat ggttggggag atccaagacc 180
agggtgaggc tgaagtcaaa ggcactgtgt ccccaaaaaa agcagttgcc accctgaaga 240
tctacaacag gtccctggag gaagaattta accactttga agactggctg aatgtgtttc 300
ctctgtaccg agggcaaggg ggccaggatg gaggtggaga agaggaagga tctggacacc 360
ttgtgggcaa gttcaagggc tccttcctca tttaccctga atcagaggca gtgttgttct 420
ctgagcccca gatctctcgg gggatcccac agaaccggcc catcaagctc ctggtcagag 480
tgtatgttgt aaaggctacc aacctggctc ctgcagaccc caatggcaaa gcagaccctt 540
acgtggtggt gagcgctggc cgggagcggc aggacaccaa ggaacgctac atccccaagc 600
agctcaaccc catctttgga gagatcctgg agctaagcat ctctctccca gctgagacgg 660
agctgacggt cgccgtattt gaacatgacc tcgtgggttc tgacgacctc atcggggaga 720
cccacattga tctggaaaac cgattctata gccaccacag agcaaactgt gggctggcct 780
cccagtatga agtgtgggtc cagcagggcc cacaggagcc attctgagtt tctggccaaa 840
cacattcaag ctcacattcc cttttgtgtc tccagatcct atgatttcat ggaaggggac 900
cctcccaccc accgccactg ccaaccaaga catagctcag tggtcaagac ttgggcttgg 960
gagtcgggat cctgtaacga atgtcacttg accgctttct ttttttatga aacagtctcg 1020
ctctgtctcc caggttggag tgcagtggca cgatctcggc tgactgcaac ctccacctcc 1080
tgggttcaag cgattctcct gcctcagcct ccccagtagc tgggattaca ggcgtgggcc 1140
cccatgtcca gctaattttt atattttcgc tctgtctccc aggttggagt gcagtggcac 1200
gatctcggct gactgcaacc tccacctcct gggttcaagc gattctcctg cctcagcctc 1260
cccagtagct gggattacag gcgtgggccc ccatgtccag ctaattttta tatttttagt 1320
agagacaggg tttcaccatg ttgtccaggc tggtcttgaa cccctgacct caagtgatcc 1380
acccacctct gcctcccaaa gtgctgggat tacaggtgtg agccaccatg ccaggccctc 1440
ttaacctctt caagtctgtt ttctcatctg caaaacagag gtaataagat cagtatcttc 1500
ttaatggaag cacctgggct acattttttt cattcattgt tatcataaat gaggactaac 1560
ctgtctcccg ttgggagttt tgaacctaga cctcatgtct tcatgacgtc atcactgccc 1620
caggcccagc tgtgtcccta caccagcccc agctgacgca tcttcttttt ctgcctgtag 1680
agatggttac aatgcctggc gtgatgcatt ctggccttcg cagatcctgg cggggctgtg 1740
ccaacgctgt ggcctccctg cccctgaata ccgagccggt gctgtcaagg tgggcagcaa 1800
agtcttcctg acaccaccgg agaccctgcc cccagggatc tcttcacatg tggattgaca 1860
tctttcctca agatgtgcct gctccacccc cagttgacat caagcctcgg cagccaatca 1920
gctatgagct cagagttgtc atctggaaca cggaggatgt ggttctggat gacgagaatc 1980
cactcaccgg agagatgtcg agtgacatct atgtgaagag ctgggtgaag gggttggagc 2040
atgacaagca ggagacagac gttcacttca actccctgac tggggagggg aacttcaatt 2100
ggcgctttgt gttccgcttt gactacctgc ccacggagcg ggaggtgagc gtctggcgca 2160
ggtctggacc ctttgccctg gaggaggcgg agttccggca gcctgcagtg ctggtcctgc 2220
aggatccctg gagttgcagc taccagacat ggtgcgtggg gcccggggcc ccgagctctg 2280
ctctgtgcag ctggcccgca atggggccgg gccgaggtgc aatctgtttc gctgccgccg 2340
cctgaggggc tggtggccgg tagtgaagct gaaggaggca gaggacgtgg agcgggaggc 2400
gcaggaggct caggctggca agaagaagcg aaagcagagg aggaggaagg gccggccaga 2460
agacctggag ttcacagaca tgggtggcaa tgtgtacatc ctcacgggca aggtggaggc 2520
agagtttgag ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa 2580
gcagccagag cctctggaga aacccagccg ccccaaaact tccttcaact ggtttgtgaa 2640
cccgctgaag acctttgtct tcttcatctg gcgccggtac tggcgcaccc tggtgctgct 2700
gctactggtg ctgctcaccg tcttcctcct cctggtcttc tacaccatcc ctggccagat 2760
cagccaggtc atcttccgtc ccctccacaa gtgactctcg ctgaccttgg acactcaccc 2820
agggtgccaa cccttcaatg cctgctcctg gaagtctttc ttacccatgt gagctacccc 2880
agagtctagt gcttcctctg aataaaccta tcacagcc                         2918

<210> 336
<211> 1954
<212> DNA
<213> Homo sapiens

<400> 336
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgc tgggtgaagg ggttggagca tgacaagcag gagacagacg 1080
ttcacttcaa ctccctgavc tggggagggg aacttcaatt ggcgctttgt gttccgcttt 1140
gactacctgc ccacggagcv gggaggtgag cgtctggcgc aggtctggac cctttgccct 1200
ggaggaggcg gagttccggc vagcctgcag tgctggtcct gcaggvggat ccctggagtt 1260
gcagctacca gacatggtgc gtggggcccg gggccccgag ctctgcvtct gtgcagctgg 1320
cccgcaatgg ggccgggccg aggtgcaatc tgtttcgctg ccgccgcvct gaggggctgg 1380
tggccggtag tgaagctgaa ggaggcagag gacgtggagc gggaggcgvc aggaggctca 1440
ggctggcaag aagaagcgaa agcagaggag gaggaagggc cggccagaav gacctggagt 1500
tcacagacat gggtggcaat gtgtacatcc tcacgggcaa ggtggaggca vgagtttgag 1560
ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa gvcagccaga 1620
gcctctggag aaacccagcc gccccaaaac ttccttcaac tggtttgtga acvccgctga 1680
agacctttgt cttcttcatc tggcgccggt actggcgcac cctggtgctg ctgvctactg 1740
gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca gatcvagcca 1800
ggtcatcttc cgtcccctcc acaagtgact ctcgctgacc ttggacactc acccavgggt 1860
gccaaccctt caatgcctgc tcctggaagt ctttcttacc catgtgagct accccavgag 1920
tctagtgctt cctctgaata aacctatcac agcc                             1954

<210> 337
<211> 1954
<212> DNA
<213> Homo sapiens

<400> 337
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctgggct acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgc tgggtgaagg ggttggagca tgacaagcag gagacagacg 1080
ttcacttcaa ctccctgavc tggggagggg aacttcaatt ggcgctttgt gttccgcttt 1140
gactacctgc ccacggagcv gggaggtgag cgtctggcgc aggtctggac cctttgccct 1200
ggaggaggcg gagttccggc vagcctgcag tgctggtcct gcaggvggat ccctggagtt 1260
gcagctacca gacatggtgc gtggggcccg gggccccgag ctctgcvtct gtgcagctgg 1320
cccgcaatgg ggccgggccg aggtgcaatc tgtttcgctg ccgccgcvct gaggggctgg 1380
tggccggtag tgaagctgaa ggaggcagag gacgtggagc gggaggcgvc aggaggctca 1440
ggctggcaag aagaagcgaa agcagaggag gaggaagggc cggccagaav gacctggagt 1500
tcacagacat gggtggcaat gtgtacatcc tcacgggcaa ggtggaggca vgagtttgag 1560
ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa gvcagccaga 1620
gcctctggag aaacccagcc gccccaaaac ttccttcaac tggtttgtga acvccgctga 1680
agacctttgt cttcttcatc tggcgccggt actggcgcac cctggtgctg ctgvctactg 1740
gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca gatcvagcca 1800
ggtcatcttc cgtcccctcc acaagtgact ctcgctgacc ttggacactc acccavgggt 1860
gccaaccctt caatgcctgc tcctggaagt ctttcttacc catgtgagct accccavgag 1920
tctagtgctt cctctgaata aacctatcac agcc                             1954

<210> 338
<211> 236
<212> PRT
<213> Homo sapiens

<400> 338
Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val
 1               5                  10                  15      
Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser
            20                  25                  30          
Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Glu
        35                  40                  45              
Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr
    50                  55                  60                  
Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly
65                  70                  75                  80  
His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser
                85                  90                  95      
Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln
            100                 105                 110         
Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr
        115                 120                 125             
Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val
    130                 135                 140                 
Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro
145                 150                 155                 160 
Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser
                165                 170                 175     
Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Glu His Asp Leu
            180                 185                 190         
Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn
        195                 200                 205             
Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr
    210                 215                 220                 
Glu Val Trp Val Gln Gln Gly Pro Gln Glu Pro Phe
225                 230                 235     


<210> 339
<211> 181
<212> PRT
<213> Homo sapiens

<400> 339
Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala
 1               5                  10                  15      
Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu
            20                  25                  30          
Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu
        35                  40                  45              
Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg
    50                  55                  60                  
Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly
65                  70                  75                  80  
Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu
                85                  90                  95      
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
            100                 105                 110         
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
        115                 120                 125             
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
    130                 135                 140                 
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu
145                 150                 155                 160 
Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe
                165                 170                 175     
Arg Pro Leu His Lys
            180     


<210> 340
<211> 185
<212> PRT
<213> Homo sapiens

<400> 340
Val Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu
 1               5                  10                  15      
Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg
            20                  25                  30          
Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val
        35                  40                  45              
Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Val Arg Lys
    50                  55                  60                  
Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met
65                  70                  75                  80  
Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu
                85                  90                  95      
Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg
            100                 105                 110         
Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Val Arg Pro Lys Thr Ser
        115                 120                 125             
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
    130                 135                 140                 
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
145                 150                 155                 160 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
                165                 170                 175     
Val Ile Phe Arg Pro Leu His Val Lys
            180                 185 


<210> 341
<211> 185
<212> PRT
<213> Homo sapiens

<400> 341
Val Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu
 1               5                  10                  15      
Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg
            20                  25                  30          
Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val
        35                  40                  45              
Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Val Arg Lys
    50                  55                  60                  
Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met
65                  70                  75                  80  
Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu
                85                  90                  95      
Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg
            100                 105                 110         
Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Val Arg Pro Lys Thr Ser
        115                 120                 125             
Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp
    130                 135                 140                 
Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr
145                 150                 155                 160 
Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln
                165                 170                 175     
Val Ile Phe Arg Pro Leu His Val Lys
            180                 185 


<210> 342
<211> 7108
<212> DNA
<213> Homo sapiens

<400> 342
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gaccatggct ctgacggtaa gcgtgcaacg actaacaggg ctgaccggca cccacgaccg 120
acaagtgaag ctcacctttc gaggctttac ccagaaaaca agaaaaattc actgtggtcc 180
agaagcagat atcggtgagc tgttccgatg gccccactat ggggctccac tggctgggga 240
gtgtctgtct gtgcaggtgg tcaactgcag ccgtgtattc agccttaggc ctctagggac 300
cctggtgatc tccctgcagc agctacagaa tgctgggcat ttggtgctac gggaagccct 360
agtggatgag aatcttcaag tgtccccgat ccaggtggag cttgacctga agtaccagcc 420
cccagagggc gctactggag cctggtcaga ggaggacttt ggggcaccca tccaggacag 480
cttcgagtta atcatcccca atgtgggctt ccaggaactg gagcctgggg aggcccagct 540
ggagcggcgg gcagtggctc taggccgcag gctagctcga agtctaggcc agcaggacga 600
tgaagagaat gagctggagc ttgagctgga gcaggacctg gatgatgagc ctgacgtgga 660
actttctggt gttatgttca gccccctcaa gagccgcgcc agggccctgg cccatgggga 720
tcccttccag gtgtccagag ctcaagactt ccaggtggga gtcactgtgc tggaagccca 780
gaaactggtg ggagtcaaca ttaaccccta tgtggccgtg caagtggggg ggcagcgccg 840
tgtgaccgcc acacagcgtg ggaccagttg ccccttctac aatgagtact tcttgttcga 900
atttcatgac acgcggcttc gtctccaaga cttgctgctg gagatcacgg tgagtggggt 960
aggggtgacc agtgtccttc agagaagggg ggatgagaaa gctgcaggac taacaccacc 1020
ttcccccaag gctttccatt cgcagaccct cccctttatg gccacccgga taggcacctt 1080
caggatggac ctgggcatca tcttggacca gccagatggc cagttctacc aaagatgggt 1140
tccgctgcat gatccccgag acacccgcgc cgggaccaag ggtttcatta aggtcacctt 1200
gtccgtgagg gcgcgcgggg acctgccccc tccaatgcta cccccggccc cagggcactg 1260
ttcggacatc gagaagaacc tgctcctgcc gcgcggggtg cccgccgaga ggccatgggc 1320
gcggctccgc gtgcgcctgt accgcgccga ggggcttccc gcgctgcgcc tggggctgct 1380
gggcagcctg gtccgcgccc tgcacgacca gcgcgtcctg gtggagccct atgtgcgggt 1440
gtctttcctg gggcaggagg gcgagacgtc ggtgagcgcc gaggcggcgg cgcccgaatg 1500
gaacgagcag ctgagcttcg tggagctctt cccgccgctg acgcgcagcc tccgcctgca 1560
gctgcgggac gacgcgcccc tggtcgacgc ggcactcgct acgcacgtgc cggacctgag 1620
gcggatctcc catccgggcc gcgcggcggg gtttaaccct accttcggcc cggcctgggt 1680
gcccctctat ggctcgcccc ccggcgcggg gctccgggat agtcttcaag gtctcaacga 1740
aggcgttggc caaggcattt ggttccgcgg ccgccttctg ctggctgtgt ccatgcaggt 1800
gttggaaggg agagctgaac ctgagcctcc ccaggcccag caggggtcca cgttgtcccg 1860
gctcacccga aagaagaaaa agaaagccag aagggatcag accccaaagg cggttccgca 1920
gcacttggac gccagccccg gtgccgaggg gcctgagatc ccccgtgcca tggaggtgga 1980
ggtggaggag ctgctgccgc tgccagagaa tgtcctggcg ccctgtgaag atttcctgct 2040
tttcggtgtg ctcttcgagg ccaccatgat cgaccccacc gtggcctccc agcccatcag 2100
cttcgagatc tccattggtc gcgcaggccg tctggaggag caattgggcc gagggtccag 2160
ggctggggag ggaactgagg gtgcagccgt ggaggctcag cctctgctgg gagccaggcc 2220
agaggaggag aaagaggagg aagaactggg gacccatgct cagcggcctg agcccatgga 2280
cggcagtggg ccatacttct gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg 2340
gagttgctgg gaggaccaca cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc 2400
cgagaggctg gaccaggggc tgcaggaggt tgagagactg cagcgcaagc cggggcctgg 2460
cgcctgtgca cagctcaagc aggcactgga agtactggtg gctgggagca gacagttttg 2520
ccacggtgcc gagcgcagga cgatgacccg gcccaatgcc ctggatcgat gccgagggaa 2580
actcctggtg cacagcctga accttttggc taagcaagga ctgcgacttc tacgcggcct 2640
gagacggcgc aatgtgcaaa agaaggtggc actggccaag aagctcctgg caaaactgcg 2700
ctttctggct gaggagcccc agccacccct ccccgatgtg ctggtctgga tgctcagcgg 2760
gcagcgccgt gtggcctggg cccggatccc tgcccaggat gtgctgttct ctgtggttga 2820
ggaggaacgg ggccgagact gtgggaagat ccagagtcta atgctcacgg cacccggggc 2880
agcccctggt gaggtctgtg ccaagctgga gctcttcctg cggctgggcc tgggcaagca 2940
agccaaggcc tgcacctctg agctgccccc ggatttgctg cccgagccct cagccgggct 3000
gccctccagc ctacaccggg acgactttag ctacttccaa ctccgggctc acttgtacca 3060
ggcccggggt gtgttggctg cagatgacag tggcctctcg gacccctttg ctcgagtcct 3120
catctctacc cagtgtcaga ccacacgggt cctggagcag acgctgagcc ctctgtggga 3180
tgaactcctg gtatttgagc agttgatcgt ggatgggagg agggagcacc tgcaggagga 3240
gcctccatta gtgatcatca atgtatttga ccacaataag tttggccccc ccgtgttcct 3300
gggcagggca ctggccgccc caagggtaaa gctgatggag gacccatacc aacgcccaga 3360
gttgcagttc ttccccctga ggaagggacc ctgggcagcc ggagagctca ttgccgcctt 3420
tcaactcatt gaactagact acagtggccg acttgagccc tcagtgccca gtgaggtgga 3480
gccccaggat ctggcacccc tggttgagcc ccactctgga cgcctgtccc ttccacccaa 3540
cgtgtgccca gtgctcaggg agttccgtgt tgaggtgctg ttctggggtc ttaggggact 3600
tggtcgtgtg catctgctcg aggtggagca gccccaggtt gtactggagg tggctgggca 3660
aggtgtggag tctgaggtcc tggccagcta ccgtgagagc cccaatttca ctgagcttgt 3720
caggcatctg acagtggact tgccggagca gccttacttg cagcctccac tcagcatctt 3780
ggtgattgag cgccgggcct ttggccacac agtccttgtg ggttcccaca ttgtccccca 3840
catgctgcga ttcacatttc ggggtcatga ggatcctcct gaggaggaag gagagatgga 3900
ggagacaggg gatatgatgc ccaagggacc tcaaggacag aagtccctgg atcccttctt 3960
ggctgaagcg ggtatatcca gacagctcct gaagcctcct ctgaagaagc tcccactagg 4020
aggcctccta aatcaaggcc ctgggctgga ggaagacatc ccagatccag aggagctcga 4080
ctgggggtcc aagtactatg cgtcgctgca ggagctccag gggcagcaca actttgatga 4140
agatgaaatg gatgatcctg gagattcaga tggggtcaac ctcatttcta tggttgggga 4200
gatccaagac caggatctac aacaggtccc tgaaggaaga atttaaccac tttgaagact 4260
ggctgaatgt gtttcctctg taccgagggc aagggggcca ggatggaggt ggagaagagg 4320
aaggatctgg acaccttgtg ggcaagttca agggctcctt cctcatttac cctgaatcag 4380
aggcagtgtt gttctctgag ccccagatct cccgggggat cccacagaac cggcccatca 4440
agctcctggt cagagtgtat gttgtaaagg ctaccaacct ggctcctgca gaccccaatg 4500
gcaaagcaga cccttacgtg gtggtgagcg ctggccggga gcggcaggac accaaggaac 4560
gctacatccc caagcagctc aaccccatct ttggagagat cctggagcta agcatctctc 4620
tcccagctga gacggagctg acggtcgccg tatttgatca tgacctcgtg ggttctgacg 4680
acctcatcgg ggagacccac attgatctgg aaaaccgatt ctatagccac cacagagcaa 4740
actgtgggct ggcctcccag tatgaagtgt gggtccagca gggcccacag gagccattct 4800
gagtttctgg ccaaacacat tcaagctcac attccctttt gtgtctccag atcctatgat 4860
ttcatggaag gggaccctcc cacccaccgc cactgccaac caagacatag ctcagtggtc 4920
aagacttggg cttgggagtc gggatcctgt aacgaatgtc acttgaccgc tttctttttt 4980
tatgaaacag tctcgctctg tctcccaggt tggagtgcag tggcacgatc tcggctgact 5040
gcaacctcca cctcctgggt tcaagcgatt ctcctgcctc agcctcccca gtagctggga 5100
ttacaggcgt gggcccccat gtccagctaa tttttatatt ttcgctctgt ctcccaggtt 5160
ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt caagcgattc 5220
tcctgcctca gcctccccag tagctgggat tacaggcgtg ggcccccatg tccagctaat 5280
ttttatattt ttagtagaga cagggtttca ccatgttgtc caggctggtc ttgaacccct 5340
gacctcaagt gatccaccca cctctgcctc ccaaagtgct gggattacag gtgtgagcca 5400
ccatgccagg ccctcttaac ctcttcaagt ctgttttctc atctgcaaaa cagaggtaat 5460
aagatcagta tcttcttaat ggaagcacct ggactacatt tttttcattc attgttatca 5520
taaatgagga ctaacctgtc tcccgttggg agttttgaac ctagacctca tgtcttcatg 5580
acgtcatcac tgccccaggc ccagctgtgt ccctacacca gccccagctg acgcatcttc 5640
tttttctgcc tgtagagatg gttacaatgc ctggcgtgat gcattctggc cttcgcagat 5700
cctggcgggg ctgtgccaac gctgtggcct ccctgcccct gaataccgag ccggtgctgt 5760
caaggtgggc agcaaagtct tcctgacacc accggagacc ctgcccccag ggatctcttc 5820
acatgtggat tgacatcttt cctcaagatg tgcctgctcc acccccagtt gacatcaagc 5880
ctcggcagcc aatcagctat gagctcagag ttgtcatctg gaacacggag gatgtggttc 5940
tggatgacga gaatccactc accggagaga tgtcgagtga catctatgtg aagaggtagg 6000
ctgctggccg ggcggggcaa cggcggtgca ctagggggat tgcaaatggg tgtgggccct 6060
cgggctgagt ccagagcccc gaccccaggc cctccgtggt gctgagagcg gggtgaggag 6120
tgggttctcc atgtagctcc agccctgacg ctcacccacc ccggccccag ctgggtgaag 6180
gggttggagc atgacaagca ggagacagac gttcacttca actccctgac tggggagggg 6240
aacttcaatt ggcgctttgt gttccgcttt gactacctgc ccacggagcg ggaggtgagc 6300
gtctggcgca ggtctggacc ctttgccctg gaggaggcgg agttccggca gcctgcagtg 6360
ctggtcctgc aggtctggga ctatgaccgc atctctgcca atgacttcct tggatccctg 6420
gagttgcagc taccagacat ggtgcgtggg gcccggggcc ccgagctctg ctctgtgcag 6480
ctggcccgca atggggccgg gccgaggtgc aatctgtttc gctgccgccg cctgaggggc 6540
tggtggccgg tagtgaagct gaaggaggca gaggacgtgg agcgggaggc gcaggaggct 6600
caggctggca agaagaagcg aaagcagagg aggaggaagg gccggccaga agacctggag 6660
ttcacagaca tgggtggcaa tgtgtacatc ctcacgggca aggtggaggc agagtttgag 6720
ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa gcagccagag 6780
cctctggaga aacccagccg ccccaaaact tccttcaact ggtttgtgaa cccgctgaag 6840
acctttgtct tcttcatctg gcgccggtac tggcgcaccc tggtgctgct gctactggtg 6900
ctgctcaccg tcttcctcct cctggtcttc tacaccatcc ctggccagat cagccaggtc 6960
atcttccgtc ccctccacaa gtgactctcg ctgaccttgg acactcaccc agggtgccaa 7020
cccttcaatg cctgctcctg gaagtctttc ttacccatgt gagctacccc agagtctagt 7080
gcttcctctg aataaaccta tcacagcc                                    7108



<210> 343
<211> 1995
<212> DNA
<213> Homo sapiens

<400> 343
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggcccact taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctgggct acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggacga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgv agctgggtga aggggttgga gcatgacaag caggagacag 1080
acgttcactt caactccctg vactggggag gggaacttca attggcgctt tgtgttccgc 1140
tttgactacc tgcccacgga gvcgggaggt gagcatccgg cgcaggtctg gaccctttgc 1200
cctggaggag gcggagttcc ggvcagcctg cagtgctggt cctgcaggtc tgggactatg 1260
accgcatctc tgccaatgac ttcvcttgga tccctggagt tgcagctacc agacatggtg 1320
cgtggggccc ggggccccga gctcvtgctc tgtgcagctg gcccgcaatg gggccgggcc 1380
gaggtgcaat ctgtttcgct gccgcvcgcc tgaggggctg gtggccggta gtgaagctga 1440
aggaggcaga ggacgtggag cgggagvgcg caggaggctc aggctggcaa gaagaagcga 1500
aagcagagga ggaggaaggg ccggccavga agacctggag ttcacagaca tgggtggcaa 1560
tgtgtacatc ctcacgggca aggtggagvg cagagtttga gctgctgact gtggaggagg 1620
ccgagaaacg gccagtgggg aaggggcggv aagcagccag agcctctgga gaaacccagc 1680
cgccccaaaa cttccttcaa ctggtttgtg vaacccgctg aagacctttg tcttcttcat 1740
ctggcgccgg tactggcgca ccctggtgct gvctgctact ggtgctgctc accgtcttcc 1800
tcctcctggt cttctacacc atccctggcc agvatcagcc aggtcatctt ccgtcccctc 1860
cacaagtgac tctcgctgac cttggacact cacvccaggg tgccaaccct tcaatgcctg 1920
ctcctggaag tctttcttac ccatgtgagc taccvccaga gtctagtgct tcctctgaat 1980
aaacctatca cagcc                                                  1995

<210> 344
<211> 1995
<212> DNA
<213> Homo sapiens

<400> 344
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgv agctgggtga aggggttgga gcatgacaag caggagacag 1080
acgttcactt caactccctg vactggggag gggaacttca attggcgctt tgtgttccgc 1140
tttgactacc tgcccacgga gvcgggaggt gagcgtctgg cgcaggtctg gaccctttgc 1200
cctggaggag gcggagttcc ggvcagcctg cagtgctggt cctgcaggtc tgggactatg 1260
accgcatctc tgccaatgac ttcvcttgga tccctggagt tgcagctacc agacatggtg 1320
cgtggggccc ggggccccga gctcvtgctc tgtgcagctg gcccgcaatg gggccgggcc 1380
gaggtgcaat ctgtttcgct gccgcvcgcc tgaggggctg gtggccggta gtgaagctga 1440
aggaggcaga ggacgtggag cgggagvgcg caggaggctc aggctggcaa gaagaagcga 1500
aagcagagga ggaggaaggg ccggccavga agacctggag ttcacagaca tgggtggcaa 1560
tgtgtacatc ctcacgggca aggtggagvg cagagtttga gctgctgact gtggaggagg 1620
ccgagaaacg gccagtgggg aaggggcggv aagcagccag agcctctgga gaaacccagc 1680
cgccccaaaa cttccttcaa ctggtttgtg vaacccgctg aagacctttg tcttcttcat 1740
ctggcgccgg tactggcgca ccctggtgct gvctgctact ggtgctgctc accgtcttcc 1800
tcctcctggt cttctacacc atccctggcc agvatcagcc aggtcatctt ccgtcccctc 1860
cacaagtgac tctcgctgac cttggacact cacvccaggg tgccaaccct tcaatgcctg 1920
ctcctggaag tctttcttac ccatgtgagc taccvccaga gtctagtgct tcctctgaat 1980
aaacctatca cagcc                                                  1995

<210> 345
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 345
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Asp Leu Pro Glu Gln Pro Tyr Leu
            1220                1225                1230        
Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His
        1235                1240                1245            
Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr
    1250                1255                1260                
Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu
1265                1270                1275                1280
Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp
                1285                1290                1295    
Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro
            1300                1305                1310        
Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu
        1315                1320                1325            
Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr
    1330                1335                1340                
Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp
1345                1350                1355                1360
Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met
                1365                1370                1375    
Val Gly Glu Ile Gln Asp Gln Asp Leu Gln Gln Val Pro Glu Gly Arg
            1380                1385                1390        
Ile
    


<210> 346
<211> 6303
<212> DNA
<213> Homo sapiens

<400> 346
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gaccatggct ctgacggtaa gcgtgcaacg actaacaggg ctgaccggca cccacgaccg 120
acaagtgaag ctcacctttc gaggctttac ccagaaaaca agaaaaattc actgtggtcc 180
agaagcagat atcggtgagc tgttccgatg gccccactat ggggctccac tggctgggga 240
gtgtctgtct gtgcaggtgg tcaactgcag ccgtgtattc agccttaggc ctctagggac 300
cctggtgatc tccctgcagc agctacagaa tgctgggcat ttggtgctac gggaagccct 360
agtggatgag aatcttcaag tgtccccgat ccaggtggag cttgacctga agtaccagcc 420
cccagagggc gctactggag cctggtcaga ggaggacttt ggggcaccca tccaggacag 480
cttcgagtta atcatcccca atgtgggctt ccaggaactg gagcctgggg aggcccagct 540
ggagcggcgg gcagtggctc taggccgcag gctagctcga agtctaggcc agcaggacga 600
tgaagagaat gagctggagc ttgagctgga gcaggacctg gatgatgagc ctgacgtgga 660
actttctggt gttatgttca gccccctcaa gagccgcgcc agggccctgg cccatgggga 720
tcccttccag gtgtccagag ctcaagactt ccaggtggga gtcactgtgc tggaagccca 780
gaaactggtg ggagtcaaca ttaaccccta tgtggccgtg caagtggggg ggcagcgccg 840
tgtgaccgcc acacagcgtg ggaccagttg ccccttctac aatgagtact tcttgttcga 900
atttcatgac acgcggcttc gtctccaaga cttgctgctg gagatcacgg tgagtggggt 960
aggggtgacc agtgtccttc agagaagggg ggatgagaaa gctgcaggac taacaccacc 1020
ttcccccaag gctttccatt cgcagaccct cccctttatg gccacccgga taggcacctt 1080
caggatggac ctgggcatca tcttggacca gccagatggc cagttctacc aaagatgggt 1140
tccgctgcat gatccccgag acacccgcgc cgggaccaag ggtttcatta aggtcacctt 1200
gtccgtgagg gcgcgcgggg acctgccccc tccaatgcta cccccggccc cagggcactg 1260
ttcggacatc gagaagaacc tgctcctgcc gcgcggggtg cccgccgaga ggccatgggc 1320
gcggctccgc gtgcgcctgt accgcgccga ggggcttccc gcgctgcgcc tggggctgct 1380
gggcagcctg gtccgcgccc tgcacgacca gcgcgtcctg gtggagccct atgtgcgggt 1440
gtctttcctg gggcaggagg gcgagacgtc ggtgagcgcc gaggcggcgg cgcccgaatg 1500
gaacgagcag ctgagcttcg tggagctctt cccgccgctg acgcgcagcc tccgcctgca 1560
gctgcgggac gacgcgcccc tggtcgacgc ggcactcgct acgcacgtgc cggacctgag 1620
gcggatctcc catccgggcc gcgcggcggg gtttaaccct accttcggcc cggcctgggt 1680
gcccctctat ggctcgcccc ccggcgcggg gctccgggat agtcttcaag gtctcaacga 1740
aggcgttggc caaggcattt ggttccgcgg ccgccttctg ctggctgtgt ccatgcaggt 1800
gttggaaggg agagctgaac ctgagcctcc ccaggcccag caggggtcca cgttgtcccg 1860
gctcacccga aagaagaaaa agaaagccag aagggatcag accccaaagg cggttccgca 1920
gcacttggac gccagccccg gtgccgaggg gcctgagatc ccccgtgcca tggaggtgga 1980
ggtggaggag ctgctgccgc tgccagagaa tgtcctggcg ccctgtgaag atttcctgct 2040
tttcggtgtg ctcttcgagg ccaccatgat cgaccccacc gtggcctccc agcccatcag 2100
cttcgagatc tccattggtc gcgcaggccg tctggaggag caattgggcc gagggtccag 2160
ggctggggag ggaactgagg gtgcagccgt ggaggctcag cctctgctgg gagccaggcc 2220
agaggaggag aaagaggagg aagaactggg gacccatgct cagcggcctg agcccatgga 2280
cggcagtggg ccatacttct gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg 2340
gagttgctgg gaggaccaca cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc 2400
cgagaggctg gaccaggggc tgcaggaggt tgagagactg cagcgcaagc cggggcctgg 2460
cgcctgtgca cagctcaagc aggcactgga agtactggtg gctgggagca gacagttttg 2520
ccacggtgcc gagcgcagga cgatgacccg gcccaatgcc ctggatcgat gccgagggaa 2580
actcctggtg cacagcctga accttttggc taagcaagga ctgcgacttc tacgcggcct 2640
gagacggcgc aatgtgcaaa agaaggtggc actggccaag aagctcctgg caaaactgcg 2700
ctttctggct gaggagcaca actttgatga agatgaaatg gatgatcctg gagattcaga 2760
tggggtcaac ctcatttcta tggttgggga gatccaagac cagggtgagg ctgaagtcaa 2820
aggcactgtg tccccaaaaa aagcagttgc caccctgaag atctacaaca ggtccctgaa 2880
ggaagaattt aaccactttg aagactggct gaatgtgttt cctctgtacc gagggcaagg 2940
gggccaggat ggaggtggag aagaggaagg atctggacac cttgtgggca agttcaaggg 3000
ctccttcctc atttaccctg aatcagaggc agtgttgttc tctgagcccc agatctcccg 3060
ggggatccca cagaaccggc ccatcaagct cctggtcaga gtgtatgttg taaagctaag 3120
aaacctttgc aaaatccaag gtcatgaaga cttttgcctg ttttctgctg ctaccaacct 3180
ggctcctgca gaccccaatg gcaaagcaga cccttacgtg gtggtgagcg ctggccggga 3240
gcggcaggac accaaggaac gctacatccc caagcagctc aaccccatct ttggagagat 3300
cctggagcta agcatctctc tcccagctga gacggagctg acggtcgccg tatttgatca 3360
tgacctcgtg ggttctgacg acctcatcgg ggagacccac attgatctgg aaaaccgatt 3420
ctatagccac cacagagcaa actgtgggct ggcctcccag tatgaagtgt gggtccagca 3480
gggcccacag gagccattct gagtttctgg ccaaacacat tcaagctcac attccctttt 3540
gtgtctccag atcctatgat ttcatggaag gggaccctcc cacccaccgc cactgccaac 3600
caagacatag ctcagtggtc aagacttggg cttgggagtc gggatcctgt aacgaatgtc 3660
acttgaccgc tttctttttt tatgaaacag tctcgctctg tctcccaggt tggagtgcag 3720
tggcacgatc tcggctgact gcaacctcca cctcctgggt tcaagcgatt ctcctgcctc 3780
agcctcccca gtagctggga ttacaggcgt gggcccccat gtccagctaa tttttatatt 3840
ttcgctctgt ctcccaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac 3900
ctcctgggtt caagcgattc tcctgcctca gcctccccag tagctgggat tacaggcgtg 3960
ggcccccatg tccagctaat ttttatattt ttagtagaga cagggtttca ccatgttgtc 4020
caggctggtc ttgaacccct gacctcaagt gatccaccca cctctgcctc ccaaagtgct 4080
gggattacag gtgtgagcca ccatgccagg ccctcttaac ctcttcaagt ctgttttctc 4140
atctgcaaaa cagaggtaat aagatcagta tcttcttaat ggaagcacct ggactacatt 4200
tttttcattc attgttatca taaatgagga ctaacctgtc tcccgttggg agttttgaac 4260
ctagacctca tgtcttcatg acgtcatcac tgccccaggc ccagctgtgt ccctacacca 4320
gccccagctg acgcatcttc tttttctgcc tgtagagatg gttacaatgc ctggcgtgat 4380
gcattctggc cttcgcagat cctggcgggg ctgtgccaac gctgtggcct ccctgcccct 4440
gaataccgag ccggtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 4500
ctgcccccag ggatctcttc acatgtggat tgacatcttt cctcaagatg tgcctgctcc 4560
acccccagtt gacatcaagc ctcggcagcc aatcagctat gagctcagag ttgtcatctg 4620
gaacacggag gatgtggttc tggatgacga gaatccactc accggagaga tgtcgagtga 4680
catctatgtg aagaggtagg ctgctggccg ggcggggcaa cggcggtgca ctagggggat 4740
tgcaaatggg tgtgggccct cgggctgagt ccagagcccc gaccccaggc cctccgtggt 4800
gctgagagcg gggtgaggag tgggttctcc atgtagctcc agccctgacg ctcacccacc 4860
ccggccccag ctgggtgaag gggttggagc atgacaagca ggagacagac gttcacttca 4920
actccctgac tggggagggg aacttcaatt ggcgctttgt gttccgcttt gactacctgc 4980
ccacggagcg ggaggtgagc gtctggcgca ggtctggacc ctttgccctg gaggaggcgg 5040
agttccggca gcctgcagtg ctggtcctgc aggtctggga ctatgaccgc atctctgcca 5100
atgacttcct tggtattaca atgcttagcc ttccccaccc tcagcccctg cctccagccc 5160
tcacctccgc ccctgcctcc agccctcact tccgtccccc agttccctac tctgacccaa 5220
ccttgaatct tgggattttg gacccgaggt gtgaaacctt tgctttctgg cctaattact 5280
gagttaatta ggcctagacc acagtaacct ccattcccac ccagagtctc tgattcaact 5340
ctgatttgac cctagcttgt caccctgaca ccgactccac agcctttggt ccttggcact 5400
ctgatcccga cccttggccc tcttccactg ggaagtagca atgggtggac cgctgggctg 5460
tggtctgggt ggtctatagc tgtggcctga ccgcacactg caacaacttt caatgcccca 5520
atttacaacc ttggtgtgtt gcctcctcac ccctggcaca atgagacttt gatcccatgc 5580
ctaatctggt gtgctctgga cttgcaggat ccctggagtt gcagctacca gacatggtgc 5640
gtggggcccg gggccccgag ctctgctctg tgcagctggc ccgcaatggg gccgggccga 5700
ggtgcaatct gtttcgctgc cgccgcctga ggggctggtg gccggtagtg aagctgaagg 5760
aggcagagga cgtggagcgg gaggcgcagg aggctcaggc tggcaagaag aagcgaaagc 5820
agaggaggag gaagggccgg ccagaagacc tggagttcac agacatgggt ggcaatgtgt 5880
acatcctcac gggcaaggtg gaggcagagt ttgagctgct gactgtggag gaggccgaga 5940
aacggccagt ggggaagggg cggaagcagc cagagcctct ggagaaaccc agccgcccca 6000
aaacttcctt caactggttt gtgaacccgc tgaagacctt tgtcttcttc atctggcgcc 6060
ggtactggcg caccctggtg ctgctgctac tggtgctgct caccgtcttc ctcctcctgg 6120
tcttctacac catccctggc cagatcagcc aggtcatctt ccgtcccctc cacaagtgac 6180
tctcgctgac cttggacact cacccagggt gccaaccctt caatgcctgc tcctggaagt 6240
ctttcttacc catgtgagct accccagagt ctagtgcttc ctctgaataa acctatcaca 6300
gcc                                                               6303



<210> 347
<211> 1998
<212> DNA
<213> Homo sapiens

<400> 347
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgv ggatccctgg agttgcagct accagacatg gtgcgtgggg 1080
cccggggccc cgagctctgc vtctgtgcag ctggcccgca atggggccgg gccgaggtgc 1140
aatctgtttc gctgccgccg cvctgagggg ctggtggccg gtagtgaagc tgaaggaggc 1200
agaggacgtg gagcgggagg cgvcaggagg ctcaggctgg caagaagaag cgaaagcaga 1260
ggaggaggaa gggccggcca gaavgacctg gagttcacag acatgggtgg caatgtgtac 1320
atcctcacgg gcaaggtgga ggcavgagtt tgagctgctg actgtggagg aggccgagaa 1380
acggccagtg gggaaggggc ggaagvcagc cagagcctct ggagaaaccc agccgcccca 1440
aaacttcctt caactggttt gtgaacvccg ctgaagacct ttgtcttctt catctggcgc 1500
cggtactggc gcaccctggt gctgctgvct actggtgctg ctcaccgtct tcctcctcct 1560
ggtcttctac accatccctg gccagatcva gccaggtcat cttccgtccc ctccacaagt 1620
gactctcgct gaccttggac actcacccav gggtgccaac ccttcaatgc ctgctcctgg 1680
aagtctttct tacccatgtg agctacccca vgagtctagt gcttcctctg aataaaccta 1740
tcacagccva gctgggtgaa ggggttggag catgacaagc aggagacaga cgttcacttc 1800
aactccctgv actggggagg ggaacttcaa ttggcgcttt gtgttccgct ttgactacct 1860
gcccacggag vcgggaggtg agcgtctggc gcaggtctgg accctttgcc ctggaggagg 1920
cggagttccg gvcagcctgc agtgctggtc ctgcaggtct gggactatga ccgcatctct 1980
gccaatgact tcvcttgg                                               1998

<210> 348
<211> 1998
<212> DNA
<213> Homo sapiens

<400> 348
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgv ggatccctgg agttgcagct accagacatg gtgcgtgggg 1080
cccggggccc cgagctctgc vtctgtgcag ctggcccgca atggggccgg gccgaggtgc 1140
aatctgtttc gctgccgccg cvctgagggg ctggtggccg gtagtgaagc tgaaggaggc 1200
agaggacgtg gagcgggagg cgvcaggagg ctcaggctgg caagaagaag cgaaagcaga 1260
ggaggaggaa gggccggcca gaavgacctg gagttcacag acatgggtgg caatgtgtac 1320
atcctcacgg gcaaggtgga ggcavgagtt tgagctgctg actgtggagg aggccgagaa 1380
acggccagtg gggaaggggc ggaagvcagc cagagcctct ggagaaaccc agccgcccca 1440
aaacttcctt caactggttt gtgaacvccg ctgaagacct ttgtcttctt catctggcgc 1500
cggtactggc gcaccctggt gctgctgvct actggtgctg ctcaccgtct tcctcctcct 1560
ggtcttctac accatccctg gccagatcva gccaggtcat cttccgtccc ctccacaagt 1620
gactctcgct gaccttggac actcacccav gggtgccaac ccttcaatgc ctgctcctgg 1680
aagtctttct tacccatgtg agctacccca vgagtctagt gcttcctctg aataaaccta 1740
tcacagccva gctgggtgaa ggggttggag catgacaagc aggagacaga cgttcacttc 1800
aactccctgv actggggagg ggaacttcaa ttggcgcttt gtgttccgct ttgactacct 1860
gcccacggag vcgggaggtg agcgtctggc gcaggtctgg accctttgcc ctggaggagg 1920
cggagttccg gvcagcctgc agtgctggtc ctgcaggtct gggactatga ccgcatctct 1980
gccaatgact tcvcttgg                                               1998

<210> 349
<211> 1145
<212> PRT
<213> Homo sapiens

<400> 349
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu His Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly
                885                 890                 895     
Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp
            900                 905                 910         
Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val
        915                 920                 925             
Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His
    930                 935                 940                 
Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly
945                 950                 955                 960 
Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys
                965                 970                 975     
Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe
            980                 985                 990         
Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys
        995                 1000                1005            
Leu Leu Val Arg Val Tyr Val Val Lys Leu Arg Asn Leu Cys Lys Ile
    1010                1015                1020                
Gln Gly His Glu Asp Phe Cys Leu Phe Ser Ala Ala Thr Asn Leu Ala
1025                1030                1035                1040
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
                1045                1050                1055    
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
            1060                1065                1070        
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
        1075                1080                1085            
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
    1090                1095                1100                
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
1105                1110                1115                1120
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Trp
                1125                1130                1135    
Val Gln Gln Gly Pro Gln Glu Pro Phe
            1140                1145


<210> 350
<211> 6161
<212> DNA
<213> Homo sapiens

<400> 350
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gaccatggct ctgacggtaa gcgtgcaacg actaacaggg ctgaccggca cccacgaccg 120
acaagtgaag ctcacctttc gaggctttac ccagaaaaca agaaaaattc actgtggtcc 180
agaagcagat atcggtgagc tgttccgatg gccccactat ggggctccac tggctgggga 240
gtgtctgtct gtgcaggtgg tcaactgcag ccgtgtattc agccttaggc ctctagggac 300
cctggtgatc tccctgcagc agctacagaa tgctgggcat ttggtgctac gggaagccct 360
agtggatgag aatcttcaag tgtccccgat ccaggtggag cttgacctga agtaccagcc 420
cccagagggc gctactggag cctggtcaga ggaggacttt ggggcaccca tccaggacag 480
cttcgagtta atcatcccca atgtgggctt ccaggaactg gagcctgggg aggcccagct 540
ggagcggcgg gcagtggctc taggccgcag gctagctcga agtctaggcc agcaggacga 600
tgaagagaat gagctggagc ttgagctgga gcaggacctg gatgatgagc ctgacgtgga 660
actttctggt gttatgttca gccccctcaa gagccgcgcc agggccctgg cccatgggga 720
tcccttccag gtgtccagag ctcaagactt ccaggtggga gtcactgtgc tggaagccca 780
gaaactggtg ggagtcaaca ttaaccccta tgtggccgtg caagtggggg ggcagcgccg 840
tgtgaccgcc acacagcgtg ggaccagttg ccccttctac aatgagtact tcttgttcga 900
atttcatgac acgcggcttc gtctccaaga cttgctgctg gagatcacgg tgagtggggt 960
aggggtgacc agtgtccttc agagaagggg ggatgagaaa gctgcaggac taacaccacc 1020
ttcccccaag gctttccatt cgcagaccct cccctttatg gccacccgga taggcacctt 1080
caggatggac ctgggcatca tcttggacca gccagatggc cagttctacc aaagatgggt 1140
tccgctgcat gatccccgag acacccgcgc cgggaccaag ggtttcatta aggtcacctt 1200
gtccgtgagg gcgcgcgggg acctgccccc tccaatgcta cccccggccc cagggcactg 1260
ttcggacatc gagaagaacc tgctcctgcc gcgcggggtg cccgccgaga ggccatgggc 1320
gcggctccgc gtgcgcctgt accgcgccga ggggcttccc gcgctgcgcc tggggctgct 1380
gggcagcctg gtccgcgccc tgcacgacca gcgcgtcctg gtggagccct atgtgcgggt 1440
gtctttcctg gggcaggagg gcgagacgtc ggtgagcgcc gaggcggcgg cgcccgaatg 1500
gaacgagcag ctgagcttcg tggagctctt cccgccgctg acgcgcagcc tccgcctgca 1560
gctgcgggac gacgcgcccc tggtcgacgc ggcactcgct acgcacgtgc cggacctgag 1620
gcggatctcc catccgggcc gcgcggcggg gtttaaccct accttcggcc cggcctgggt 1680
gcccctctat ggctcgcccc ccggcgcggg gctccgggat agtcttcaag gtctcaacga 1740
aggcgttggc caaggcattt ggttccgcgg ccgccttctg ctggctgtgt ccatgcaggt 1800
gttggaaggg agagctgaac ctgagcctcc ccaggcccag caggggtcca cgttgtcccg 1860
gctcacccga aagaagaaaa agaaagccag aagggatcag accccaaagg cggttccgca 1920
gcacttggac gccagccccg gtgccgaggg gcctgagatc ccccgtgcca tggaggtgga 1980
ggtggaggag ctgctgccgc tgccagagaa tgtcctggcg ccctgtgaag atttcctgct 2040
tttcggtgtg ctcttcgagg ccaccatgat cgaccccacc gtggcctccc agcccatcag 2100
cttcgagatc tccattggtc gcgcaggccg tctggaggag caattgggcc gagggtccag 2160
ggctggggag ggaactgagg gtgcagccgt ggaggctcag cctctgctgg gagccaggcc 2220
agaggaggag aaagaggagg aagaactggg gacccatgct cagcggcctg agcccatgga 2280
cggcagtggg ccatacttct gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg 2340
gagttgctgg gaggaccaca cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc 2400
cgagaggctg gaccaggggc tgcaggaggt tgagagactg cagcgcaagc cggggcctgg 2460
cgcctgtgca cagctcaagc aggcactgga agtactggtg gctgggagca gacagttttg 2520
ccacggtgcc gagcgcagga cgatgacccg gcccaatgcc ctggatcgat gccgagggaa 2580
actcctggtg cacagcctga accttttggc taagcaagga ctgcgacttc tacgcggcct 2640
gagacggcgc aatgtgcaaa agaaggtggc actggccaag aagctcctgg caaaactgcg 2700
ctttctggct gaggagcccc agccacccct ccccgatgtg ctggtctgga tgctcagcgg 2760
gcagcgccgt gtggcctggg cccggatccc tgcccaggat gtgctgttct ctgtggttga 2820
ggaggaacgg ggccgagact gtgggaagat ccagagtcta atgctcacgg cacccggggc 2880
agcccctggt gaggtctgtg ccaagctgga gctcttcctg cggctgggcc tgggcaagca 2940
agccaaggcc tgcacctctg agctgccccc ggatttgctg cccgagccct cagccgggct 3000
gccctccagc ctacaccggg acgactttag ctacttccaa ctccgggctc acttgtacca 3060
ggcccggggt gtgttggctg cagatgacag tggcctctcg gacccctttg ctcgagtcct 3120
catctctacc cagtgtcaga ccacacgggt cctggagcag acgctgagcc ctctgtggga 3180
tgaactcctg gtatttgagc agttgatcgt ggatgggagg agggagcacc tgcaggagga 3240
gcctccatta gtgatcatca atgtatttga ccacaataag tttggccccc ccgtgttcct 3300
gggcagggca ctggccgccc caagggtaaa gctgatggag gacccatacc aacgcccaga 3360
gttgcagttc ttccccctga ggaagggacc ctgggcagcc ggagagctca ttgccgcctt 3420
tcaactcatt gaactagact acagtggccg acttgagccc tcagtgccca gtgaggtgga 3480
gccccaggat ctggcacccc tggttgagcc ccactctgga cgcctgtccc ttccacccaa 3540
cgtgtgccca gtgctcaggg agttccgtgt tgaggtgctg ttctggggtc ttaggggact 3600
tggtcgtgtg catctgctcg aggtggagca gccccaggtt gtactggagg tggctgggca 3660
aggtgtggag tctgaggtcc tggccagcta ccgtgagagc cccaatttca ctgagcttgt 3720
caggcatctg acagtggtct tcaaagacac agctcctctc ttccaccccc aggacttgcc 3780
ggagcagcct tacttgcagc ctccactcag catcttggtg attgagcgcc gggcctttgg 3840
ccacacagtc cttgtgggtt cccacattgt cccccacatg ctgcgattca catttcgggg 3900
tcatgaggat cctcctgagg aggaaggaga gatggaggag acaggggata tgatgcccaa 3960
gggacctcaa ggacagaagt ccctggatcc cttcttggct gaagcgggta tatccagaca 4020
gctcctgaag cctcctctga agaagctccc actaggaggc ctcctaaatc aaggccctgg 4080
gctggaggaa gacatcccag atccagagga gctcgactgg gggtccaagt actatgcgtc 4140
gctgcaggag ctccaggggc agcacaactt tgatgaagat gaaatggatg atcctggaga 4200
ttcagatggg gtcaacctca tttctatggt tggggagatc caagaccagg gtgaggctga 4260
agtcaaaggc actgtgtccc caaaaaaagc agttgccacc ctgaagatct acaacaggtc 4320
cctgaaggaa gaatttaacc actttgaaga ctggctgaat gtgtttcctc tgtaccgagg 4380
gcaagggggc caggatggag gtggagaaga ggaaggatct ggacaccttg tgggcaagtt 4440
caagggctcc ttcctcattt accctgaatc agaggcagtg ttgttctctg agccccagat 4500
ctcccggggg atcccacaga accggcccat caagctcctg gtcagagtgt atgttgtaaa 4560
ggctaccaac ctggctcctg cagaccccaa tggcaaagca gacccttacg tggtggtgag 4620
cgctggccgg gagcggcagg acaccaagga acgctacatc cccaagcagc tcaaccccat 4680
ctttggagag atcctggagc taagcatctc tctcccagct gagacggagc tgacggtcgc 4740
cgtatttgat catgacctcg tgggttctga cgacctcatc ggggagaccc acattgatct 4800
ggaaaaccga ttctatagcc accacagagc aaactgtggg ctggcctccc agtatgaagt 4860
agatggttac aatgcctggc gtgatgcatt ctggccttcg cagatcctgg cggggctgtg 4920
ccaacgctgt ggcctccctg cccctgaata ccgagccggt gctgtcaagg tgggcagcaa 4980
agtcttcctg acaccaccgg agaccctgcc cccagtggcg agcggggacc ctgaagaggc 5040
ccaggcattg cttgtgctgc ggcgctggca ggaaatgccg ggttttggga tccagctggt 5100
acccgagcat gtagaaacca ggcctctcta ccatccccac agcccagggc tgctacaggg 5160
atctcttcac atgtggattg acatctttcc tcaagatgtg cctgctccac ccccagttga 5220
catcaagcct cggcagccaa tcagctatga gctcagagtt gtcatctgga acacggagga 5280
tgtggttctg gatgacgaga atccactcac cggagagatg tcgagtgaca tctatgtgaa 5340
gagctgggtg aaggggttgg agcatgacaa gcaggagaca gacgttcact tcaactccct 5400
gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc tgcccacgga 5460
gcgggaggtg agcgtctggc gcaggtctgg accctttgcc ctggaggagg cggagttccg 5520
gcagcctgca gtgctggtcc tgcaggtctg ggactatgac cgcatctctg ccaatgactt 5580
ccttggatcc ctggagttgc agctaccaga catggtgcgt ggggcccggg gccccgagct 5640
ctgctctgtg cagctggccc gcaatggggc cgggccgagg tgcaatctgt ttcgctgccg 5700
ccgcctgagg ggctggtggc cggtagtgaa gctgaaggag gcagaggacg gcaaggtgga 5760
ggcagagttt gagctgctga ctgtggagga ggccgagaaa cggccagtgg ggaaggggcg 5820
gaagcagcca gagcctctgg agaaacccag ccgccccaaa acttccttca actggtttgt 5880
gaacccgctg aagacctttg tcttcttcat ctggcgccgg tactggcgca ccctggtgct 5940
gctgctactg gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca 6000
gatcagccag gtcatcttcc gtcccctcca caagtgactc tcgctgacct tggacactca 6060
cccagggtgc caacccttca atgcctgctc ctggaagtct ttcttaccca tgtgagctac 6120
cccagagtct agtgcttcct ctgaataaac ctatcacagc c                     6161



<210> 351
<211> 1182
<212> DNA
<213> Homo sapiens

<400> 351
vcagggatct cttcacatgt ggattgacat ctttcctcaa gatgtgcctg ctccaccccc 60
avgttgacat caagcctcgg cagccaatca gctatgagct cagagttgtc atctggaaca 120
cgvgaggatg tggttctgga tgacgagaat ccactcaccg gagagatgtc gagtgacatc 180
tatvgtgaag agctgggtga aggggttgga gcatgacaag caggagacag acgttcactt 240
caacvtccct gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc 300
tgcccvacgg agcgggaggt gagcgtctgg cgcaggtctg gaccctttgc cctggaggag 360
gcggagvttc cggcagcctg cagtgctggt cctgcaggtc tgggactatg accgcatctc 420
tgccaatvga cttccttgga tccctggagt tgcagctacc agacatggtg cgtggggccc 480
ggggccccvg agctctgctc tgtgcagctg gcccgcaatg gggccgggcc gaggtgcaat 540
ctgtttcgcv tgccgccgcc tgaggggctg gtggccggta gtgaagctga aggaggcaga 600
ggacgvggca aggtggaggc agagtttgag ctgctgactg tggaggaggc cgagaaacgg 660
ccagtgvggg aaggggcgga agcagccaga gcctctggag aaacccagcc gccccaaaac 720
ttccttcvaa ctggtttgtg aacccgctga agacctttgt cttcttcatc tggcgccggt 780
actggcgcva ccctggtgct gctgctactg gtgctgctca ccgtcttcct cctcctggtc 840
ttctacaccv atccctggcc agatcagcca ggtcatcttc cgtcccctcc acaagtgact 900
ctcgctgacc vttggacact cacccagggt gccaaccctt caatgcctgc tcctggaagt 960
ctttcttacc cvatgtgagc taccccagag tctagtgctt cctctgaata aacctatcac 1020
agccvagatg gttacaatgc ctggcgtgat gcattctggc cttcgcagat cctggcgggg 1080
ctgtgvccaa cgctgtggcc tccctgcccc tgaataccga gccggtgctg tcaaggtggg 1140
cagcaavagt cttcctgaca ccaccggaga ccctgccccc ag                    1182

<210> 352
<211> 1182
<212> DNA
<213> Homo sapiens

<400> 352
vcagggatct cttcacatgt ggattgacat ctttcctcaa gatgtgcctg ctccaccccc 60
avgttgacat caagcctcgg cagccaatca gctatgagct cagagttgtc atctggaaca 120
cgvgaggatg tggttctgga tgacgagaat ccactcaccg gagagatgtc gagtgacatc 180
tatvgtgaag agctgggtga aggggttgga gcatgacaag caggagacag acgttcactt 240
caacvtccct gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc 300
tgcccvacgg agcgggaggt gagcgtctgg cgcaggtctg gaccctttgc cctggaggag 360
gcggagvttc cggcagcctg cagtgctggt cctgcaggtc tgggactatg accgcatctc 420
tgccaatvga cttccttgga tccctggagt tgcagctacc agacatggtg cgtggggccc 480
ggggccccvg agctctgctc tgtgcagctg gcccgcaatg gggccgggcc gaggtgcaat 540
ctgtttcgcv tgccgccgcc tgaggggctg gtggccggta gtgaagctga aggaggcaga 600
ggacgvggca aggtggaggc agagtttgag ctgctgactg tggaggaggc cgagaaacgg 660
ccagtgvggg aaggggcgga agcagccaga gcctctggag aaacccagcc gccccaaaac 720
ttccttcvaa ctggtttgtg aacccgctga agacctttgt cttcttcatc tggcgccggt 780
actggcgcva ccctggtgct gctgctactg gtgctgctca ccgtcttcct cctcctggtc 840
ttctacaccv atccctggcc agatcagcca ggtcatcttc cgtcccctcc acaagtgact 900
ctcgctgacc vttggacact cacccagggt gccaaccctt caatgcctgc tcctggaagt 960
ctttcttacc cvatgtgagc taccccagag tctagtgctt cctctgaata aacctatcac 1020
agccvagatg gttacaatgc ctggcgtgat gcattctggc cttcgcagat cctggcgggg 1080
ctgtgvccaa cgctgtggcc tccctgcccc tgaataccga gccggtgctg tcaaggtggg 1140
cagcaavagt cttcctgaca ccaccggaga ccctgccccc ag                    1182

<210> 353
<211> 1990
<212> PRT
<213> Homo sapiens

<400> 353
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Val Ala Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val
    1650                1655                1660                
Leu Arg Arg Trp Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro
1665                1670                1675                1680
Glu His Val Glu Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu
                1685                1690                1695    
Leu Gln Gly Ser Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val
            1700                1705                1710        
Pro Ala Pro Pro Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr
        1715                1720                1725            
Glu Leu Arg Val Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp
    1730                1735                1740                
Glu Asn Pro Leu Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser
1745                1750                1755                1760
Trp Val Lys Gly Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe
                1765                1770                1775    
Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg
            1780                1785                1790        
Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser
        1795                1800                1805            
Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu
    1810                1815                1820                
Val Leu Gln Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu
1825                1830                1835                1840
Gly Ser Leu Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly
                1845                1850                1855    
Pro Glu Leu Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg
            1860                1865                1870        
Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val
        1875                1880                1885            
Lys Leu Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Glu Leu
    1890                1895                1900                
Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys
1905                1910                1915                1920
Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn
                1925                1930                1935    
Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg
            1940                1945                1950        
Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe
        1955                1960                1965            
Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile
    1970                1975                1980                
Phe Arg Pro Leu His Lys
1985                1990


<210> 354
<211> 334
<212> PRT
<213> Homo sapiens

<400> 354
Val Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro
 1               5                  10                  15      
Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val
            20                  25                  30          
Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr
        35                  40                  45              
Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Val Lys Gly
    50                  55                  60                  
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
65                  70                  75                  80  
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
                85                  90                  95      
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
            100                 105                 110         
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Val Leu Val Leu Gln
        115                 120                 125             
Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu
    130                 135                 140                 
Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu
145                 150                 155                 160 
Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu
                165                 170                 175     
Phe Arg Cys Arg Arg Leu Arg Val Gly Trp Trp Pro Val Val Lys Leu
            180                 185                 190         
Lys Glu Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly
        195                 200                 205             
Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu
    210                 215                 220                 
Glu Phe Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val
225                 230                 235                 240 
Glu Ala Glu Phe Val Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg
                245                 250                 255     
Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser
            260                 265                 270         
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe
        275                 280                 285             
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu
    290                 295                 300                 
Leu Val Val Leu Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile
305                 310                 315                 320 
Pro Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu His Lys
                325                 330                 


<210> 355
<211> 294
<212> PRT
<213> Homo sapiens

<400> 355
Val Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro
 1               5                  10                  15      
Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val
            20                  25                  30          
Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr
        35                  40                  45              
Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Val Lys Gly
    50                  55                  60                  
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
65                  70                  75                  80  
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
                85                  90                  95      
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
            100                 105                 110         
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Val Leu Val Leu Gln
        115                 120                 125             
Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu
    130                 135                 140                 
Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu
145                 150                 155                 160 
Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu
                165                 170                 175     
Phe Arg Cys Arg Arg Leu Arg Val Gly Trp Trp Pro Val Val Lys Leu
            180                 185                 190         
Lys Glu Ala Glu Asp Gly Lys Val Glu Ala Glu Phe Val Glu Leu Leu
        195                 200                 205             
Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln
    210                 215                 220                 
Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp
225                 230                 235                 240 
Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr
                245                 250                 255     
Trp Arg Thr Leu Val Leu Leu Leu Leu Val Val Leu Leu Thr Val Phe
            260                 265                 270         
Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile
        275                 280                 285             
Phe Arg Pro Leu His Lys
    290                 


<210> 356
<211> 6299
<212> DNA
<213> Homo sapiens

<400> 356
caggtgggcg ggctggtggg cagaagggca gacgggcaga ggaagtgcca gtgccactgg 60
gaccatggct ctgacggtaa gcgtgcaacg actaacaggg ctgaccggca cccacgaccg 120
acaagtgaag ctcacctttc gaggctttac ccagaaaaca agaaaaattc actgtggtcc 180
agaagcagat atcggtgagc tgttccgatg gccccactat ggggctccac tggctgggga 240
gtgtctgtct gtgcaggtgg tcaactgcag ccgtgtattc agccttaggc ctctagggac 300
cctggtgatc tccctgcagc agctacagaa tgctgggcat ttggtgctac gggaagccct 360
agtggatgag aatcttcaag tgtccccgat ccaggtggag cttgacctga agtaccagcc 420
cccagagggc gctactggag cctggtcaga ggaggacttt ggggcaccca tccaggacag 480
cttcgagtta atcatcccca atgtgggctt ccaggaactg gagcctgggg aggcccagct 540
ggagcggcgg gcagtggctc taggccgcag gctagctcga agtctaggcc agcaggacga 600
tgaagagaat gagctggagc ttgagctgga gcaggacctg gatgatgagc ctgacgtgga 660
actttctggt gttatgttca gccccctcaa gagccgcgcc agggccctgg cccatgggga 720
tcccttccag gtgtccagag ctcaagactt ccaggtggga gtcactgtgc tggaagccca 780
gaaactggtg ggagtcaaca ttaaccccta tgtggccgtg caagtggggg ggcagcgccg 840
tgtgaccgcc acacagcgtg ggaccagttg ccccttctac aatgagtact tcttgttcga 900
atttcatgac acgcggcttc gtctccaaga cttgctgctg gagatcacgg tgagtggggt 960
aggggtgacc agtgtccttc agagaagggg ggatgagaaa gctgcaggac taacaccacc 1020
ttcccccaag gctttccatt cgcagaccct cccctttatg gccacccgga taggcacctt 1080
caggatggac ctgggcatca tcttggacca gccagatggc cagttctacc aaagatgggt 1140
tccgctgcat gatccccgag acacccgcgc cgggaccaag ggtttcatta aggtcacctt 1200
gtccgtgagg gcgcgcgggg acctgccccc tccaatgcta cccccggccc cagggcactg 1260
ttcggacatc gagaagaacc tgctcctgcc gcgcggggtg cccgccgaga ggccatgggc 1320
gcggctccgc gtgcgcctgt accgcgccga ggggcttccc gcgctgcgcc tggggctgct 1380
gggcagcctg gtccgcgccc tgcacgacca gcgcgtcctg gtggagccct atgtgcgggt 1440
gtctttcctg gggcaggagg gcgagacgtc ggtgagcgcc gaggcggcgg cgcccgaatg 1500
gaacgagcag ctgagcttcg tggagctctt cccgccgctg acgcgcagcc tccgcctgca 1560
gctgcgggac gacgcgcccc tggtcgacgc ggcactcgct acgcacgtgc cggacctgag 1620
gcggatctcc catccgggcc gcgcggcggg gtttaaccct accttcggcc cggcctgggt 1680
gcccctctat ggctcgcccc ccggcgcggg gctccgggat agtcttcaag gtctcaacga 1740
aggcgttggc caaggcattt ggttccgcgg ccgccttctg ctggctgtgt ccatgcaggt 1800
gttggaaggg agagctgaac ctgagcctcc ccaggcccag caggggtcca cgttgtcccg 1860
gctcacccga aagaagaaaa agaaagccag aagggatcag accccaaagg cggttccgca 1920
gcacttggac gccagccccg gtgccgaggg gcctgagatc ccccgtgcca tggaggtgga 1980
ggtggaggag ctgctgccgc tgccagagaa tgtcctggcg ccctgtgaag atttcctgct 2040
tttcggtgtg ctcttcgagg ccaccatgat cgaccccacc gtggcctccc agcccatcag 2100
cttcgagatc tccattggtc gcgcaggccg tctggaggag caattgggcc gagggtccag 2160
ggctggggag ggaactgagg gtgcagccgt ggaggctcag cctctgctgg gagccaggcc 2220
agaggaggag aaagaggagg aagaactggg gacccatgct cagcggcctg agcccatgga 2280
cggcagtggg ccatacttct gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg 2340
gagttgctgg gaggaccaca cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc 2400
cgagaggctg gaccaggggc tgcaggaggt tgagagactg cagcgcaagc cggggcctgg 2460
cgcctgtgca cagctcaagc aggcactgga agtactggtg gctgggagca gacagttttg 2520
ccacggtgcc gagcgcagga cgatgacccg gcccaatgcc ctggatcgat gccgagggaa 2580
actcctggtg cacagcctga accttttggc taagcaagga ctgcgacttc tacgcggcct 2640
gagacggcgc aatgtgcaaa agaaggtggc actggccaag aagctcctgg caaaactgcg 2700
ctttctggct gaggagcccc agccacccct ccccgatgtg ctggtctgga tgctcagcgg 2760
gcagcgccgt gtggcctggg cccggatccc tgcccaggat gtgctgttct ctgtggttga 2820
ggaggaacgg ggccgagact gtgggaagat ccagagtcta atgctcacgg cacccggggc 2880
agcccctggt gaggtctgtg ccaagctgga gctcttcctg cggctgggcc tgggcaagca 2940
agccaaggcc tgcacctctg agctgccccc ggatttgctg cccgagccct cagccgggct 3000
gccctccagc ctacaccggg acgactttag ctacttccaa ctccgggctc acttgtacca 3060
ggcccggggt gtgttggctg cagatgacag tggcctctcg gacccctttg ctcgagtcct 3120
catctctacc cagtgtcaga ccacacgggt cctggagcag acgctgagcc ctctgtggga 3180
tgaactcctg gtatttgagc agttgatcgt ggatgggagg agggagcacc tgcaggagga 3240
gcctccatta gtgatcatca atgtatttga ccacaataag tttggccccc ccgtgttcct 3300
gggcagggca ctggccgccc caagggtaaa gctgatggag gacccatacc aacgcccaga 3360
gttgcagttc ttccccctga ggaagggacc ctgggcagcc ggagagctca ttgccgcctt 3420
tcaactcatt gaactagact acagtggccg acttgagccc tcagtgccca gtgaggtgga 3480
gccccaggat ctggcacccc tggttgagcc ccactctgga cgcctgtccc ttccacccaa 3540
cgtgtgccca gtgctcaggg agttccgtgt tgaggtgctg ttctggggtc ttaggggact 3600
tggtcgtgtg catctgctcg aggtggagca gccccaggtt gtactggagg tggctgggca 3660
aggtgtggag tctgaggtcc tggccagcta ccgtgagagc cccaatttca ctgagcttgt 3720
caggcatctg acagtggtct tcaaagacac agctcctctc ttccaccccc aggacttgcc 3780
ggagcagcct tacttgcagc ctccactcag catcttggtg attgagcgcc gggcctttgg 3840
ccacacagtc cttgtgggtt cccacattgt cccccacatg ctgcgattca catttcgggg 3900
tcatgaggat cctcctgagg aggaaggaga gatggaggag acaggggata tgatgcccaa 3960
gggacctcaa ggacagaagt ccctggatcc cttcttggct gaagcgggta tatccagaca 4020
gctcctgaag cctcctctga agaagctccc actaggaggc ctcctaaatc aaggccctgg 4080
gctggaggaa gacatcccag atccagagga gctcgactgg gggtccaagt actatgcgtc 4140
gctgcaggag ctccaggggc agcacaactt tgatgaagat gaaatggatg atcctggaga 4200
ttcagatggg gtcaacctca tttctatggt tggggagatc caagaccagg gtgaggctga 4260
agtcaaaggc actgtgtccc caaaaaaagc agttgccacc ctgaagatct acaacaggtc 4320
cctgaaggaa gaatttaacc actttgaaga ctggctgaat gtgtttcctc tgtaccgagg 4380
gcaagggggc caggatggag gtggagaaga ggaaggatct ggacaccttg tgggcaagtt 4440
caagggctcc ttcctcattt accctgaatc agaggcagtg ttgttctctg agccccagat 4500
ctcccggggg atcccacaga accggcccat caagctcctg gtcagagtgt atgttgtaaa 4560
ggctaccaac ctggctcctg cagaccccaa tggcaaagca gacccttacg tggtggtgag 4620
cgctggccgg gagcggcagg acaccaagga acgctacatc cccaagcagc tcaaccccat 4680
ctttggagag atcctggagc taagcatctc tctcccagct gagacggagc tgacggtcgc 4740
cgtatttgat catgacctcg tgggttctga cgacctcatc ggggagaccc acattgatct 4800
ggaaaaccga ttctatagcc accacagagc aaactgtggg ctggcctccc agtatgaagt 4860
agatggttac aatgcctggc gtgatgcatt ctggccttcg cagatcctgg cggggctgtg 4920
ccaacgctgt ggcctccctg cccctgaata ccgagccggt gctgtcaagg tgggcagcaa 4980
agtcttcctg acaccaccgg agaccctgcc cccaggcagc agcagcccca cagtggcgag 5040
cggggaccct gaagaggccc aggcattgct tgtgctgcgg cgctggcagg aaatgccggg 5100
ttttgggatc cagctggtac ccgagcatgt agaaaccagg cctctctacc atccccacag 5160
cccagggctg ctacagggat ctcttcacat gtggattgac atctttcctc aagatgtgcc 5220
tgctccaccc ccagttgaca tcaagcctcg gcagccaatc agctatgagc tcagagttgt 5280
catctggaac acggaggatg tggttctgga tgacgagaat ccactcaccg gagagatgtc 5340
gagtgacatc tatgtgaaga gctgggtgaa ggggttggag catgacaagc aggagacaga 5400
cgttcacttc aactccctga ctggggaggg gaacttcaat tggcgctttg tgttccgctt 5460
tgactacctg cccacggagc gggaggtgag cgtctggcgc aggtctggac cctttgccct 5520
ggaggaggcg gagttccggc agcctgcagt gctggtcctg caggtctggg actatgaccg 5580
catctctgcc aatgacttcc ttggatccct ggagttgcag ctaccagaca tggtgcgtgg 5640
ggcccggggc cccgagctct gctctgtgca gctggcccgc aatggggccg ggccgaggtg 5700
caatctgttt cgctgccgcc gcctgagggg ctggtggccg gtagtgaagc tgaaggaggc 5760
agaggacgtg gagcgggagg cgcaggaggc tcaggctggc aagaagaagc gaaagcagag 5820
gaggaggaag ggccggccag aagacctgga gttcacagac atgggtggca atgtgtacat 5880
cctcacgggc aaggtggagg cagagtttga gctgctgact gtggaggagg ccgagaaacg 5940
gccagtgggg aaggggcgga agcagccaga gcctctggag aaacccagcc gccccaaaac 6000
ttccttcaac tggtttgtga acccgctgaa gacctttgtc ttcttcatct ggcgccggta 6060
ctggcgcacc ctggtgctgc tgctactggt gctgctcacc gtcttcctcc tcctggtctt 6120
ctacaccatc cctggccaga tcagccaggt catcttccgt cccctccaca agtgactctc 6180
gctgaccttg gacactcacc cagggtgcca acccttcaat gcctgctcct ggaagtcttt 6240
cttacccatg tgagctaccc cagagtctag tgcttcctct gaataaacct atcacagcc  6299



<210> 357
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 357
vcagggatct cttcacatgt ggattgacat ctttcctcaa gatgtgcctg ctccaccccc 60
avgttgacat caagcctcgg cagccaatca gctatgagct cagagttgtc atctggaaca 120
cgvgaggatg tggttctgga tgacgagaat ccactcaccg gagagatgtc gagtgacatc 180
tatvgtgaag agctgggtga aggggttgga gcatgacaag caggagacag acgttcactt 240
caacvtccct gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc 300
tgcccvacgg agcgggaggt gagcgtctgg cgcaggtctg gaccctttgc cctggaggag 360
gcggagvttc cggcagcctg cagtgctggt cctgcaggtc tgggactatg accgcatctc 420
tgccaatvga cttccttgga tccctggagt tgcagctacc agacatggtg cgtggggccc 480
ggggccccvg agctctgctc tgtgcagctg gcccgcaatg gggccgggcc gaggtgcaat 540
ctgtttcgcv tgccgccgcc tgaggggctg gtggccggta gtgaagctga aggaggcaga 600
ggacgtggag vcgggaggcg caggaggctc aggctggcaa gaagaagcga aagcagagga 660
ggaggaaggg cvcggccaga agacctggag ttcacagaca tgggtggcaa tgtgtacatc 720
ctcacgggca agvgtggagg cagagtttga gctgctgact gtggaggagg ccgagaaacg 780
gccagtgggg aagvgggcgg aagcagccag agcctctgga gaaacccagc cgccccaaaa 840
cttccttcaa ctggvtttgt gaacccgctg aagacctttg tcttcttcat ctggcgccgg 900
tactggcgca ccctgvgtgc tgctgctact ggtgctgctc accgtcttcc tcctcctggt 960
cttctacacc atccctvggc cagatcagcc aggtcatctt ccgtcccctc cacaagtgac 1020
tctcgctgac cttggacvac tcacccaggg tgccaaccct tcaatgcctg ctcctggaag 1080
tctttcttac ccatgtgavg ctaccccaga gtctagtgct tcctctgaat aaacctatca 1140
cagccvagat ggttacaatg cctggcgtga tgcattctgg ccttcgcaga tcctggcggg 1200
gctgtgvcca acgctgtggc ctccctgccc ctgaataccg agccggtgct gtcaaggtgg 1260
gcagcaavag tcttcctgac accaccggag accctgcccc cagg                  1304

<210> 358
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 358
vcagggatct cttcacatgt ggattgacat ctttcctcaa gatgtgcctg ctccaccccc 60
avgttgacat caagcctcgg cagccaatca gctatgagct cagagttgtc atctggaaca 120
cgvgaggatg tggttctgga tgacgagaat ccactcaccg gagagatgtc gagtgacatc 180
tatvgtgaag agctgggtga aggggttgga gcatgacaag caggagacag acgttcactt 240
caacvtccct gactggggag gggaacttca attggcgctt tgtgttccgc tttgactacc 300
tgcccvacgg agcgggaggt gagcgtctgg cgcaggtctg gaccctttgc cctggaggag 360
gcggagvttc cggcagcctg cagtgctggt cctgcaggtc tgggactatg accgcatctc 420
tgccaatvga cttccttgga tccctggagt tgcagctacc agacatggtg cgtggggccc 480
ggggccccvg agctctgctc tgtgcagctg gcccgcaatg gggccgggcc gaggtgcaat 540
ctgtttcgcv tgccgccgcc tgaggggctg gtggccggta gtgaagctga aggaggcaga 600
ggacgtggag vcgggaggcg caggaggctc aggctggcaa gaagaagcga aagcagagga 660
ggaggaaggg cvcggccaga agacctggag ttcacagaca tgggtggcaa tgtgtacatc 720
ctcacgggca agvgtggagg cagagtttga gctgctgact gtggaggagg ccgagaaacg 780
gccagtgggg aagvgggcgg aagcagccag agcctctgga gaaacccagc cgccccaaaa 840
cttccttcaa ctggvtttgt gaacccgctg aagacctttg tcttcttcat ctggcgccgg 900
tactggcgca ccctgvgtgc tgctgctact ggtgctgctc accgtcttcc tcctcctggt 960
cttctacacc atccctvggc cagatcagcc aggtcatctt ccgtcccctc cacaagtgac 1020
tctcgctgac cttggacvac tcacccaggg tgccaaccct tcaatgcctg ctcctggaag 1080
tctttcttac ccatgtgavg ctaccccaga gtctagtgct tcctctgaat aaacctatca 1140
cagccvagat ggttacaatg cctggcgtga tgcattctgg ccttcgcaga tcctggcggg 1200
gctgtgvcca acgctgtggc ctccctgccc ctgaataccg agccggtgct gtcaaggtgg 1260
gcagcaavag tcttcctgac accaccggag accctgcccc cagg                  1304

<210> 359
<211> 2036
<212> PRT
<213> Homo sapiens

<400> 359
Met Ala Leu Thr Val Ser Val Gln Arg Leu Thr Gly Leu Thr Gly Thr
 1               5                  10                  15      
His Asp Arg Gln Val Lys Leu Thr Phe Arg Gly Phe Thr Gln Lys Thr
            20                  25                  30          
Arg Lys Ile His Cys Gly Pro Glu Ala Asp Ile Gly Glu Leu Phe Arg
        35                  40                  45              
Trp Pro His Tyr Gly Ala Pro Leu Ala Gly Glu Cys Leu Ser Val Gln
    50                  55                  60                  
Val Val Asn Cys Ser Arg Val Phe Ser Leu Arg Pro Leu Gly Thr Leu
65                  70                  75                  80  
Val Ile Ser Leu Gln Gln Leu Gln Asn Ala Gly His Leu Val Leu Arg
                85                  90                  95      
Glu Ala Leu Val Asp Glu Asn Leu Gln Val Ser Pro Ile Gln Val Glu
            100                 105                 110         
Leu Asp Leu Lys Tyr Gln Pro Pro Glu Gly Ala Thr Gly Ala Trp Ser
        115                 120                 125             
Glu Glu Asp Phe Gly Ala Pro Ile Gln Asp Ser Phe Glu Leu Ile Ile
    130                 135                 140                 
Pro Asn Val Gly Phe Gln Glu Leu Glu Pro Gly Glu Ala Gln Leu Glu
145                 150                 155                 160 
Arg Arg Ala Val Ala Leu Gly Arg Arg Leu Ala Arg Ser Leu Gly Gln
                165                 170                 175     
Gln Asp Asp Glu Glu Asn Glu Leu Glu Leu Glu Leu Glu Gln Asp Leu
            180                 185                 190         
Asp Asp Glu Pro Asp Val Glu Leu Ser Gly Val Met Phe Ser Pro Leu
        195                 200                 205             
Lys Ser Arg Ala Arg Ala Leu Ala His Gly Asp Pro Phe Gln Val Ser
    210                 215                 220                 
Arg Ala Gln Asp Phe Gln Val Gly Val Thr Val Leu Glu Ala Gln Lys
225                 230                 235                 240 
Leu Val Gly Val Asn Ile Asn Pro Tyr Val Ala Val Gln Val Gly Gly
                245                 250                 255     
Gln Arg Arg Val Thr Ala Thr Gln Arg Gly Thr Ser Cys Pro Phe Tyr
            260                 265                 270         
Asn Glu Tyr Phe Leu Phe Glu Phe His Asp Thr Arg Leu Arg Leu Gln
        275                 280                 285             
Asp Leu Leu Leu Glu Ile Thr Val Ser Gly Val Gly Val Thr Ser Val
    290                 295                 300                 
Leu Gln Arg Arg Gly Asp Glu Lys Ala Ala Gly Leu Thr Pro Pro Ser
305                 310                 315                 320 
Pro Lys Ala Phe His Ser Gln Thr Leu Pro Phe Met Ala Thr Arg Ile
                325                 330                 335     
Gly Thr Phe Arg Met Asp Leu Gly Ile Ile Leu Asp Gln Pro Asp Gly
            340                 345                 350         
Gln Phe Tyr Gln Arg Trp Val Pro Leu His Asp Pro Arg Asp Thr Arg
        355                 360                 365             
Ala Gly Thr Lys Gly Phe Ile Lys Val Thr Leu Ser Val Arg Ala Arg
    370                 375                 380                 
Gly Asp Leu Pro Pro Pro Met Leu Pro Pro Ala Pro Gly His Cys Ser
385                 390                 395                 400 
Asp Ile Glu Lys Asn Leu Leu Leu Pro Arg Gly Val Pro Ala Glu Arg
                405                 410                 415     
Pro Trp Ala Arg Leu Arg Val Arg Leu Tyr Arg Ala Glu Gly Leu Pro
            420                 425                 430         
Ala Leu Arg Leu Gly Leu Leu Gly Ser Leu Val Arg Ala Leu His Asp
        435                 440                 445             
Gln Arg Val Leu Val Glu Pro Tyr Val Arg Val Ser Phe Leu Gly Gln
    450                 455                 460                 
Glu Gly Glu Thr Ser Val Ser Ala Glu Ala Ala Ala Pro Glu Trp Asn
465                 470                 475                 480 
Glu Gln Leu Ser Phe Val Glu Leu Phe Pro Pro Leu Thr Arg Ser Leu
                485                 490                 495     
Arg Leu Gln Leu Arg Asp Asp Ala Pro Leu Val Asp Ala Ala Leu Ala
            500                 505                 510         
Thr His Val Pro Asp Leu Arg Arg Ile Ser His Pro Gly Arg Ala Ala
        515                 520                 525             
Gly Phe Asn Pro Thr Phe Gly Pro Ala Trp Val Pro Leu Tyr Gly Ser
    530                 535                 540                 
Pro Pro Gly Ala Gly Leu Arg Asp Ser Leu Gln Gly Leu Asn Glu Gly
545                 550                 555                 560 
Val Gly Gln Gly Ile Trp Phe Arg Gly Arg Leu Leu Leu Ala Val Ser
                565                 570                 575     
Met Gln Val Leu Glu Gly Arg Ala Glu Pro Glu Pro Pro Gln Ala Gln
            580                 585                 590         
Gln Gly Ser Thr Leu Ser Arg Leu Thr Arg Lys Lys Lys Lys Lys Ala
        595                 600                 605             
Arg Arg Asp Gln Thr Pro Lys Ala Val Pro Gln His Leu Asp Ala Ser
    610                 615                 620                 
Pro Gly Ala Glu Gly Pro Glu Ile Pro Arg Ala Met Glu Val Glu Val
625                 630                 635                 640 
Glu Glu Leu Leu Pro Leu Pro Glu Asn Val Leu Ala Pro Cys Glu Asp
                645                 650                 655     
Phe Leu Leu Phe Gly Val Leu Phe Glu Ala Thr Met Ile Asp Pro Thr
            660                 665                 670         
Val Ala Ser Gln Pro Ile Ser Phe Glu Ile Ser Ile Gly Arg Ala Gly
        675                 680                 685             
Arg Leu Glu Glu Gln Leu Gly Arg Gly Ser Arg Ala Gly Glu Gly Thr
    690                 695                 700                 
Glu Gly Ala Ala Val Glu Ala Gln Pro Leu Leu Gly Ala Arg Pro Glu
705                 710                 715                 720 
Glu Glu Lys Glu Glu Glu Glu Leu Gly Thr His Ala Gln Arg Pro Glu
                725                 730                 735     
Pro Met Asp Gly Ser Gly Pro Tyr Phe Cys Leu Pro Leu Cys His Cys
            740                 745                 750         
Lys Pro Cys Met His Val Trp Ser Cys Trp Glu Asp His Thr Trp Arg
        755                 760                 765             
Leu Gln Ser Ser Asn Cys Val Arg Lys Val Ala Glu Arg Leu Asp Gln
    770                 775                 780                 
Gly Leu Gln Glu Val Glu Arg Leu Gln Arg Lys Pro Gly Pro Gly Ala
785                 790                 795                 800 
Cys Ala Gln Leu Lys Gln Ala Leu Glu Val Leu Val Ala Gly Ser Arg
                805                 810                 815     
Gln Phe Cys His Gly Ala Glu Arg Arg Thr Met Thr Arg Pro Asn Ala
            820                 825                 830         
Leu Asp Arg Cys Arg Gly Lys Leu Leu Val His Ser Leu Asn Leu Leu
        835                 840                 845             
Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly Leu Arg Arg Arg Asn Val
    850                 855                 860                 
Gln Lys Lys Val Ala Leu Ala Lys Lys Leu Leu Ala Lys Leu Arg Phe
865                 870                 875                 880 
Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro Asp Val Leu Val Trp Met
                885                 890                 895     
Leu Ser Gly Gln Arg Arg Val Ala Trp Ala Arg Ile Pro Ala Gln Asp
            900                 905                 910         
Val Leu Phe Ser Val Val Glu Glu Glu Arg Gly Arg Asp Cys Gly Lys
        915                 920                 925             
Ile Gln Ser Leu Met Leu Thr Ala Pro Gly Ala Ala Pro Gly Glu Val
    930                 935                 940                 
Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu Gly Leu Gly Lys Gln Ala
945                 950                 955                 960 
Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp Leu Leu Pro Glu Pro Ser
                965                 970                 975     
Ala Gly Leu Pro Ser Ser Leu His Arg Asp Asp Phe Ser Tyr Phe Gln
            980                 985                 990         
Leu Arg Ala His Leu Tyr Gln Ala Arg Gly Val Leu Ala Ala Asp Asp
        995                 1000                1005            
Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Leu Ile Ser Thr Gln Cys
    1010                1015                1020                
Gln Thr Thr Arg Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu
1025                1030                1035                1040
Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu
                1045                1050                1055    
Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys
            1060                1065                1070        
Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val
        1075                1080                1085            
Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro
    1090                1095                1100                
Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln
1105                1110                1115                1120
Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu Pro Ser Val Pro Ser
                1125                1130                1135    
Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val Glu Pro His Ser Gly
            1140                1145                1150        
Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val Leu Arg Glu Phe Arg
        1155                1160                1165            
Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu Gly Arg Val His Leu
    1170                1175                1180                
Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu Val Ala Gly Gln Gly
1185                1190                1195                1200
Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu Ser Pro Asn Phe Thr
                1205                1210                1215    
Glu Leu Val Arg His Leu Thr Val Val Phe Lys Asp Thr Ala Pro Leu
            1220                1225                1230        
Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr Leu Gln Pro Pro Leu
        1235                1240                1245            
Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly His Thr Val Leu Val
    1250                1255                1260                
Gly Ser His Ile Val Pro His Met Leu Arg Phe Thr Phe Arg Gly His
1265                1270                1275                1280
Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu Glu Thr Gly Asp Met
                1285                1290                1295    
Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu Asp Pro Phe Leu Ala
            1300                1305                1310        
Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys Pro Pro Leu Lys Lys Leu
        1315                1320                1325            
Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro Gly Leu Glu Glu Asp Ile
    1330                1335                1340                
Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser Lys Tyr Tyr Ala Ser Leu
1345                1350                1355                1360
Gln Glu Leu Gln Gly Gln His Asn Phe Asp Glu Asp Glu Met Asp Asp
                1365                1370                1375    
Pro Gly Asp Ser Asp Gly Val Asn Leu Ile Ser Met Val Gly Glu Ile
            1380                1385                1390        
Gln Asp Gln Gly Glu Ala Glu Val Lys Gly Thr Val Ser Pro Lys Lys
        1395                1400                1405            
Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg Ser Leu Lys Glu Glu Phe
    1410                1415                1420                
Asn His Phe Glu Asp Trp Leu Asn Val Phe Pro Leu Tyr Arg Gly Gln
1425                1430                1435                1440
Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu Gly Ser Gly His Leu Val
                1445                1450                1455    
Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr Pro Glu Ser Glu Ala Val
            1460                1465                1470        
Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly Ile Pro Gln Asn Arg Pro
        1475                1480                1485            
Ile Lys Leu Leu Val Arg Val Tyr Val Val Lys Ala Thr Asn Leu Ala
    1490                1495                1500                
Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro Tyr Val Val Val Ser Ala
1505                1510                1515                1520
Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg Tyr Ile Pro Lys Gln Leu
                1525                1530                1535    
Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu Ser Ile Ser Leu Pro Ala
            1540                1545                1550        
Glu Thr Glu Leu Thr Val Ala Val Phe Asp His Asp Leu Val Gly Ser
        1555                1560                1565            
Asp Asp Leu Ile Gly Glu Thr His Ile Asp Leu Glu Asn Arg Phe Tyr
    1570                1575                1580                
Ser His His Arg Ala Asn Cys Gly Leu Ala Ser Gln Tyr Glu Val Asp
1585                1590                1595                1600
Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp Pro Ser Gln Ile Leu Ala
                1605                1610                1615    
Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala Pro Glu Tyr Arg Ala Gly
            1620                1625                1630        
Ala Val Lys Val Gly Ser Lys Val Phe Leu Thr Pro Pro Glu Thr Leu
        1635                1640                1645            
Pro Pro Gly Ser Ser Ser Pro Thr Val Ala Ser Gly Asp Pro Glu Glu
    1650                1655                1660                
Ala Gln Ala Leu Leu Val Leu Arg Arg Trp Gln Glu Met Pro Gly Phe
1665                1670                1675                1680
Gly Ile Gln Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Tyr His
                1685                1690                1695    
Pro His Ser Pro Gly Leu Leu Gln Gly Ser Leu His Met Trp Ile Asp
            1700                1705                1710        
Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro Val Asp Ile Lys Pro
        1715                1720                1725            
Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val Ile Trp Asn Thr Glu
    1730                1735                1740                
Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr Gly Glu Met Ser Ser
1745                1750                1755                1760
Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu Glu His Asp Lys Gln
                1765                1770                1775    
Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly Glu Gly Asn Phe Asn
            1780                1785                1790        
Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro Thr Glu Arg Glu Val
        1795                1800                1805            
Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu Glu Glu Ala Glu Phe
    1810                1815                1820                
Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp Asp Tyr Asp Arg Ile
1825                1830                1835                1840
Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu Gln Leu Pro Asp Met
                1845                1850                1855    
Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser Val Gln Leu Ala Arg
            1860                1865                1870        
Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg Cys Arg Arg Leu Arg
        1875                1880                1885            
Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala Glu Asp Val Glu Arg
    1890                1895                1900                
Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys Arg Lys Gln Arg Arg
1905                1910                1915                1920
Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr Asp Met Gly Gly Asn
                1925                1930                1935    
Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu Phe Glu Leu Leu Thr
            1940                1945                1950        
Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys Gly Arg Lys Gln Pro
        1955                1960                1965            
Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr Ser Phe Asn Trp Phe
    1970                1975                1980                
Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile Trp Arg Arg Tyr Trp
1985                1990                1995                2000
Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu Thr Val Phe Leu Leu
                2005                2010                2015    
Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser Gln Val Ile Phe Arg
            2020                2025                2030        
Pro Leu His Lys
        2035    


<210> 360
<211> 334
<212> PRT
<213> Homo sapiens

<400> 360
Val Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro
 1               5                  10                  15      
Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val
            20                  25                  30          
Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr
        35                  40                  45              
Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Val Lys Gly
    50                  55                  60                  
Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
65                  70                  75                  80  
Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
                85                  90                  95      
Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
            100                 105                 110         
Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Val Leu Val Leu Gln
        115                 120                 125             
Val Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu
    130                 135                 140                 
Glu Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu
145                 150                 155                 160 
Cys Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu
                165                 170                 175     
Phe Arg Cys Arg Arg Leu Arg Val Gly Trp Trp Pro Val Val Lys Leu
            180                 185                 190         
Lys Glu Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly
        195                 200                 205             
Lys Lys Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu
    210                 215                 220                 
Glu Phe Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val
225                 230                 235                 240 
Glu Ala Glu Phe Val Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg
                245                 250                 255     
Pro Val Gly Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser
            260                 265                 270         
Arg Pro Lys Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe
        275                 280                 285             
Val Phe Phe Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu
    290                 295                 300                 
Leu Val Val Leu Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile
305                 310                 315                 320 
Pro Gly Gln Ile Ser Gln Val Ile Phe Arg Pro Leu His Lys
                325                 330                 


<210> 361
<211> 329
<212> PRT
<213> Homo sapiens

<400> 361
Val Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro Pro
 1               5                  10                  15      
Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val Val
            20                  25                  30          
Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu Thr
        35                  40                  45              
Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly Leu
    50                  55                  60                  
Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr Gly
65                  70                  75                  80  
Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu Pro
                85                  90                  95      
Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala Leu
            100                 105                 110         
Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val Trp
        115                 120                 125             
Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu Leu
    130                 135                 140                 
Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys Ser
145                 150                 155                 160 
Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe Arg
                165                 170                 175     
Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu Ala
            180                 185                 190         
Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys Lys
        195                 200                 205             
Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe Thr
    210                 215                 220                 
Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala Glu
225                 230                 235                 240 
Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly Lys
                245                 250                 255     
Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys Thr
            260                 265                 270         
Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe Ile
        275                 280                 285             
Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu Leu
    290                 295                 300                 
Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile Ser
305                 310                 315                 320 
Gln Val Ile Phe Arg Pro Leu His Lys
                325                 


<210> 362
<211> 6855
<212> DNA
<213> Homo sapiens

<400> 362
agaagaaagc tggtaggggc tgggagaggg taccacaggg gagtatgatc tacttggggg 60
ccagagaagg ttccctgagg aaatagtacc tgaacttaga cttgaaggat aacagatgtt 120
aactgggagg agagaatgtt ccaggcagag gaaaaggcat atgcaaaagt ccagcgcctt 180
gaaggagcac agctggggtg cctggagtga gatggagctg gaaagatcca ggtggagctt 240
gacctgaagt accagccccc agagggcgct actggagcct ggtcagagga ggactttggg 300
gcacccatcc aggacagctt cgagttaatc atccccaatg tgggcttcca ggaactggag 360
cctggggagg cccagctgga gcggcgggca gtggctctag gccgcaggct agctcgaagt 420
ctaggccagc aggacgatga agagaatgag ctggagcttg agctggagca ggacctggat 480
gatgagcctg acgtggaact ttctggtgtt atgttcagcc ccctcaagag ccgcgccagg 540
gccctggccc atggggatcc cttccaggtg tccagagctc aagacttcca ggtgggagtc 600
actgtgctgg aagcccagaa actggtggga gtcaacatta acccctatgt ggccgtgcaa 660
gtgggggggc agcgccgtgt gaccgccaca cagcgtggga ccagttgccc cttctacaat 720
gagtacttct tgttcgaatt tcatgacacg cggcttcgtc tccaagactt gctgctggag 780
atcacggtga gtggggtagg ggtgaccagt gtccttcaga gaagggggga tgagaaagct 840
gcaggactaa caccaccttc ccccaaggct ttccattcgc agaccctccc ctttatggcc 900
acccggatag gcaccttcag gatggacctg ggcatcatct tggaccagcc aggtatggaa 960
tcgtcccctt attgagactc tgcacggaca agggccctag agattgaccc tgcagtgact 1020
ccgcatggac ccctatacac tcacttcgga gagggccatc tctggcggag gctgaactct 1080
tggcacttcc gcccctccct gctgagccag agaagccctg gccattgtcc gtcactccga 1140
tagcctcacg gccaccctgt gcgtcccgcc ggtcgcccct tacccctggc tcgccccttc 1200
gcccttagat ggccagttct accaaagatg ggttccgctg catgatcccc gagacacccg 1260
cgccgggacc aagggtttca ttaaggtcac cttgtccgtg agggcgcgcg gggacctgcc 1320
ccctccaatg ctacccccgg ccccagggca ctgttcggac atcgagaagt gagccggggt 1380
gaggtgggga ggaggacatg gatccggggg tggccgtggg gcgcggataa ggggaggggc 1440
cgagatccca gtttctcccc ccccgctcgg tgccccctcc cctaggaacc tgctcctgcc 1500
gcgcggggtg cccgccgaga ggccatgggc gcggctccgc gtgcgcctgt accgcgccga 1560
ggggcttccc gcgctgcgcc tggggctgct gggcagcctg gtccgcgccc tgcacgacca 1620
gcgcgtcctg gtggagccct atgtgcgggt gtctttcctg gggcaggagg gcgagacgtc 1680
ggtgagcgcc gaggcggcgg cgcccgaatg gaacgagcag ctgagcttcg tggagctctt 1740
cccgccgctg acgcgcagcc tccgcctgca gctgcgggac gacgcgcccc tggtcgacgc 1800
ggcactcgct acgcacgtgc cggacctgag gcggatctcc catccgggcc gcgcggcggg 1860
gtttaaccct accttcggcc cggcctgggt gcccctctat ggctcgcccc ccggcgcggg 1920
gctccgggat agtcttcaag gtctcaacga aggcgttggc caaggcattt ggttccgcgg 1980
ccgccttctg ctggctgtgt ccatgcaggt gttggaaggg agagctgaac ctgagcctcc 2040
ccaggcccag caggggtcca cgttgtcccg gctcacccga aagaagaaaa agaaagccag 2100
aagggatcag accccaaagg cggttccgca gcacttggac gccagccccg gtgccgaggg 2160
gcctgagatc ccccgtgcca tggaggtgga ggtggaggag ctgctgccgc tgccagagaa 2220
tgtcctggcg ccctgtgaag atttcctgct tttcggtgtg ctcttcgagg ccaccatgat 2280
cgaccccacc gtggcctccc agcccatcag cttcgagatc tccattggtg tgtggcctag 2340
ccgaacccct gagtgccatt tcagacctta gaaccctgga aggggtgttg actttcagtc 2400
gcgcaggccg tctggaggag caattgggcc gagggtccag ggctggggag ggaactgagg 2460
gtgcagccgt ggaggctcag cctctgctgg gagccaggcc agaggaggag aaagaggagg 2520
aagaactggg gacccatgct cagcggcctg agcccatgga cggcagtggg ccatacttct 2580
gcttgcccct ctgtcactgc aagccatgca tgcatgtgtg gagttgctgg gaggaccaca 2640
cctggcgcct gcagagcagc aactgcgtgc gcaaagtggc cgagaggctg gaccaggggc 2700
tgcaggaggt tgagagactg cagcgcaagc cggggcctgg cgcctgtgca cagctcaagc 2760
aggcactgga agtactggtg gctgggagca gacagttttg ccacggtgcc gagcgcagga 2820
cgatgacccg gcccaatgcc ctggatcgat gccgagggaa actcctggtg cacagcctga 2880
accttttggc taagcaagga ctgcgacttc tacgcggcct gagacggcgc aatgtgcaaa 2940
agaaggtggc actggccaag aagctcctgg caaaactgcg ctttctggct gaggaggcac 3000
ccggggcagc ccctggtgag gtctgtgcca agctggagct cttcctgcgg ctgggcctgg 3060
gcaagcaagc caaggcctgc acctctgagc tgcccccgga tttgctgccc gagccctcag 3120
ccgggctgcc ctccagccta caccgggacg gtcctggagc agacgctgag ccctctgtgg 3180
gatgaactcc tggtatttga gcagttgatc gtggatggga ggagggagca cctgcaggag 3240
gagcctccat tagtgatcat caatgtattt gaccacaata agtttggccc ccccgtgttc 3300
ctgggcaggg cactggccgc cccaagggta aagctgatgg aggacccata ccaacgccca 3360
gagttgcagt tcttccccct gaggaaggga ccctgggcag ccggagagct cattgccgcc 3420
tttcaactca ttgaactaga ctacagtggc cgacttgagc cctcagtgcc cagtgaggtg 3480
gagccccagg atctggcacc cctggttgag ccccactctg gacgcctgtc ccttccaccc 3540
aacgtgtgcc cagtgctcag ggagttccgt gttgaggtgc tgttctgggg tcttagggga 3600
cttggtcgtg tgcatctgct cgaggtggag cagccccagg ttgtactgga ggtggctggg 3660
caaggtgtgg agtctgaggt cctggccagc taccgtgaga gccccaattt cactgagctt 3720
gtcaggcatc tgacagtggt cttcaaagac acagctcctc tcttccaccc ccaggacttg 3780
ccggagcagc cttacttgca gcctccactc agcatcttgg tgattgagcg ccgggccttt 3840
ggccacacag tccttgtggg ttcccacatt gtcccccaca tgctgcgatt cacatttcgg 3900
ggtcatgagg atcctcctga ggaggaagga gagatggagg agacagggga tatgatgccc 3960
aagggacctc aaggacagaa gtccctggat cccttcttgg ctgaagcggg tatatccaga 4020
cagctcctga agcacaactt tgatgaagat gaaatggatg atcctggaga ttcagatggg 4080
gtcaacctca tttctatggt tggggagatc caagaccagg gtgaggctga agtcaaaggc 4140
actgtgtccc caaaaaaagc agttgccacc ctgaagatct acaacaggtc cctgaaggaa 4200
gaatttaacc actttgaaga ctggctgaat gtgtttcctc tgtaccgagg gcaagggggc 4260
caggatggag gtggagaaga ggaaggatct ggacaccttg tgggcaagtt caagggctcc 4320
ttcctcattt accctgaatc agaggcagtg ttgttctctg agccccagat ctcccggggg 4380
atcccacaga accggcccat caagctcctg gtcagagtgt atgttgtaaa ggctaccaac 4440
ctggctcctg cagaccccaa tggcaaagca gacccttacg tggtggtgag cgctggccgg 4500
gagcggcagg acaccaagga acgctacatc cccaagcagc tcaaccccat ctttggagag 4560
atcctggagc taagcatctc tctcccagct gagacggagc tgacggtcgc cgtatttgat 4620
catgacctcg tgggttctga cgacctcatc ggggagaccc acattgatct ggaaaaccga 4680
ttctatagcc accacagagc aaactgtggg ctggcctccc agtatgaagt gtgggtccag 4740
cagggcccac aggagccatt ctgagtttct ggccaaacac attcaagctc acattccctt 4800
ttgtgtctcc agatcctatg atttcatgga aggggaccct cccacccacc gccactgcca 4860
accaagacat agctcagtgg tcaagacttg ggcttgggag tcgggatcct gtaacgaatg 4920
tcacttgacc gctttctttt tttatgaaac agtctcgctc tgtctcccag gttggagtgc 4980
agtggcacga tctcggctga ctgcaacctc cacctcctgg gttcaagcga ttctcctgcc 5040
tcagcctccc cagtagctgg gattacaggc gtgggccccc atgtccagct aatttttata 5100
ttttcgctct gtctcccagg ttggagtgca gtggcacgat ctcggctgac tgcaacctcc 5160
acctcctggg ttcaagcgat tctcctgcct cagcctcccc agtagctggg attacaggcg 5220
tgggccccca tgtccagcta atttttatat ttttagtaga gacagggttt caccatgttg 5280
tccaggctgg tcttgaaccc ctgacctcaa gtgatccacc cacctctgcc tcccaaagtg 5340
ctgggattac aggtgtgagc caccatgcca ggccctctta acctcttcaa gtctgttttc 5400
tcatctgcaa aacagaggta ataagatcag tatcttctta atggaagcac ctggactaca 5460
tttttttcat tcattgttat cataaatgag gactaacctg tctcccgttg ggagttttga 5520
acctagacct catgtcttca tgacgtcatc actgccccag gcccagctgt gtccctacac 5580
cagccccagc tgacgcatct tctttttctg cctgtagaga tggttacaat gcctggcgtg 5640
atgcattctg gccttcgcag atcctggcgg ggctgtgcca acgctgtggc ctccctgccc 5700
ctgaataccg agccggtgct gtcaaggtgg gcagcaaagt cttcctgaca ccaccggaga 5760
ccctgccccc agggatctct tcacatgtgg attgacatct ttcctcaaga tgtgcctgct 5820
ccacccccag ttgacatcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 5880
tggaacacgg aggatgtggt tctggatgac gagaatccac tcaccggaga gatgtcgagt 5940
gacatctatg tgaagagctg ggtgaagggg ttggagcatg acaagcagga gacagacgtt 6000
cacttcaact ccctgactgg ggaggggaac ttcaattggc gctttgtgtt ccgctttgac 6060
tacctgccca cggagcggga ggtgagcgtc tggcgcaggt ctggaccctt tgccctggag 6120
gaggcggagt tccggcagcc tgcagtgctg gtcctgcagg atccctggag ttgcagctac 6180
cagacatggt gcgtggggcc cggggccccg agctctgctc tgtgcagctg gcccgcaatg 6240
gggccgggcc gaggtgcaat ctgtttcgct gccgccgcct gaggggctgg tggccggtag 6300
tgaagctgaa ggaggcagag gacgtggagc gggaggcgca ggaggctcag gctggcaaga 6360
agaagcgaaa gcagaggagg aggaagggcc ggccagaaga cctggagttc acagacatgg 6420
gtggcaatgt gtacatcctc acgggcaagg tggaggcaga gtttgagctg ctgactgtgg 6480
aggaggccga gaaacggcca gtggggaagg ggcggaagca gccagagcct ctggagaaac 6540
ccagccgccc caaaacttcc ttcaactggt ttgtgaaccc gctgaagacc tttgtcttct 6600
tcatctggcg ccggtactgg cgcaccctgg tgctgctgct actggtgctg ctcaccgtct 6660
tcctcctcct ggtcttctac accatccctg gccagatcag ccaggtcatc ttccgtcccc 6720
tccacaagtg actctcgctg accttggaca ctcacccagg gtgccaaccc ttcaatgcct 6780
gctcctggaa gtctttctta cccatgtgag ctaccccaga gtctagtgct tcctctgaat 6840
aaacctatca cagcc                                                  6855



<210> 363
<211> 1954
<212> DNA
<213> Homo sapiens

<400> 363
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgc tgggtgaagg ggttggagca tgacaagcag gagacagacg 1080
ttcacttcaa ctccctgavc tggggagggg aacttcaatt ggcgctttgt gttccgcttt 1140
gactacctgc ccacggagcv gggaggtgag cgtctggcgc aggtctggac cctttgccct 1200
ggaggaggcg gagttccggc vagcctgcag tgctggtcct gcaggvggat ccctggagtt 1260
gcagctacca gacatggtgc gtggggcccg gggccccgag ctctgcvtct gtgcagctgg 1320
cccgcaatgg ggccgggccg aggtgcaatc tgtttcgctg ccgccgcvct gaggggctgg 1380
tggccggtag tgaagctgaa ggaggcagag gacgtggagc gggaggcgvc aggaggctca 1440
ggctggcaag aagaagcgaa agcagaggag gaggaagggc cggccagaav gacctggagt 1500
tcacagacat gggtggcaat gtgtacatcc tcacgggcaa ggtggaggca vgagtttgag 1560
ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa gvcagccaga 1620
gcctctggag aaacccagcc gccccaaaac ttccttcaac tggtttgtga acvccgctga 1680
agacctttgt cttcttcatc tggcgccggt actggcgcac cctggtgctg ctgvctactg 1740
gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca gatcvagcca 1800
ggtcatcttc cgtcccctcc acaagtgact ctcgctgacc ttggacactc acccavgggt 1860
gccaaccctt caatgcctgc tcctggaagt ctttcttacc catgtgagct accccavgag 1920
tctagtgctt cctctgaata aacctatcac agcc                             1954

<210> 364
<211> 1954
<212> DNA
<213> Homo sapiens

<400> 364
vtttttttat gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg 60
gvctgactgc aacctccacc tcctgggttc aagcgattct cctgcctcag cctccccagt 120
agvctgggat tacaggcgtg ggcccccatg tccagctaat ttttatattt tcgctctgtc 180
tccvcaggtt ggagtgcagt ggcacgatct cggctgactg caacctccac ctcctgggtt 240
caagvcgatt ctcctgcctc agcctcccca gtagctggga ttacaggcgt gggcccccat 300
gtccavgcta atttttatat ttttagtaga gacagggttt caccatgttg tccaggctgg 360
tcttgavacc cctgacctca agtgatccac ccacctctgc ctcccaaagt gctgggatta 420
caggtgtvga gccaccatgc caggccctct taacctcttc aagtctgttt tctcatctgc 480
aaaacagavg gtaataagat cagtatcttc ttaatggaag cacctggact acattttttt 540
cattcattgv ttatcataaa tgaggactaa cctgtctccc gttgggagtt ttgaacctag 600
acctcatgtc vttcatgacg tcatcactgc cccaggccca gctgtgtccc tacaccagcc 660
ccagctgacg cvatcttctt tttctgcctg tagagatggt tacaatgcct ggcgtgatgc 720
attctggcct tcvgcagatc ctggcggggc tgtgccaacg ctgtggcctc cctgcccctg 780
aataccgagc cggvtgctgt caaggtgggc agcaaagtct tcctgacacc accggagacc 840
ctgcccccag ggatvctctt cacatgtgga ttgacatctt tcctcaagat gtgcctgctc 900
cacccccagt tgacavtcaa gcctcggcag ccaatcagct atgagctcag agttgtcatc 960
tggaacacgg aggatgvtgg ttctggatga cgagaatcca ctcaccggag agatgtcgag 1020
tgacatctat gtgaagavgc tgggtgaagg ggttggagca tgacaagcag gagacagacg 1080
ttcacttcaa ctccctgavc tggggagggg aacttcaatt ggcgctttgt gttccgcttt 1140
gactacctgc ccacggagcv gggaggtgag cgtctggcgc aggtctggac cctttgccct 1200
ggaggaggcg gagttccggc vagcctgcag tgctggtcct gcaggvggat ccctggagtt 1260
gcagctacca gacatggtgc gtggggcccg gggccccgag ctctgcvtct gtgcagctgg 1320
cccgcaatgg ggccgggccg aggtgcaatc tgtttcgctg ccgccgcvct gaggggctgg 1380
tggccggtag tgaagctgaa ggaggcagag gacgtggagc gggaggcgvc aggaggctca 1440
ggctggcaag aagaagcgaa agcagaggag gaggaagggc cggccagaav gacctggagt 1500
tcacagacat gggtggcaat gtgtacatcc tcacgggcaa ggtggaggca vgagtttgag 1560
ctgctgactg tggaggaggc cgagaaacgg ccagtgggga aggggcggaa gvcagccaga 1620
gcctctggag aaacccagcc gccccaaaac ttccttcaac tggtttgtga acvccgctga 1680
agacctttgt cttcttcatc tggcgccggt actggcgcac cctggtgctg ctgvctactg 1740
gtgctgctca ccgtcttcct cctcctggtc ttctacacca tccctggcca gatcvagcca 1800
ggtcatcttc cgtcccctcc acaagtgact ctcgctgacc ttggacactc acccavgggt 1860
gccaaccctt caatgcctgc tcctggaagt ctttcttacc catgtgagct accccavgag 1920
tctagtgctt cctctgaata aacctatcac agcc                             1954

<210> 365
<211> 610
<212> PRT
<213> Homo sapiens

<400> 365
Met Cys Lys Arg Arg Trp His Trp Pro Arg Ser Ser Trp Gln Asn Cys
 1               5                  10                  15      
Ala Phe Trp Leu Arg Arg His Pro Gly Gln Pro Leu Val Arg Ser Val
            20                  25                  30          
Pro Ser Trp Ser Ser Ser Cys Gly Trp Ala Trp Ala Ser Lys Pro Arg
        35                  40                  45              
Pro Ala Pro Leu Ser Cys Pro Arg Ile Cys Cys Pro Ser Pro Gln Pro
    50                  55                  60                  
Gly Cys Pro Pro Ala Tyr Thr Gly Thr Val Leu Glu Gln Thr Leu Ser
65                  70                  75                  80  
Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp Gly
                85                  90                  95      
Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn Val
            100                 105                 110         
Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala Leu
        115                 120                 125             
Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro Glu
    130                 135                 140                 
Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu Leu
145                 150                 155                 160 
Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu Glu
                165                 170                 175     
Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu Val
            180                 185                 190         
Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro Val
        195                 200                 205             
Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly Leu
    210                 215                 220                 
Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu Glu
225                 230                 235                 240 
Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg Glu
                245                 250                 255     
Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe Lys
            260                 265                 270         
Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro Tyr
        275                 280                 285             
Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe Gly
    290                 295                 300                 
His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg Phe
305                 310                 315                 320 
Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met Glu
                325                 330                 335     
Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser Leu
            340                 345                 350         
Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys His
        355                 360                 365             
Asn Phe Asp Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val
    370                 375                 380                 
Asn Leu Ile Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu
385                 390                 395                 400 
Val Lys Gly Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile
                405                 410                 415     
Tyr Asn Arg Ser Leu Lys Glu Glu Phe Asn His Phe Glu Asp Trp Leu
            420                 425                 430         
Asn Val Phe Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly
        435                 440                 445             
Glu Glu Glu Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe
    450                 455                 460                 
Leu Ile Tyr Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile
465                 470                 475                 480 
Ser Arg Gly Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val
                485                 490                 495     
Tyr Val Val Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys
            500                 505                 510         
Ala Asp Pro Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr
        515                 520                 525             
Lys Glu Arg Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile
    530                 535                 540                 
Leu Glu Leu Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala
545                 550                 555                 560 
Val Phe Asp His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr
                565                 570                 575     
His Ile Asp Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys
            580                 585                 590         
Gly Leu Ala Ser Gln Tyr Glu Val Trp Val Gln Gln Gly Pro Gln Glu
        595                 600                 605             
Pro Phe
    610 

